Intra-Workout Supplementation: The Secret To New Gains!

The goal of any hardcore bodybuilder and even the weekend warrior is to build a lean, dense, muscular physique. Here's more on the importance of intra-workout supplementation for building mass. Learn more!

Article Summary:
  • Resistance training causes a release of a catabolic hormone.
  • As you workout you lose glycogen, electrolytes and amino acids.
  • Intra-workout supplementation can lessen catabolic hormone levels.

  • The Secret To New Gains!

    The latest clinical research on intra-workout supplementation might change the way you train and build muscle - forever!

    The goal of any hardcore bodybuilder and even the weekend warrior is to build a lean, dense, muscular physique. There's no doubt that if you've ever touched a dumbbell, you've heard of pre- and post-workout nutrition. But have you ever heard of intra-workout supplementation?

    If You've Ever Touched A Dumbbell, You've Heard Of Pre- And Post-Workout Nutrition.
    + Click To Enlarge.
    If You've Ever Touched A Dumbbell, You've
    Heard Of Pre- And Post-Workout Nutrition.

    Well, if you haven't, you'll definitely be hearing a whole lot about it now - especially with all the groundbreaking clinical studies supporting the muscle-building potential of intra-workout supplementation. In fact, new research has revealed that intra-workout supplementation is critical to activating peak in-gym performance as well as generating the optimum anabolic environment conducive to new gains in size and strength.

    Resistance Training Releases Muscle-Limiting Catabolic Signals

      What many bodybuilders don't realize is that a number of catabolic factors are activated during training - many of which interfere with optimal strength production and muscular development. For starters, resistance exercise stimulates heightened changes in the rate of muscle protein turnover, resulting in an increase in both protein synthesis and degradation. 1

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      Another clinical study took it a step further by identifying that net muscle protein balance was negative in the early stages of recovery. 2 The aforementioned findings reiterate the importance of minimizing muscle breakdown. This can be done by controlling supplementation and nutrient timing to maximize anabolism.

      Failure to properly support exercise-induced recovery with the appropriate nutrient profile actually leads to muscle degeneration. Even more alarming, another clinical study discovered that resistance exercise designed to maximally stimulate the major muscle groups being trained produced hypersecretion of [a highly catabolic hormone].3 The more catabolic hormone present in your system, the higher the likelihood of increased muscle degradation and diminished strength.

    Resistance Exercise Designed To Stimulate The Major Muscle Groups Produced Hypersecretion Of A Highly Catabolic Hormone.
    + Click To Enlarge.
    Resistance Exercise Designed To Stimulate The Major Muscle
    Groups Produced Hypersecretion Of A Highly Catabolic Hormone.

      The underlying message is if you want to pack on pounds of lean muscle, you need to mitigate your body's natural response to increase muscle protein degradation following intense bouts of resistance training. This involves controlling insulin concentration levels through proper nutrition.

    Peak Performance Heavily Dependent On Muscle Energy Reserves

      Another major limiting factor that may negatively affect your performance in the gym is the declining presence of glycogen, electrolytes, as well as essential and non-essential amino acids in your system during intense bouts of training. All three elements work in synchrony to generate peak muscle contractile energy during training as well as protein synthesis.


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      As you progress through set after set of muscle fiber-tearing weight, your muscle energy stores gradually deplete. Therefore, you need to find a method of replenishing these stores between sets for optimal muscle performance. Intra-workout supplementation is the perfect solution.

    Clinical Research Proves You Can Pack On 9 lbs. Of Lean Muscle

      There's no doubt that proper post-workout nutrition is essential to defeating catabolism, but the latest research on intra-workout supplementation will change the way you build muscle - forever.

    Intra-Workout Supplementation Will Change The Way You Build Muscle.
    + Click To Enlarge.
    Intra-Workout Supplementation Will
    Change The Way You Build Muscle.

      In a groundbreaking clinical study conducted at Australia's Charles Sturt University, researchers analyzed the effects of intra-workout supplementation. Test subjects consumed a 6 percent liquid carbohydrate and 6 grams of essential amino acid solution during their workout and were evaluated for hormonal and muscular adaptations as well as biochemical response.

      After 12 weeks, the results were astounding! When compared to the placebo group, test subjects packed on more muscle (9.04 vs. 3.97 lbs.) than the placebo group. Muscle fiber expansion across Type I, Type IIa and Type IIb muscle fibers was also significantly increased.4

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      These type of gains in muscle will definitely increase your quality mass. As if this statistic alone isn't enough to convince you of the benefits of intra-workout supplementation, test subjects also increased their max leg press strength by 39 percent more than the placebo group (463 vs. 334 lbs.).

    Reduce Catabolic Hormone Concentration Levels

      As was mentioned earlier, the physical trauma that bodybuilders put themselves through during each agonizing training session facilitates hypersecretion of a catabolic hormone, which causes unwanted muscle breakdown. However, in another clinical study, subjects who supplemented intra-workout actually decreased serum [of the catabolic hormone] concentration levels from pre-workout to 30 minutes after exercise by 23 percent - preventing excessive catabolic response (317.1 vs. 245.4 nmol/L). 5

    Subjects Who Supplemented Intra-Workout Actually Decreased Serum Of The Catabolic Hormone Concentration Levels.
    + Click To Enlarge.
    Subjects Who Supplemented Intra-Workout Actually
    Decreased Serum Of The Catabolic Hormone Concentration Levels.

      By initiating peak anabolic response and sustaining maximum glycogen levels during intensive training, your in-gym performance will dramatically increase as your muscle size and strength hit plateau-smashing levels.

      With the overwhelming scientific evidence supporting the muscle-building benefits of intra-workout supplementation, you can be confident that you'll achieve real results fast!


    1. Chesley, A., MacDougall, J.D., Tranopolsky, M.A., Atkinson, S.A., Smith, K. (1992). Changes in human muscle protein synthesis after resistance exercise. Journal of Applied Physiology, 73, 1383-1388.
    2. Biolo, G., Maggi, S.P., Williams, B.D., Tipton, K.D., Wolfe, R.R. (1995). Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans. American Journal Physiological Endocrinol Metabolism, 268, E514-E520.
    3. Bird, P. Stephen, et al. (2006). Liquid carbohydrate/essential amino acid ingestion during an acute bout of resistance exercise suppresses myofibrillar protein degradation. Metabolism Clinical and Experimental, 55, 570-577.
    4. Bird, P. Stephen, et al. (2006). Independent and combined effects of liquid carbohydrate/essential amino acid ingestion on hormonal and muscular adaptations following resistance training in untrained men. European Journal of Applied Physiology, 97, 225-238.
    5. Bird, P. Stephen, et al. (2006). Effects of liquid carbohydrate/essential amino acid ingestion on acute hormonal response during a single bout of resistance exercise in untrained men. Nutrition, 22, 367-375.

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