1. Internal Cleansing Blend

Indole-3-carbinol (I3C) - Is a micronutrient compound found in cruciferous vegetables including broccoli, cabbage, and cauliflower. When IC3 molecules come into contact with stomach acids, they can combine to form biologically active compounds, which research suggests may promote liver and gut detoxification.*

Calcium-D-glucarate - Glucaric acid is found in many fruits and vegetables, with the highest concentrations in oranges, apples, grapefruit, and cruciferous vegetables. Calcium-D-glucarate supplements have been shown to inhibit beta-glucuronidase, an enzyme that is produced by colonic microflora and involved in liver detoxification.*

Pomegranate extract - Is rich in Vitamin C, nutrients, iron, and minerals; it is also a natural and potent antioxidant. All parts of the pomegranate fruit have been used in Ayurvedic medicine for thousands of years for a variety of health benefits.  Recent studies have also shown that pomegranate seed oil may help support a healthy lipid profile.*

Polygonum Cuspidatim Extract - Also known as Japanese knotweed, has been used for centuries by herbalists for its astringent, coagulant, and diuretic properties. Scientific studies have shown that the high concentration of resveratrol provides antioxidant effects to help the body fight free radicals that may cause lipid peroxidation that results in cell damage.*

Olive leaf extract - The health benefits of this ingredient are attributed to its natural polyphenols, flavonoids, and antioxidants.*

Artichoke extract - The key components of artichoke extract, caffeoylquinic acids, have been shown to enhance detoxification reactions and protect the liver.*

Nettle leaf - Is an antioxidant that has traditionally been used as a blood purifier, cleansing and detoxifying agent, and as a support for urinary tract health.*

Hyssop leaf - Contains antioxidant phytochemicals, including caffeic acid, to help prevent free radical damage in the body.  It has also been historically used to help soothe irritated digestive tract.*

Fennel seed extract - Has demonstrated inhibitory effects on the growth of numerous bacteria. This antibacterial effect may be the reason this ingredient has traditionally been used to soothe and support the digestive system.*

Garlic bulb - (Deodorized) Studies have demonstrated that it is effective as an antimicrobial agent against bacteria, viruses, worms, and fungi. Garlic also stimulates the digestive organs and may help with problems associated with poor digestion.*

Ginger root extract - Ginger root has been used for thousands of years to help soothe nausea and upset stomach, and has been shown in research studies to help support gastric emptying, which can help promote the detoxification process.*

3. Liver Cleansing Blend

Milk thistle extract – Helps promote normal liver function. The extract has been used by various cultures for centuries.  Research has shown that silymarin, its active bioflavonoid complex, acts as a powerful antioxidant that helps protect the liver.*

Turmeric extract - Contains several compounds that  protect the liver, and stimulates bile from the liver. The compound curcumin has particularly been identified as having beneficial activity on liver function.* 

Green tea extract - Has long been established as a source of potent antioxidants.  Research has also shown that green tea extract provides antioxidant protection to the liver and help support detoxification.*

N-Acetyl-N-Cysteine - A derivative of the amino acid L-cysteine, has been used successfully in animal models to protect the liver from damage due to oxidative stress.*

FOS (Fructooligosaccharides) - Are plant sugars that also act as prebiotics. These compounds occur naturally in onions, garlic, asparagus, artichokes, and other vegetables.  FOS compounds are able to pass through the small intestine unaltered, where they are then metabolized in the large intestine to form compounds that are beneficial to the digestion process.*

Lactobacillus acidophilus - Often found in dairy products like yogurt, provides a probiotic effect that helps to maintain a range of normal bodily functions.  Probiotics help maintain normal digestion and support a healthy immune system. While Lactobacillus acidophilus is naturally found in the body, it can be reduced with antibiotics, stress, or other factors.*

Bifodobacterium bifidus - Is one of the major types  of bacteria that make up the colon.  It provides a probiotic effect and aids in healthy digestion.*

You & Improved

REFERENCES

Effect of indole-3-carbinol on ethanol-induced liver injury and acetaldehyde-stimulated hepatic stellate cells activation using precision-cut rat liver slices. Clin Exp Pharmacol Physiol. 2010 Dec;37(12):1107-13. doi: 10.1111/j.1440-1681.2010.05450.x.

Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans. J Natl Cancer Inst. 1997 May 21;89(10):718-23.

Badmaev, V., et al. "Piperine Derived from Black Pepper Increases the Plasma Levels of Coenzyme Q10 Following Oral Supplementation." J Nutr Biochem 11.2 (2000): 109-13.

Nho, CW, Jeffery, E. “The Synergistic Upregulation of Phase II Detoxification Enzymes by Glucosinolate Breakdown Products in Cruciferous Vegetables” Toxicology and Applied Pharmacology, 174.2 (2001): 146-152.

Walaszek Z, Hanausek-Walaszek M. “D-glucaro-1,4-lactone: Its Excretion in the Bile and Urine and Effect on Biliary Excretion of Beta-glucuronidase after Oral Administration in Rats.” Hepatology, 9 (1988): 552-556.

Selkirk JK, Cohen GM, MacLeod MC. “Glucuronic Acid Conjugation in the Metabolism of Chemical Carcinogens by Rodent Cells.” Arch Toxicol, 139 (1980): S171-S178.

Jurenka JS. “Therapeutic Applications of Pomegranate (Punica granatum L.): A Review.” Altern Med Rev., 13.2 (2008): 128-44.

Mirmiran P, Fazeli MR, Asghari G, Shafiee A, Azizi F. “Effect of Pomegranate Seed Oil on Hyperlipidaemic Subjects: A Double-blind Placebo-controlled Clinical Trial.” Br J Nutr., 25 (2010): 1-5.

“Antioxidant Activity of Extract from Polygonum aviculare.” L. Biol Res., 39.2 (2006): 281-8.

El SN, Karakaya S. “Olive Tree (Olea europaea) Leaves: Potential Beneficial Effects on Human Health.” Nutr Rev., 67.11 (2009): 632-8.

"Artichoke Extract: Improves Digestion, Liver Function, and Cholesterol Levels." Natural Medicine Journal, 1.7 (1998).

Bundy R, Walker AF, Middleton RW, Marakis G, Booth JC. “Artichoke Leaf Extract Reduces Symptoms of Irritable Bowel Syndrome and Improves Quality of Life in Otherwise Healthy Volunteers Suffering from Concomitant Dyspepsia: A Subset Analysis.” J Altern Complement Med., 10.4 (2004): 667-9.

Yarnell E. “Botanical Medicines for the Urinary Tract.” World J Urol., 20.5 (2002): 285-93. Epub 2002 Oct 17.

Konrad A, Mähler M, Arni S, Flogerzi B, Klingelhöfer S, Seibold F. “Ameliorative Effect of IDS 30, a Stinging Nettle Leaf Extract, on Chronic Colitis.” Int J Colorectal Dis., 20.1 (2005): 9-17. Epub 2004 Aug 25.

Miyazaki H, Matsuura H, Yanagiya C, Mizutani J, Tsuji M, Ishihara C. “Inhibitory Effects of Hyssop (Hyssopus officinalis) Extracts on Intestinal Alpha-glucosidase Activity and Postprandial Hyperglycemia.” J Nutr Sci Vitaminol (Tokyo)., 49.5 (2003): 346-9. (15) Ozcan MM, Sagdic O, Ozkan G. “Inhibitory Effects of Spice Essential Oils on the Growth of Bacillus Species.” J Med Food, 9.3 (2006): 418-421.

Schelz Z, Molnar J, Hohmann J. “Antimicrobial and Antiplasmid Activities of Essential Oils.” Fitoterapia, 77.4 (2006): 279-285. (17) Butt MS, Sultan MT, Butt MS, Iqbal J. “Garlic: Nature's Protection against Physiological Threats.” Crit Rev Food Sci Nutr., 49.6 (2009): 538-51.

(“Antiinflammatory, Analgesic and Antioxidant Activities of the Fruit of Foeniculum vulgare.” Fitoterapia, 75.6 (2004): 557-65.

Hughes BG and Lawson L. “Antimicrobial Effects of Allium sativum L. (Garlic), Allium ampeloprasum L. (elephant garlic), and Allium cepa L. (onion), Garlic Compounds and Commercial Garlic Supplement Products.” Phyther Res, 5 (1991): 154-1588.

Barowsky, H, Boyd LJ. “The Use of Garlic (Allistan) in Gastrointestinal Disturbances.” Rev Gastroenterol, 11 (1944): 22-26.

Ajith TA, Hema U, Aswathy MS. “Zingiber officinale Roscoe Prevents Acetaminophen-induced Acute Hepatotoxicity by Enhancing Hepatic Antioxidant Status.” Food Chem Toxicol., 45.11 (2007): 2267-72. Epub 2007 Jun 9.

Nievergelt A. Huonker P. Schoop R. Altmann KH. Gertsch J. “Identification of Serotonin 5-HT1A Receptor Partial Agonists in Ginger.” Bioorganic & Medicinal Chemistry, 18.9 (2010): 3345-51.

Wu KL, Rayner CK, Chuah SK, Changchien CS, Lu SN, Chiu YC, Chiu KW, Lee CM. “Effects of Ginger on Gastric Emptying and Motility in Healthy Humans.” Eur J Gastroenterol Hepatol., 20.5 (2008): 436-40.

Yang H, Xu LN, He CY, Liu X, Fang RY, Ma TH. “CFTR Chloride Channel as a Molecular Target of Anthraquinone Compounds in Herbal Laxatives.” Acta Pharmacol Sin., 32.6 (2011): 834-9. Epub 2011 May 23.

Rajasekaran S, Sivagnanam K, Subramanian S. “Modulatory Effects of Aloe vera Leaf Gel Extract on Oxidative Stress in Rats Treated with Streptozotocin.” J Pharm Pharmacol., 57.2 (2005): 241-6.

Duke, James A. The Green Pharmacy, St. Martin’s Paperbacks, 1977. pg 174, 175.

Laxatives and the special role of senna. Pharmacology. 1988;36 Suppl 1:230-6.

Safety and efficacy of a bulk laxative containing senna versus lactulose in the treatment of chronic constipation in geriatric patients. Pharmacology. 1993 Oct;47 Suppl 1:253-5.

Valle-Jones JC. “An Open Study of Oat Bran Meal Biscuits ('Lejfibre') in the Treatment of Constipation in the Elderly.” Curr Med Res Opin., 9.10 (1985): 716-20.

Pectin digestion in humans. Am J Clin Nutr. 1983 Feb;37(2):253-5.

Linus Pauling Institute at Oregon State University. “Chlorophyll and Chlorophyllin”

Milk thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol. 1998 Feb;93(2):139-43.

Kim SH, Cheon HJ, Yun N, Oh ST, Shin E, Shim KS, Lee SM. “Protective Effect of a Mixture of Aloe vera and Silybum marianum against Carbon Tetrachloride-induced Acute Hepatotoxicity and Liver Fibrosis.” J Pharmacol Sci., 109.1 (2009): 119-27.

Rivera-Espinoza Y, Muriel P. “Pharmacological Actions of Curcumin in Liver Diseases or Damage.” Liver Int., 29.10 (2009): 1457-66.

Hamden K, Carreau S, Marki FA, Masmoudi H, El Feki A. “Positive Effects of Green Tea on Hepatic Dysfunction, Lipid

Peroxidation and Antioxidant Defence Depletion Induced by Cadmium.” Biol Res., 41.3 (2008): 331-9. Epub 2009 Apr 23.

Baumgardner JN, Shankar K, Hennings L, Albano E, Badger TM, Ronis MJ. “N-acetylcysteine Attenuates Progression of Liver Rat Model of Nonalcoholic Steatohepatitis.” J Nutr., 138.10 (2008): 1872-9.

Sabater-Molina M, Larqué E, Torrella F, Zamora S. “Dietary Fructooligosaccharides and Potential Benefits on Health.” J Physiol Biochem., 65.3 (2009): 315-28.

Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: a double-blind study. J Clin Gastroenterol. 2011 Jul;45(6):518-25.

Preventive effects of Bifidobacterium- and Lactobacillus-fermented milk on the development of inflammatory bowel disease in senescence-accelerated mouse P1/Yit strain mice. Digestion. 2001;64(2):92-9.