Citrulline, 200 Grams Unflavored
L–Citrulline is an amino acid that has been found to play an important role in nitric oxide (NO) metabolism and regulation. L-Citrulline is converted to L-Arginine in the body, leading to increases in both L-Arginine and nitric oxide. Increased production of nitric oxide promotes vascular dilation, which helps support normal oxygen and blood circulation throughout the body.
The pharmacokinetic advantage of L-Citrulline is that it is not subject to any elimination by the liver prior to entering the bloodstream. Conversely, L-Arginine is subject to extensive elimination by the gut wall and liver. (26)
The majority of L-Citrulline is converted to L-Arginine in the kidney. (3)
Once in circulation, L-Arginine is readily converted into L-Citrulline and nitric oxide, which in turn serves as an L-Arginine precursor (see figure below). (10)
arg (L-arginine) to cit
absorption of l-arginine and l-citrulline
Inside intestinal tract
Consumed in the urea cycle and in biosynthesis of other substances in liver
Reaches kidney through liver, biosynthesis of ARG in Kidney (75%)
ARG supplied to the whole body
*CIT ingestion enables effective supply of ARG to the whole body
roles of cit in the body
- Influences on blood vessels: Actions via NO production, vasodilation, blood flow acceleration*
- Ammonia detoxification: Action as a component of the L-ornithine cycle*
- Antioxidant effect: An active oxygen radical scavenger (potent quencher of hydroxyl radical)*
* Citrulline Malate is mixed 1:1 (Malic Acid + L-Citrulline. basically, THE L-Citrulline is cut in half!
** Most brands use Citrulline Malate 1:1 ratio due to cost (cheap) – 50% less per kg than pure L-Citrulline.
benefits of kaged muscle l-citrulline
- fermentation derived vs synthetic*
- gras approved
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What's in Kaged Muscle Citrulline
Directions For Citrulline: As a dietary supplement, mix 1 scoop in your favorite beverage or protein shake twice daily.
Warnings: Consult your physician prior to using this product if you are pregnant, nursing, under 18 years of age, taking medication or have a medical condition. Immediately discontinue use and contact your physician if any adverse reactions occur. Keep out of reach of children. Store in a cool dry place away from excessive heat. Serving scoop included (may settle to the bottom during shipping.)