The original formula laid down the base for what I wanted to achieve for TestoBoost and that was to naturally support testosterone levels in both men and women. The pathways that I targeted included stimulating all the relevant areas of the hypothalamic-pituitary-testicular axis (HPTA) through several independent mechanisms.* Subsequent versions of TestoBoost, while keeping the base intact, added several ingredients that I felt would further increase testosterone levels, and further decrease any potential side effects.*
The basis of the formula in TestoBoost, and in all the MD+ formulations, is to involve all possible pathways that lead to the desired effects, and to use multiple ingredients that work together to produce superior results. In the case of TestoBoost the desired effect was to support basal and elevated testosterone levels in the body, and a salutary effect on overall health.*
All of this can be accomplished by using ingredients that are known or suspected to boost testosterone.*
For example, using a variety of ingredients to effectively act as a testosterone sink by trapping testosterone production is the most effective way to increase endogenous androgen production. In order to do this you have to consider all the possible pathways that are involved in maximizing testosterone production, including:
- Supporting luteinizing hormone (LH) production.*
- Promoting the effect of LH.*
- Supporting testicular steroidogenesis directly.*
- Decreasing inhibitors of steroidogenesis.*
- Providing vitamins and minerals that might be frankly or marginally deficient and thus not allowing the full production of testosterone - e.g. magnesium, zinc, B6.
- Supporting peripheral formation of testosterone.*
- Promoting a healthy estrogen balance.*
On top of this TestoBoost contains bioperine, which significantly enhances the bioavailability of supplemented nutrients through increased absorption.*
The list of ingredients that could prove useful for supporting testosterone levels is long and includes various vitamins such as vitamin A, B6 and E, minerals such as zinc, magnesium, manganese, and other ingredients such as arginine, beta ecdysone boron, calcium-d-glucarate, catuaba bark, chasteberry (vitex agnus-castus), chrysin, co-enzyme q10 (ubiquinone), forskohlin, damiana, 5-methyl methoxy isoflavone, deer antler extract, eurycoma longifolia, genistein, GLA, glutathione, prickly pear extract, indole-3-carbinol, ipriflavone, maca root, muira puama, quercetin dihydrate, saw palmetto, schisandra chinensis, stinging nettle extract and tribulus terrestris.*
Using testosterone and/or anabolic steroids to increase your levels of androgens in your body is also the wrong way to approach the problem of low systemic testosterone levels. For example, use of exogenous testosterone shuts down the hypothalamicpituitary-testicular axis (HPTA) that controls testosterone production on the body.*
The bottom line is that whatever your reasons for wanting physiologically increased levels of testosterone, TestoBoost is the best way to go.
New Version of TestoBoost
My reasons for reformulating include:
- The use of new scientific information.
- The use of information from athletes who found certain ingredients useful.
- The use of information from personal clinical studies on the effectiveness of adding certain ingredients to the present formulation.
- Feedback from colleagues and others who have used the product, including their subjective results and blood work.
- Support testosterone*
- Promote estrogen balance*
- Support healthy libido in both men and women*
- Support an anabolic effect*
- Decrease body fat when combined with diet and exercise*
TestoBoost is useful for anyone who wants to naturally support their testosterone levels in order to increase muscle mass and strength.*
Changes in TestoBoost v3.0
A number of ingredients have been added to the TestoBoost formula. TestoBoost was already a very popular and effective supplement and very few of the original ingredients have been altered. The only changes that have been made to the original ingredients is that the amount of vitamin A was dropped to 2,000 IU from 5,000 IU. On the other hand, several new ingredients have been added, as outlined below.
Vitamin A (as palmitate)
This was decreased from 5,000IU to 2000 IU. There are several reasons for this. The main one, however, is that while vitamin A is important for the maximal production of testosterone, overdoing it can have negative and sometimes toxic effects. I take into consideration the impact of all the ingredients in my MD+ line so that if someone were to use all of them they would not overdose on any one ingredient. Vitamin A is one of those ingredients and since it's in several of the MD+ supplements, the amount in TestoBoost was decreased.
5,000 IU of this was added to the formula, both because of its antioxidant properties, but also because the body can manufacture vitamin A from it. Thus is there is a deficiency of vitamin A to the point where the 2000 IU in TestoBoost isn't enough, the body can make what it needs.Vitamin B12 (as methylcobalamin) I increased this from 50mcg to 100 mcg. As well, methylcobalamin is used in the new formula as against cyanacobalamin in the former one. Methylcobalamin is the biologically active form of B12, whereas cyanacobalamin is the synthetic form. The body has to change the cyanacobalamin into methylcobalamin. This process may be compromised in some people so using the metabolically active form is more efficient and improves bioavailability and function. B12 helps to optimize macronutrient metabolism, maximize muscle mass and decrease body fat. Magnesium
A combination of magnesium salts (aspartate, oxide and octadecanoate) were incorporated to take the place of the magnesium oxide. While most of the magnesium is in the form of the aspartate (the form that has been shown influence testosterone levels and is the ingredient that is ZMA, along with zinc monomethione and B6, which are also in TestoBoost). Magnesium in the form of oxide and octadecanoate are also included as both sources of magnesium and to make the tablets more cohesive and less susceptible to breaking in transport.
Arginine alpha-ketoglutarateThis compound has several important effects. First of all it moderately increases nitric oxide (NO), and secondly it supports growth hormone secretion.*
Some extra aspartate was added to increase the aspartate content of TestoBoost for two reasons. First of all aspartate has been suggested to increase testosterone production in murine models.1 Also as this compound has significant metabolic effects, including AMP production, improving the salvage of ATP from in muscle cells, and also acts as an anaplerotic precursor and thus increases TCA flux and ATP formation. This aids in the synthesis of hormones, including testosterone.
5-Methyl Methoxy Isoflavone
Methoxy Isoflavone has been suggested to support protein synthesis in animal models, including livestock, with no significant side effects. Anecdotal evidence over the past year has shown that it may exhibit some mild anabolic support.* Similarly ecdysone, also known as beta ecdysterone and 20 beta hydroxyecdysterone, has shown to have some anabolic effects.
Ecdysone (beta ecdysterone, ecditen, 20 beta hydroxyecdysterone)
Ecdysone was popular with Olympic lifters and other athletes in the East and several quasi scientific studies, 2 which were never published, showed that it might have significant anabolic effects.2 Real world use has not shown dramatic effects and most of the information is available through nutritional companies that vastly overstate the anabolic properties of ecdysone. Nevertheless it makes a useful synergistic ingredient for TestoBoost even though on its own its effects are minimal.
Deer Antler Extract
Velvet deer antler extract has been used in the Orient, and in Russia as an anabolic agent for athletes. Anecdotal evidence again shows that it may have some effect on increasing serum luteinizing hormone and testosterone levels, with no significant side effects. As such, it works synergistically with other ingredients in TestoBoost that work in similar ways, especially tribulus terrestris.*
Eurycoma Longifolia (Longjack)
Longjack has been used in the Orient to support sexual health.* While formal studies have not been done in humans, recent informal ones on murine models have shown that Longjack may support free serum testosterone levels.3,4 As such, it works synergistically with other ingredients in TestoBoost that work in similar ways, including acetyl-L-carnitine, catuaba bark, maca root, coleus forskohlii (forskolin), muira puama, chasteberry (vitex agnuscastus - ecdysteroids), suma root (beta ecdysone - also known as beta ecdysterone and 20 beta hydroxyecdysterone), schisandra chinensis, and avena sativa.
As well, ALCAR seems to have an effect on the hypothalamic-pituitary-testicular axis. Studies have shown that ALC prevented the decrease in plasma testosterone levels after chronic swimming6, and that ALC stimulates testosterone production7.
Genistein (4',5,7-trihydroxyisoflavone), a major isoflavone in soybeans and a specific inhibitor of protein tyrosine kinase. A recent study has shown that there is a synergistic effect of indole-3-carbinol and genistein.8 As well as these two ingredients, TestoBoost also contains other compounds including calcium-d-glucarate,9 chrysin and ipriflavone.10,11 The addition of bioperine increases the absorption of these and other ingredients increasing the biological synergistic effects that may help support a healthy estrogen balance.*
Prickly Pear Extract *
This extract is felt to have neuroprotective and antioxidant effects. Also has insulin like effects and has been shown to have a favorable effect on cholesterol in the body. There is some anecdotal evidence that the use of prickly pear acts as an adaptogen.
Schizandra is a woody vine with clusters of red berries that is found in northern and ortheastern China and adjacent regions in Russia and Korea. Athletes have used schisandra in the belief that it will increase endurance and combat fatigue under physical stress.12 It is also felt to have liver protective effects.
Health Benefits and Protective Effects of TestoBoost
Although TestoBoost is formulated to increase testosterone levels and enhance anabolism, it's also formulated to provide substantial health benefits. For example it has several ingredients, including saw palmetto (serenoa repens), zinc, quercetin, GLA (in borage oil) and stinging nettle that may support prostate health in males.*
Some of these ingredients also decrease the formation of dihydrotestosterone from testosterone,13 thus maximizing testosterone levels while at the same time decreasing the adverse effects of higher systemic and tissue levels of dihydrotestosterone.14
TestoBoost also contains several antioxidants, such as alpha lipoic acid, beta carotene, vitamin C, vitamin E, Coenzyme Q10, and turmeric, which act to improve pituitary and testicular/ovarian function, and decrease the adverse effects of free radicals on the hypothalamic-pituitary-testicular/ovarian axis, and the associated pathways that are responsible for maximizing endogenous testosterone production.
Alpha lipoic acid (ALA) has a double antioxidant effect as it has significant antioxidant properties on its own, but also regenerates glutathione, the most important endogenous antioxidant.16
TestoBoost also contains several other vitamins, minerals and nutrients that are important for optimizing testosterone levels. These include vitamin A, vitamin B6, vitamin B12, niacin, calcium, magnesium, manganese, boron, zinc, ginger and Coenzyme Q10.
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9 Calcium-D-glucarate. Altern Med Rev. 2002 Aug;7(4):336-9. 10 Chen S, Kao YC, Laughton CA. Binding characteristics of aromatase inhibitors and phytoestrogens to human aromatase. J Steroid Biochem Mol Biol. 1997 Apr;61(3-6):107-15.
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12 Ahumada F. Et al (1989) Studies on the effect of Schisandra chinensis extract on horses submitted to exercise and maximum effort. Phytotherapy Res. 3(5):175.
13 Pham H, Ziboh VA. 5 alpha-reductase-catalyzed conversion of testosterone to dihydrotestosterone is increased in prostatic adenocarcinoma cells: suppression by 15-lipoxygenase metabolites of gammalinolenic and eicosapentaenoic acids. J Steroid Biochem Mol Biol. 2002 Nov;82(4-5):393-400.
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15 Sen Gupta R, Sen Gupta E, Dhakal BK, Thakur AR, Ahnn J. Vitamin C and vitamin E protect the rat testes from cadmium-induced reactive oxygen species. Mol Cells. 2004 Feb 29;17(1):132-9.
16 Patrick L. Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity. Altern Med Rev. 2002 Dec;7(6):456-71.