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The Skinny On Sweet: The Truth About 4 Common Artificial Sweeteners

Just because it is calorie free doesn't mean it's a free-for-all. Learn the lingo and serving suggestions for four common sugar substitutes.

Type "artificial sweetener" into any Internet search engine and expect to be inundated with a barrage of false claims. These unsubstantiated side effects include (but are certainly not limited to): anxiety, blindness, obesity, suicidal ideation, epilepsy, Alzheimer's, multiple sclerosis, hypothyroidism, chronic fatigue, personality changes, elevated blood pressure, migraines, hypoglycemia, menstrual abnormalities, and "irreversible brain damage." Yikes! Still with us?

Numerous studies have investigated the supposed link between consuming fake sugars and suffering from these symptoms, but few have found any direct links. Yet accusations that sugar substitutes are the root cause of countless health problems pervade. But is there actually a cause for concern? And how can we be sure?

Sweet Poison? — The Need-to-Know

Like any flavor enhancer, artificial sweeteners only sneak into snacks, beverages, and other goods after passing a rigorous approval process conducted by the FDA. Based on reviews of its chemical formula and all existing research into its effects on animals and humans (i.e. whether it's toxic, could possibly cause cancer, or could cause the growth of extra limbs), scientists determine how much of a sweetener humans can safely consume on a daily basis—a measure known as acceptable daily intake, or ADI.

The FDA (or other regulatory agencies) typically draws this line 100 times below the dose at which a substance could actually cause harm. So not only are we dealing with a huge safety margin to begin with, we're talking daily consumption over a lifetime—a fair bit more than the amount we could consume during a one-time synthetic sugar binge.

The Contenders

There are four artificial sweeteners currently on the U.S. Market: aspartame, acesulfame potassium, saccharin, and sucralose. And a new sweetener, by the name neotame, just received FDA approval and will soon join the ingredient lists of many low-cal and diet products. Ordered from lowest to highest ADI, here are the most commonly used artificial sweeteners on today's U.S. market.

Saccharin ///
(Sweet'N Low, SugarTwin)

More than 300 times sweeter than regular sugar, saccharin is one of the oldest and most widely studied artificial sweeteners. Chemist Constantin Fahlberg first discovered the stuff in 1879 when, after a long day at the lab, everything he touched at dinner suddenly tasted sweeter. Despite heavy criticism, the FDA has approved saccharin on multiple occasions. Warning labels were placed on all saccharin-containing products between 1997 and 2000 while the substance underwent further FDA review in response to concerns that the stuff could cause tumors in humans. As soon as more research indicated the substance was safe, all warnings were removed.

  • Where it's found: Chewing gum, diet soda, jams, salad dressings, candy, canned fruit, baked goods, some vitamins and pharmaceuticals, and cosmetics.
  • How much is too much? Saccharin's ADI clocks in at 5 milligrams per kilogram of body weight per day—the equivalent of a 150-pound person eating nine packets of Sweet N' Low. (OK, depending on the day, maybe some of us could get to this point ...)
Sucralose ///
(Splenda)

More than 100 studies have helped affirm sucralose's safety since it was created in the late 1960s. In one study, rodents exposed to 16,000 milligrams of sucralose per kilogram of their body weight per day—the equivalent of a human chugging 16,000 cans of diet soda (!?)—showed no significant side effects, nor did a group of diabetic people who consumed 500 milligrams of the stuff per day.

  • Where it's found: Yogurt, protein bars, frozen deserts, syrups, baked goods, and diet beverages.
  • How much is too much? Like saccharin, sucralose's ADI is 5 milligrams per kilogram of body weight per day. So a 165-pound-person could (in theory) safely snack on 31 packets of Splenda per day. (Blech.)
Acesulfame Potassium ///

Another accidental discovery, this sweetener gained approval in 1983, a couple decades after German Chemist Karl Claus just so happened to lick his chemically doused fingers in a lab one day to discover the compound. (Sound familiar, saccharin?) Rather than standing on its own, acesulfame potassium (200 times sweeter than regular sugar) is usually combined with aspartame or saccharin to enhance the flavors of low-cal treats and mask other artificial sugars' bitter aftertastes.

  • Where it's found: Soft drinks, diet iced teas, tabletop sweeteners, candies, and chewing gum, marinated fish (wait ...), rice pudding, ice cream, yogurt, and pickled vegetables (huh?). See also: toothpaste, mouthwash, and some medications.
  • How much is too much? On its own, acesulfame potassium has an ADI of 15 milligrams per pound of body weight. That's about as attainable as downing oh, say, 4,930 Coke Zeros between breakfast and bedtime. (Please don't consider this a challenge.)
Aspartame ///
(Equal, NutraSweet)

Surpassing saccharin as the most extensively researched and widely used artificial sweetener, aspartame was also discovered by a chance finger lick. (Clearly we'd be on different career paths had we also blatantly ignored Chemistry 101's lab rules.) Aspartame, which can taste up 220 times sweeter than natural sugar, entered the mainstream market after gaining FDA approval in 1974. It was reapproved in the early 1980s after additional studies disproved numerous claims over its adverse health effects.

  • Where it's found: Aspartame is currently used in more than 6,000 American products, ranging from soft drinks and candy to yogurts, deserts, fruit spreads, nutrition shakes, protein bars, cereals, gum, and some pharmaceuticals.
  • How much is too much? Aspartame's ADI stands at 50 milligrams per kilogram of body weight. To exceed this amount, a 150-pound adult would need to down more than twenty 12-ounce cans of diet soda. (Even the most enthusiastic aspartame consumers across the U.S., one study found, only down about the amount equal to three diet sodas per day for our 150-pound friend.)
Neotame ///
(Sweetos)

A close cousin of aspartame, this flavor enhancer clocks in with a sweetness between 7,000 and 13,000 times that of regular sugar. Yeesh! Neotame withstands higher temperatures and has a longer shelf-life than aspartame, and it's been proven safe in a number of clinical trials conducted in mice, rats, dogs, and rabbits. NutraSweet holds a patent for the stuff, and it's been gaining steam in India under the brand name Sweetos.

  • Where it's found: Though neotame received FDA approval in 2002, it hasn't yet been used in U.S. products. So stay tuned ...
  • How much is too much? Given that neotame is between 7,000 and 13,000 times sweeter than regular sugar, it's safe to say that no one is expected to need—or want? —to consume too much of it. Neotame's ADI has been set just less than 2 milligrams per kilogram of body weight per day, but since it's not yet on any ingredient lists, we can't give you some outlandish equivalent. (Sigh.)

Say What, Science? — The Answer / Debate

By and large, the major claim against artificial sweeteners—that they cause cancer—has been disproven. Several studies have found higher incidences of bladder cancer in rats whose chow was pumped full of aspartame. But we're talking the human equivalent of 2,500 to 5,000 milligrams per kilogram of body weight per day—way above aspartame's ADI and more than the typical amount of aspartame an average American is thought to consume. Plus, humans don't as readily form the potentially cancer-causing calcium crystals that rats do after breaking down artificial sweeteners (and other substances). (As it turns out, overloading on vitamin C is just as likely as swallowing too much saccharin to trigger bladder cancer in our rodent friends.)

The second biggest cause of sugar substitute debate? Whether they can cause weight gain. Research into this claim's validity is still a bit iffy. While some studies suggest artificial sweeteners screw up our brain's ability to gauge how many calories are in non-diet foods, others have found associations between long-term consumption of diet sodas and some seriously expanded waistlines. However, most emphasize a lack of proof that artificial sweeteners are the true culprits behind obesity. Since diet sodas and snacks are so widely consumed, the chances are pretty high that just about anything else (like ordering a Big Mac to go with that Coke Zero or counting TV remote clicks as exercise) could be the real source of the pudge.

And what about claims that aspartame causes dizziness, nausea, fatigue, headaches, and mood problems? That could just be a consequence of crash dieting, says M.D. Peter Sedesse. "If people who drink about 50 percent of their overall calories from regular soda suddenly switch to Diet Coke, it's the same as you or I suddenly eating almost nothing," Sedesse explains, via email. "All of those issues—including confusion, poor memory, fatigue, irritability, mood swings, sluggishness, and depression—happen when the brain and body don't get enough calories to function normally."

The Takeaway

Though all five currently produced artificial sweeteners have met (and surpassed) the FDA's current safety standards for food additives, there's no definitive guarantee that these products will never be found to pose health risks. The formerly legal sweetener cyclamate, for instance, was banned from incorporation into foods, beverages, and sweetening tablets after a study found it to be toxic to some animals. Though, word to the scientifically wise: Subsequent studies have not replicated the tumor-cyclamate link.

But, like most things, artificial sweeteners come with legit cons and pros.

On the plus side, they can help keep caloric intake under control, reduce insulin spikes and post-sugar binge crashes, make medicines and oral hygiene products less bitter, and boost yumminess in some food and beverages. On the other (not-so-plus) side, they don't provide any vitamins, minerals, protein, fiber, or healthy fats. It's no news that weight control and overall health maintenance involve more than just cutting calories. Optimal well-being means incorporating a range of non-processed and proven-to-be-good-for-you options into your daily diet—think veggies, fruits, lean protein, fish oils, and whole grains. Not to mention adopting a healthier lifestyle that includes regular physical activity and adequate sleep.

In turn, while the vast majority of us may not be adversely affected by sugar substitutes, some may have their own issues. One genetic disorder, for instance, renders sufferers unable to metabolize one of aspartame's metabolic byproducts, the essential amino acid phenylalaline. Many folks may also have specific allergies to artificial sweeteners, much like they would to a variety of foods or chemicals. Be your own sleuth. If you get hives after drinking diet soda on multiple occasions, try taking a break from the Pepsi Maxx and speak with a doctor.

No one's recommending a diet of Equal packets and Powerade Zero—just because non-nutritive sugar substitutes aren't so bad for you after all doesn't mean they're good for you. But until sufficient evidence crops up that any of the above sweeteners do pose a significant risk to human health, there's no scientifically sound reason to take them off the market—or to eliminate them from your diet.

Do you use artificial sweeteners? If so, how much? What's your stance on their safety? Join the conversation in the comments below!


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tpetro

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tpetro

I use stevia

Jul 30, 2013 5:52pm | report
Kovenant

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Kovenant

That other marketing bad sugar, and when you use it, you crave more also for regular sugar and stevia has a really bad after taste.

Jul 30, 2013 7:07pm | report
20fourseven

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20fourseven

unlike the above artificial sweeteners(thousands of complainants have been filled against these artificial sweeteners), stevia has virtually none such complaints. Just because FDA(federal death association) approve something does not make it safe,healthy or even safe as we have seen over time. They only stand for elite companies

Jul 30, 2013 8:34pm | report
plmcute8402

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plmcute8402

Amen 20four! The FDA is a joke- look at what they say is "safe" to put into water and spray on produce,personally id rather have a bug bite into my carrot then eat something thats been srayed with chemicals you have to handle with protective gear-

Jul 31, 2013 7:44am | report
BerserkElite

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BerserkElite

@pimcute. Agreed. At least bugs provide protein. ;D

Jul 31, 2013 8:02pm | report
RipChudd

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RipChudd

Right on @20fourseven. The FDA approves Aspatame even though it causes Cancer in rats by a very high percentage.

Jul 31, 2013 9:56pm | report
XxmetallicaxX

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XxmetallicaxX

All in all everything is okay for you in the right amount, even steroids, its when you start abusing and letting things control you.....that's when its bad for you

Jul 30, 2013 6:59pm | report
aenemus

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aenemus

It's when you take steroids that you are exceeding the amounts, you body produces the necessary.

Jul 31, 2013 9:24am | report
Kovenant

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Kovenant

only a little "D-bol" of 5mg has more steroid hormone that your body produce. We our body produce in ng not in mg or grams.

Jul 31, 2013 6:13pm | report
Jerky769

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Jerky769

Loved it... good read.

Jul 30, 2013 7:38pm | report
21acejack

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21acejack

Sparingly, and only 1/2 - 1 packet with Iced Tea. I've contemplated using these artificial sweeteners because of these rumors. I use sugar, only a pack or two but the tea still taste the same. I am still unsure as I also like to keep sugarlevels down.

Jul 30, 2013 8:22pm | report
plmcute8402

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plmcute8402

try using raw sugar(golden brown color) or honey

Jul 31, 2013 7:46am | report
jayradwv

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jayradwv

Agree with plmcute8402. Raw, local honey has many health benefits, and adds a nice thickness to a protein shake.

Sep 22, 2013 8:11pm | report
mastiffsrule

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mastiffsrule

None of these should be used. Honestly you're better off eating actual sugar instead. These chemicals provide false chemical signatures that ***** with your insulin. Not to mention side effects- migraines, nausea, hives, onset of rheumatoid, bursitis, and gout. What no one studies is how these chemicals are broken down and used in your body AFTER you eat them. I've spent enough time in the doctor's office because of these chemicals, thank you.

Jul 30, 2013 9:03pm | report
RaneyR

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RaneyR

This is good stuff. I've heard a bunch of bull lately about artificial sweeteners, but the conclusion sums up my thoughts: Not good for you, but not bad for you.

Jul 30, 2013 9:34pm | report
tuhsteh

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tuhsteh

i feel like if you are considering a sugar-substitute, then step back and think about why in the first place. If you're trying to make a cake healthy, are you not cheating by trying to eat cake? i do drink diet soda once in a while, but after years of practice, the desire to eat things that need a sugar substitute has shrunk by quite a bit.

Jul 30, 2013 10:25pm | report
dul

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dul

Aspartame??? Come on guys how can you even think about putting it down??

Jul 31, 2013 4:02am | report
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Gunna20

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Gunna20

Thanks for the info but I still won't touch that crap, the FDA sides with these companies because they provide them with plenty of cash.

Jul 31, 2013 6:29am | report
JonathanKSmith

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JonathanKSmith

Agreed. FDA approval means nothing to me. They also allow the import of tilapia from China that has been raised in sewage. Not to mention many dyes and preservatives that are banned in many other countries are approved by the FDA for American consumption. Be natural. If you have to have something sweet just use real sugar.

Jul 31, 2013 7:02am | report
JDa617

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JDa617

Everything is bad for you. If you aren't growing your own vegetables with your own manure, it's probably GMOs. So people stating that they don't touch sugar subtitutes are just being hypocritical. Because, I am pretty sure the "lean" meats are pumped full of hormones and the "fresh" vegetables were genetically altered. The thing is, where do you really start at having something completely untouched and not altered in anyway.

Jul 31, 2013 7:16am | report
JDa617

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JDa617

Oh and a lot of meats now have fillers in them. So make sure the foods you are buying are researched.

Jul 31, 2013 7:18am | report
Anchovy007

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Anchovy007

This is the most knowledgable comment on this whole article. I could not agree more.

Aug 1, 2013 8:23am | report
cornejomiguel

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cornejomiguel

Amen!! Finally somebody with common sense..

Aug 3, 2013 7:28pm | report
AKPisMe

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AKPisMe

Although still not 100% full-proof, if you pay the extra 33% for the USDA organic label, you're taking care of many of the issues you speak of. Local is always good too.

Sep 16, 2013 9:17am | report
Carter505

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Carter505

Very informative article, yet I do not hold a lot of credence to the politically astute FDA.

Jul 31, 2013 7:36am | report
Showing 1 - 25 of 71 Comments

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