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Should I Take Casein Or Whey Protein?

Understanding the link between the structure and function of a particular muscle will help you to make the right decision, put together an intelligent program and start adding some high quality muscle mass.

By: Eric Satterwhite

Trying to decide on which proteins to use at what times and for what reasons can be a mind-numbing process.

It is my hopes that this article can shed some light on the subject. There are basically two major proteins in the bodybuilder's arsenal. Those being casein and whey. They are also sometimes referred to as slow and fast acting proteins, respectively.

The purpose of this article series is to give you an in-depth look at the properties of each of these proteins, explain what it all means and why it is important to you. And, finally, to provide a systematic way to apply it all.


The Myths

So, you've got a choice. Casein or whey? Fast or slow? Some people swear by one or the other and would have you believe that one of them is, in fact, superior.

Well, I am sorry to say that those people are just plain wrong. They either do not understand the literature, have a poor sense of critical application, or just want to make an impact by taking a stand. Whichever it may be, these people have misled you. And I can assure you that their path is nothing but a downward spiral to minimal results.

To truly get the most from your protein supplementation, you will need to utilize both types of protein in your repertoire of supplements. Let's expand on whey a little bit first. I like to start with whey because it is better known and many have some background understanding of it.

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The Facts

Whey

    Whey is a by-product of cheese production. When cheese is made, a thin liquid is left over. That liquid is whey and it is less than 1% protein. It is concentrated and dried, and you have a protein powder. Whey protein is considered a "fast acting" protein. But what, exactly, is meant by 'fast'?

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    Fast refers to the amount of time it takes to be fully metabolized. More specifically, the time it takes for it to be digested (if needed), absorbed into the blood, taken up by a bodily tissue, and complete one of many metabolic fates.

    The two dominant pathways here are the creation of a new protein from the individual amino acids or oxidation into urea and possibly glucose.

    Urea is the major component of urine, while glucose is the human basic unit of carbohydrate. With whey protein, it will take only 20 minutes before almost all of what you have consumed is coursing through your veins.

    Somewhere between 20-40 minutes, the level of amino acids in your blood has reached its high point. Within the hour it will have gone through the various metabolic processes, either protein synthesis, or oxidation.11,12,13,14

    This is a good thing! Muscle growth is dependant on the balance between protein synthesis and breakdown18. If the synthesis of new muscle protein is greater than the breakdown of muscle protein, net gains in muscle mass are seen.

    So with whey protein, it will take only 40 minutes for blood levels of amino acids and protein synthesis to reach a peak, and in about an hour they will come back to normal after a single feeding of protein.5,14 This is amazingly fast in comparison to its counterpart casein, or even whole food.

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Casein

    Casein is considered a "slow" protein. When you consume casein, you will reach a peak in blood amino acids and protein synthesis between 3 to 4 hours.5,12

    This peak, however, does not even come close to that of whey. On a scale of 1-10 (with 10 being the highest or fastest), whey would be a 10. Casein would come in with a meager rating of 2.

    But, here is the kicker. That is not a bad thing! This, too, is a good thing. Casein dramatically slows the rate of protein breakdown. Remember, muscle growth is dependant on the balance of protein synthesis and breakdown.

    So as we can see here, relying on one or the other, and debating which is superior is futile in the hopes to gain the most benefits from them. To tip the scale in your favor, you need to increase protein synthesis and slow down muscle breakdown. You would be a fool to write one off.

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Don't Take It All At Once

blender I know what you are thinking, "Why not just mix them together and get the best of both worlds?" Well, I am one step ahead of you. Casein has a unique property, in that ii coagulates in the stomach.12 This causes other proteins to be digested and absorbed much more slowly.

Have you ever tried to run through a vat of tar? It isn't easy by any means. You would be moving very slowly. Casein does the same thing to whey, and other proteins for that matter. Think of it as a sort of binding gel.

This simple little fact would nullify the biggest and most important attribute of whey. That is its ability to flood your system quickly with amino acid and stimulate protein synthesis.

Now before you ask, let me stop you - I already know what you are thinking. Perhaps it would be best to just slam whey protein drinks all day to keep your system swimming in amino acids, right? Wrong! It may seem counter-intuitive, but it would not keep protein synthesis rates up.2

Just having constantly high levels of amino acids or merely having a positive protein balance doesn't stimulate protein synthesis2,5,11 and doesn't lead to increases in muscle mass.18

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Then what does, you ask? All evidence points to the same thing time and time again. It is the acute and large increase in the amount of amino acids in the blood that causes protein synthesis rates to increase.2,5,11,20,15,13 If you were to tap a vein with an IV to crank blood levels of amino acids up and keep them there, we would see a dramatic increase in protein synthesis as well as a decrease in protein breakdown.11,2

However, right around two hours, synthesis rates will level off and return to normal despite the abnormally high levels of amino acids.2 What is even more interesting is that even if amino acid levels are already very high and protein synthesis is dropping, I can consume more amino acids and further stimulate an increase in synthesis rates.11


"How To" Manual

So, here is the 'take home' message. It is not about just shoveling down 4,000 calories7 or X-amount of protein to keep your blood saturated with amino acids at all times.

It is the about presenting your body with sudden change and increase of amino acids that stimulates protein synthesis rates.2,5,11,20,15,13,9 This is why it is important to understand the differences between the various types of protein supplements.

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When products start touting how much of a certain amino acid they have added or that they have a better amino acid profile, just skip it. It doesn't matter.5 The amino acid profile becomes important when you are comparing different protein sources. And since both casein and whey are derived from milk, they have essentially the same amino acid profile.

You should be concerned with the main source of protein so that you know what that product will do for you. Will it stimulate protein synthesis? Or will it slow protein breakdown?


Finding The Middle Ground

Make no mistake about it, a high protein diet is a requirement for packing on high-quality muscle mass.1,9,13,15,16,19 But you need to find that middle ground.

As we have covered, if you consume so much that you have chronically high levels of amino acids in your blood, much of the protein you consume will go straight down the toilet. Literally!1,2,5,11,17 But don't let people sell you on the myth that your body can only handle so many grams of protein at one time.

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Firstly, this is a very vague statement. What is meant by "handle" or "at one time"? About 50% of what you consume is incorporated into muscle tissue one way or another. 20% is incorporated into other body proteins and the remaining is oxidized.11,5,1

A large majority of the 30% is a class of amino acids called "non-essential amino acids".17 And this breakdown of metabolic fates is true for just about any protein intake "at any one time".

intravenous drip On the other hand, if you play it too safe, you will short circuit the muscle building mechanisms and the balance will shift towards muscle breakdown.4,11,18,16,19

So, the next time that someone tells you that they won't be happy until they can walk around with an IV drip of amino acids tapped into their arm, you can tell them they are just wasting their time. Not only that, but you will understand why!


Precision Protein Supplementation

Alright, so we now have all of this information swimming around in our heads. What do we do with it? Let's put it together into a plan.

We know that we need to increase protein synthesis and reduce protein breakdown, right? We know that whey is the most effective product to stimulate protein synthesis, and we know that casein is the most effective product to reduce protein breakdown. We can't use them together, however, because casein will nullify whey's primary mode of action.

However, we have one more weapon in the arsenal that we can use. And that is our good ol' friend, food. In general, whole food proteins are digested very slowly. That means they will cause a mild and constant stream of amino acids into the blood, much like casein. However, most whole foods do not coagulate in the stomach and do not slow the digestion of other proteins.

So, the first step in the plan is to forget what you think you know about supplement timing. It is okay to consume whey protein at times during the day other than before or after a workout. And honestly, you should.

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     Step #1: Whey After Food.

    Consume a whey protein drink shortly after a whole food meal.

    By doing so, you will have created an environment very conducive to muscle growth. By consuming that whole food meal, you will have suppressed the rate of muscle breakdown. Firstly, by starting a slow cascade of amino acids through your system.

    Secondly, provided your meal had some kind of carbohydrates, you will have stimulated the release of insulin which, in itself, can slow the rate of muscle breakdown.11,5,3,8,14

    Insulin is also the hormone that governs protein synthesis rate. By elevating the release of insulin before the consumption of a whey protein drink, you have effectively set the stage for a serious anabolic reaction.14,10,11

    There is a slight delay from the time you digest carbohydrates and the time that insulin levels peak. Because of the fact that whey is absorbed so quickly, it is possible that the peaks between amino acids and insulin will not coincide, resulting in a less-than-optimal response.11,14

    Once the whey protein has been completely assimilated, amino acid levels will drop. However, they will not return to normal, because the "Amino Acid Cascade" that you stared with the whole food meal is still streaming. It's a beautiful sight, isn't it? This little step has effectively stimulated protein synthesis as well as slowing protein breakdown.

      To View Our Whey Protein Recommendations, Click Here.

     Step #2: Casein Within 3 Hours.

    Consume a casein-based meal within the next 3 hours.

    That means before three hours have elapsed - two hours would be an even safer bet. We want the levels of amino acids in our blood to drop a bit so we can create a dramatic increase again.

    The degree of protein synthesis is directly related to the degree of change in the levels of amino acids. By consuming a casein-based meal here we will allow for that drop while keeping amino acid levels above normal. This keeps the rate of protein breakdown to a minimum. Do you feel the scales tipping yet?

    Examples of good casein-based protein products are Molecular Sustained Protein and Xtreme Formulations Ultra Peptide.

      To View Our Casein Protein Recommendations, Click Here.

     Step #3: Lather, Rinse, Repeat.

    Repeat! That's all there is to it.

    Alternate between a whole food meal with a whey protein chaser, and follow that up with a casein-based meal. Now, I know this sounds expensive so you can modify it. You may want to reduce the size of the whey protein drink. But remember, the degree of protein synthesis is dependant on the degree of the increase in the levels of amino acids in the blood.2,5,11,20,15,13

    Fist full of money So take caution when you are feeling cheap. It would not make sense to cut your servings and not have a very good response from it. You could also have just a whole food meal instead of a casein-based one. You would essentially get the same effect.

    However, many meal replacement products on the market today have a far better nutritional profile than anyone of us could every pull off in the kitchen. I highly recommend two a day, making sure to have one just prior to bed.


Conclusion

Well there you have it - a three pronged attack: Precision Protein Supplementation. You now have the tools and knowledge to strategically create an environment that is highly conducive to not only increasing lean muscle mass, but preserving it as well. You will be surprised how effective this little strategy is during times of low-calorie dieting.

So, in summary, casein is a "slow" protein that is classified as anti-catabolic. That means that it prevent excessive protein breakdown. Whey protein is a "fast" protein that is classified as anabolic - meaning that it stimulates protein synthesis, but does not inhibit catabolism.5,12,2

What Do Anabolic And Catabolic Mean?
Anabolic refers to the metabolic process that is characterized by molecular growth, such as the increase of muscle mass. Thus, it means "muscle-building" in most common bodybuilding contexts.

Catabolic, therefore, refers to the metabolic process that is characterized by molecular breakdown and energy release, such as the decrease of muscle mass (atrophy).

We can't do both at the same time, but we can mimic the effect by manipulating our dietary intake. And finally, it is the rapid increase of amino acids that results in increases in protein synthesis.

Hopefully I have shed some light on the subject. There is no "best" type of protein, only a best approach. I'll never try to sway you one way or the other, I will only present you with the facts.

Don't let anyone tell you anything different. If they are convinced that there is a "best", they are only joking themselves. Just smile, nod, and realize that you are bigger than that guy!

References

  1. Anders H. Forslund, Leif Hamraeus, Roger M. Olsson, Antoine E. El-Khoury, Young-Ming Yu, and Vernon R. Young (1998). The 24-h whole body lecine and urea kinetics at normal and high protein intakes with exercise in healthy adults. Am. J. Physiol Endocrinol. Metab. 38, E310-E320.
  2. Bohe J., F. AiliLow, R.R. Wolfe, and M.J. Renne (2001). Latency and duration of stimulation of human muscle protein synthesis during continuous infusion of amino acids. J. Physiol, 532, 2, 575-579.
  3. Bos C., Metges C. C., Gaudichon C., Petzke K. J., Pueyo M. E., Morens C., Everwand J., Benamouzig R., and Tome D (2003). Postprandial Kinetics of Dietary Amino Acids Are the Main Determinant of Their Metabolism after Soy or Milk Protein Ingestion in Humans; J. Nutr.,133,5, 1308-1315.
  4. Bryner R.W., Ullrich I, Saunders J., Donley D., Hornsby G., Kolar M., Yeater R (1999). Effects of resistance vs. aerobic training combined with an 800 calorie liquid diet on lean body mass and resting metabolic rate, J. Am. Coll. Nutri, 18,1, 115-121.
  5. Dangin M., Biorie Y., Rodenas-Garcia C., Gachon P., Fauquant J., Callier P., Ballevre O., and Beaufrere B (2001). The digestion rate of protein is an indipendant regulating factor of postprandial protein retention, Am. J. Physiol. Endocrinol. Metab, 280 E340-E348.
  6. Dolezal Brett A., and Jeffery A. Potteiger (1998). Concurrent resistance and endurance training influence basal metabolic rat in nondieting individuals. J. Appl. Physiol; 85, 2. 695-700.
  7. El-Khoury E., A. Forslund, R. Olsson, S. Branth, A. Sjodin, A. Andersson, A. Atkinson, A. Selvaraj, L. Hambraeus and V. R. Young (1997). Moderate exercise at energy balance does not affect 24-h leucine oxidation or nitrogen retention in healthy men, 273, E394-E407.
  8. Gaudichon C., Mahe S., Benamouzig R., Luengo C., Fouillet H., Dar S., Oycke M., Rerriere R., Rautureau J, and Tome D. (1999). Net Postprandial utilization of [15N]-Labeled milk protein nitrogen is influenced by diet composition in humans., J. Nutr.,129, 890-895.
  9. Kobayashi H., E. Borsheim, T. G. Anthony, D. L. Traber, J. Badalamenti, S. R. Kimball, L. S. Jefferson, and R. R. Wolfe (2003). Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B; Am J Physiol Endocrinol Metab. 284,3, E488-498.
  10. Kreider RB, et al. (1996). Effects of ingesting supplements designed to promote lean tissue accretion. Int. J.Sport Nutrition 6,3, 234-236.
  11. Miller S. L., Tipton K. K., Chinkes D. L., Wolfe S.E., and Wolfe R.R. (2003). Independent and combined effects of amino acids and glucose after resistance exercise. Med Sci. Sports. Exerc., 35, 3, 449-455.
  12. Mahe R., Roos N., Benamouzig R., Davin L., Luengo C., Ganon L.,Gausseres N., Rautureau J. and Tome D (1996). Gastrojejunal kinetics and the digestion of [15N]beta-lactoglobulin and casein in humans: the influence of the nature and quantity of the protein. Am J. Clin Nutr, 63, 546-552.
  13. Pannemans DL, D Halliday and KR Westerterp (1995). Whole-body protein turnover in elderly men and women: responses to two protein intakes J. Am. Clin. Nutr, 61, 33-38.
  14. Rasmussen B. B., Tipton K.D., Miller S. L., Wolf S.E., and Wolfe R.R (2000). An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise J. App. Physiol, 88, 386-392.
  15. Robinson SM, C Jaccard, C Persaud, AA Jackson, E Jequier and Y Schutz (1990). Protein turnover and thermogenesis in response to high-protein and high-carbohydrate feeding in men Am. J. Clin. Nutr, 52, 72-80.
  16. Thureen P.J., Melara D., Fennessey P.V., and Hay,Jr. W.W. (2003). Effect of low versus high amino acid intake on very low birth weight infants in the early neonatal period, Pediatric Res, 53 24-32.
  17. Tipton, K.D., B.E. Gurkin, S. Matin, and R.R. Wolfe (1999). Nonessential amino acids are not necessary to stimulate net muscle protein synthesis in helthy volunteers. J. Nutr Biochem., 10, 89-95.
  18. Wolfe R.R. (2001). Control of muscle protein breakdown: Effects of activity and nutritional states. Int. J. Sport Nutr. And Exerc Metab., 11, S164-S169.
  19. Williams S. B., G. Bartsch, N. Muurahainen, G. Collins, S. S. Raghavan, and D. Wheeler (2003). Protein Intake Is Positively Associated with Body Cell Mass in Weight-Stable HIV-Infected Men J. Nutr., 133,4 1143-1146.
  20. Yoshizawa F. Takashi N., Nishizawa N., and Ryuhei Funabiki (1997). Protein synthesis and degradation change rapidly in response to food intake in muscle of food-derived mice, J. Nutr. 127, 1156-1159.

Should I Take Casein Or Whey Protein?
eric@muscleoverload.com

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I'm confused..

The way I understand it is that protein, among other nutrients can only be absorbed in specific quantities. Your body can only absorb so many vitamins, so much protein and so on because the liver has to work through it. I also understand that the bi-product of the metabolizing of protein is ammonia; this is why it is important to hydrate because water helps to take care of the ammonia that without water the liver would have a hell of a time breaking down. So much so that you can actually get ammonia poisoning from ingesting too much protein without breaks to metabolize and not properly hydrating.

I guess what I'm trying to drive at here is that I've been told a protein source 20-30g in size every 2-2.5 hours with proper hydration in between is an appropriate method to promote near constant protein synthesis, allowing for mass gains. Now, has it worked for me? No, my body type allows for a very difficult weight gaining endeavor and frankly I don't understand why I'm not gaining.

I have (three) 20-30g whey shakes daily, including my post workout shake, and this is on training days and non-training days. Along with this, I have 3-4 whole meals a day, each with a source of protein (20-30g), and a large source of carbohydrates. I end the day with a Casein shake before bed. All of these "meals" are 2-2.5 hours apart almost down to the minute. Help! lol.

Oct 29, 2013 9:22am | report
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