Ready Player One provides you with a variety of brain-boosting nootropic ingredients such as Dimethylaminoethanol (DMAE Bitartrate), L-Glutamine, L-Tyrosine, and GABA to help you improve your focus, learning, and memory. It also contains cognitive enhancing extracts including Green Tea, Bacopa, Bilberry Fruit, Grape Seed Extract, Olive Leaf, Cinnamon Bark, and Licorice Root. Finally, you also get Vitamins A, B1, B2, B3, B5, B6, C, D, E as well as minerals such as Calcium, Iron, Magnesium, Zinc, Selenium, Copper, Manganese, Chromium, Potassium, Molybdenum, and Choline to help complete your nutritional profile.  

Humans are limited in their ability to synthesize choline and therefore acquire most of it through their diet (1). DMAE is a precursor to choline. This allows the brain to optimize the production of acetylcholine, which is the primary neurotransmitter involved in learning and memory (2). DMAE also has strong inflammation-supporting properties and may help fight against age-related neuroinflammation (3).  



Glutamine is an essential cerebral metabolite that is responsible for several brain processes, such as energy metabolism and neurotransmitter recycling (4). Tyrosine is a precursor of dopamine and norepinephrine and supplementation can counteract a decline in neurotransmitter function and cognitive performance (5) GABA or gamma-aminobutyric acid receptors are responsible for stress support and sleep (6)(7). GABA supplementation has also shown promising results in improving cognitive flexibility and contextual learning (8).

Green Tea has polyphenols which have powerful inflammatory support and nootropic effects (9). A meta-analysis of 21 clinical studies reported that green tea extract could aid stress support, improve attention, working memory, and memory recall (10).

Bacopa monnieri is a nootropic herb used in traditional Ayurvedic medicine for cognitive enhancement. The neurological properties of Bacopa are likely due to the presence of a group of saponins collectively referred to as bacosides (11). Clinical studies have demonstrated improvements in verbal learning, short-term memory acquisition, and stress support (12)(13). A 2014 meta-analysis of randomized controlled trials reported that Bacopa has the potential to improve cognition (14).

Bilberry fruit or Vaccinium myrtillus is one of the richest natural sources of anthocyanins which are believed to have vasodilatory and inflammation-supporting effects that can help preserve cognition and neuromotor function (15). In animal studies, bilberry is reported to promote short-term memory, vision, and control of sensory input (16).

Grape seed contains several flavonoids, polyphenols, which can exert potent antioxidant and inflammation-supporting effects that could help with oxidative stress and brain health (17). Cinnamon bark has been shown to have bioactive compounds that can influence brain function and may be useful for promoting cognitive function (18). Licorice Root may possess therapeutic agents that fight against cognitive impairment by ameliorating inflammation-induced cognitive dysfunction by promoting a healthy inflammatory response (19).

Remix Nutrition: Ready Player One can help get you in the zone for any mental challenges. 

References: 



  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252906/ 
  2. https://pubmed.ncbi.nlm.nih.gov/22300295/ 
  3. https://pubmed.ncbi.nlm.nih.gov/37127686/ 
  4. https://pubmed.ncbi.nlm.nih.gov/36322369/ 
  5. https://pubmed.ncbi.nlm.nih.gov/26424423/ 
  6. https://pubmed.ncbi.nlm.nih.gov/34830337/ 
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527439/ 
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122390/ 
  9. https://pubmed.ncbi.nlm.nih.gov/34203004/ 
  10. https://pubmed.ncbi.nlm.nih.gov/28899506/ 
  11. https://www.ncbi.nlm.nih.gov/books/NBK589635/ 
  12. https://pubmed.ncbi.nlm.nih.gov/31126578/ 
  13. https://pubmed.ncbi.nlm.nih.gov/35612544/ 
  14. https://pubmed.ncbi.nlm.nih.gov/24252493/ 
  15. https://www.ncbi.nlm.nih.gov/books/NBK92770/ 
  16. https://pubmed.ncbi.nlm.nih.gov/17533652/ 
  17. https://pubmed.ncbi.nlm.nih.gov/35343876/ 
  18. https://pubmed.ncbi.nlm.nih.gov/36652384/ 
  19. https://pubmed.ncbi.nlm.nih.gov/29854324/