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Clayton's Health Facts: Sesamin.

Clayton South, SPN (ISSA), is a recognized expert in the bodybuilding / fitness industry with over 150 bodybuilding, fitness and nutrition publications to his credit.

What Is It?
And Where Does It Come From?

Sesamin is a lipid and a special fiber known as a lignin (phytoestrogen). Sesamin is present in sesame oil and is extracted from sesame oil after sesame oil has been removed from the mature open seeds of the sesame plant (Sesamun indicum).

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Sesame plants are grown and harvested in India and most parts of Asia. Sesame plant seeds are brown, red and black, or ivory in appearance.

The sesame plant has long been used throughout the world as a food ingredient and as a medicinal plant in traditional medicine systems. The use of sesame seeds for culinary and medicinal purposes date back more than 3,000 years.

What Does It Do?
And What Scientific Studies Give Evidence To Support This?

As a food ingredient, sesamin enhances the flavor and texture of food dishes.

When used as a dietary supplement ingredient, sesamin increase energy levels, supports healthy hormone function, supports healthy cholesterol profile and optimal liver and kidney health.

As a lipid, sesamin is a dense energy source that boosts mood and provides more than twice the amount of energy of protein and carbohydrates. Not only that, but sesamin is used by the endocrine system to maximize anabolic hormone production.

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Anabolic hormones are responsible for energy increases and increases in protein synthesis, strength gains and muscle tissue formation. By stimulating the endocrine system, sesamin may cause rapid strength and muscle gains, and speed exercise recovery.

What Does Anabolic Mean?
Anabolic refers to the metabolic process that is characterized by molecular growth, such as the increase of muscle mass. Thus, it means "muscle-building" in most common bodybuilding contexts.

Aside from building muscle by boosting testosterone levels, sesamin causes rapid fat loss by reducing cravings, promoting feelings of fullness, preventing fat storage, and by stimulating PPAR (Peroxisome Proliferator-Activator Receptor Alpha) receptors.

PPAR receptors - located throughout the body, but concentrated primarily in heart, kidney and liver tissues - play a critical role in fat storage and fat metabolism.

Not only can sesamin prevent the storage of body fat in the first place, but PPAR receptor stimulation can lead to systemic and localized fat loss of already existing body fat. By stimulating PPAR receptors, sesamin trains your body to be a better fat burning machine!1

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Best of all, sesamin is stimulant-free, so there's no "rebound" weight gain or water retention once you stop using sesamin. The same can't be said for stimulant-based fat loss products like ephedrine.

In addition to the benefits already listed, sesamin protects immune system health by cleaning the body of toxins, and it protects the liver and kidneys by preventing liver fat storage, and increasing the bioavailability of the antioxidant Vitamin E.2

Sesamin also impacts blood cholesterol profiles, and can lower LDL cholesterol (low density lipoprotein - the so-called "bad" cholesterol), while raising HDL cholesterol (high density lipoprotein - the so-called "good" cholesterol). This can lead to reductions in blood pressure, and can promote heart health by reducing the amount of work done by the heart to circulate blood.

Who May Benefit From Using
This Dietary Supplement?

Sesamin is a diverse supplement ingredient. Healthy adults from all populations may benefit from using sesamin as a dietary supplement ingredient.

Bodybuilders and athletes who want to build muscle, burn fat, improve performance and speed recovery may find sesamin effective because of its apparent ability to boost testosterone levels and positively impact the endocrine system.

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People who want to lose body fat may also benefit from using sesamin because it promotes feelings of fullness, suppresses cravings, and speeds fat loss. Sesamin is especially ideal as a fat loss agent for stimulant sensitive people, because sesamin is a stimulant-free, weight-loss promoting dietary supplement ingredient.

Because PPAR receptors are located in liver tissue, and because sesamin stimulates PPAR receptors, even moderately and extremely overweight and obese persons can benefit from sesamin supplementation. By stimulating PPAR receptors and encouraging fat metabolism, sesamin may help prevent the onset of non-alcoholic fatty liver diseases (NAFLD) steatosis and steatohepatitis (NASH), or lessen the severity of symptoms after onset.

How Much Should Be Taken?
Are There Any Side Effects?

Sesamin dosing ranges have not been established. Use as directed on the product label.

The effects will vary from person to person because of genetic differences. While sesamin is considered safe for use by healthy adults, sesamin allergies have been reported.

Sesamin may be contraindicated with diuretic (water loss pills) medications. As always, consult with your physician prior to using any dietary supplement.


  1. Takashi IDE, Masayo KUSHIRO, Yoko TAKAHASHI, Kazuki SHINOHARA, Nobuhiro FUKUDA and Satoko SIRATO-YASUMOTO. Sesamin, a Sesame Lignan, as a Potent Serum Lipid-Lowering Food Component. JARQ 37 (3), 151-158 (2003).
  2. Tohru Utsunomiya, Sambasiva R Chavali, W William Zhong and R Armour Forse. Effects of sesamin-supplemented dietary fat emulsions on the ex vivo production of lipopolysaccharide-induced prostanoids and tumor necrosis factor alpha in rats. American Journal of Clinical Nutrition, Vol. 72, No. 3, 804-808, September 2000.


The information provided in this publication is for educational and informational purposes only and does not serve as a replacement to care provided by your own personal health care team or physician. The author does not render or provide medical advice, and no individual should make any medical decisions or change their health behavior based on information provided here. Readers are encouraged to confirm the information contained herein with other sources. Readers and consumers should review the information in this publication carefully with their professional health care provider.

The information in this or other publications authored by the writer is not intended to replace medical advice offered by physicians. Reliance on any information provided by the author is solely at your own risk. The author does not recommend or endorse any specific tests, products, medication, procedures, opinions, or other information that may be presented in the publication. The author does not control information, advertisements, content, and articles provided by discussed third-party information suppliers.

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Copyright ©2006 Clayton South, All rights reserved.

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