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What is food intolerance?
Countless numbers of people have food sensitivity and intolerance - often without being aware of it. Effects can range from common digestive system issues due to the body's inability to thoroughly digest food caused by the lack of proper amounts of certain enzymes.
Many food intolerances are confused with food allergies and are caused by elevated levels of histamine in food. These elevated histamine levels can make eating foods, such as pizza, fish, and many other foods a miserable experience. Until now, one of the only options was to avoid these histamine-containing foods.
Histame decreases histamine levels that cause food intolerance by replenishing the body's digestive enzyme Diamine Oxidase (DAO).* This dietary supplement helps regulate histamine levels in the body.*
Food intolerance versus food allergy
It is important to recognize the difference between food intolerance and food allergy. Non-allergenic histamine food intolerance is mostly brought on by foods not processed properly in the intestinal tract.
Food intolerance is a digestive system response to the inability to digest particular ingredients in food that does not involve the immune system. In contrast, a food allergy is an abnormal response to food triggered by the body's immune system.
Reactions to histamine found in foods are not food allergies, though the symptoms can look and feel the same. Furthermore, the severity of the food intolerance symptoms is dependent on the ingested amounts of histamine-rich food.
IMPORTANT: Allergic reactions can cause serious illness and, in some cases, death. If you have a food allergy, it is extremely important that you work with your health care provider to find out what food(s) cause your allergic reactions.
Histamine
A biogenic component often found is processed foods, histamine is an amine (nitrogen) derived from the decarboxylation of the amino acid histidine. In the digestive tract (GI), Diamine Oxidase (DAO) breaks down histamine.* Histamine can mimic the discomforts commonly caused by immune system-based food allergies.
Histamine-rich Foods/Substances
Histamine levels will vary based on the maturation process and the degree of freshness. The longer food is stored or left to mature, the greater its histamine content and the more problematic it can be for individuals with food sensitivities and intolerance.
Fresh meat contains no or very little histamine. However, when meat is processed further, the maturation process results in the accumulation of biogenic amines.
The same is true for fish. Fresh fish contains no or very little histamine. However, fish spoils very easily and this leads to a rapid accumulation of histamine due to bacteria. Further processing, which includes salting, smoke-drying, marinating and preservation, may increase the histamine content.

Examples of foods/substances that may increase histamine levels:
- Alcohol, particularly red wine and champagne. Also white wine and beer.
- Aged, smoked, canned fish and fish sauces. Tuna fish, mackerel, sardines, anchovy, herring, catfish, salmon.
- Pizza
- Smoked and processed meats such as salami, ham, bratwurst and bacon
- Sauerkraut
- Certain vegetables: tomato, spinach, eggplant, avocado, mushrooms and canned vegetables as well as commercially prepared salads
- Certain fruits: strawberries, bananas, papayas, kiwi, pineapple, mango, tangerines, grapefruits, red prunes, pea
- Red wine vinegar, balsamic vinegar
- Soy sauce
- Cheese
- Mustard
- Ketchup
- Sunflower seeds
- Chocolate/cocoa
- Coffee, black tea
- Some fruits: citrus, bananas, strawberries, red prunes, pears, kiwi, raspberries, papaya
- Bread and confectionery made with yeast
- Peanuts, cashews, walnuts
How to use Histame
Hundreds of thousands of Europeans have already been helped with the Diamine Oxidase ingredient in Histame
Already available and sought after throughout Europe, Naturally Vitamins' new dietary ingredient (NDI), the Diamine Oxidase (DAO) enzyme, was acknowledged by the Food and Drug Administration in 2008. This breakthrough achievement offers hope to millions of Americans who may deal with histamine food intolerance.
Histame naturally helps discomforts caused by food intolerance
Histame is one of the first products that regulates histamine levels by replenishing the body's digestive enzyme DAO.*
Histamine is a widely distributed biogenic amine, found in many foods. DAO, the intestinal tract histamine-degrading enzyme, breaks down ingested histamine, thus helping to lower overall histamine levels. A deficiency of DAO can cause an increase in histamine exposure inside the body, which may result in histamine food intolerance including digestive issues. This dietary supplement is suggested to regulate the histamine levels in the body (lower intestine).*
How to take Histame
For optimal results, take 1 to 2 Histame capsules within 15 minutes of consuming histamine-rich foods/substances known to cause food intolerance. Since the main ingredients have been developed to be stomach acid-resistant, you can open the capsules and swallow the ingredients (if preferred to swallowing capsules).
Who should take Histame
This product is for children (5 years and older), teenagers and adults consuming foods rich in histamine. Histame is not intended for those who have immune system-related food allergies.
Warnings and when to ask a health care professional
Histame is not effective with immune system-based food allergies, or with peanut or wheat gluten allergies. Ask a health care professional before use, or if you are taking antihistamines. Keep out of reach of children. Stop use and ask a health care professional if your food intolerance symptoms continue or worsen. Check with your doctor if you are pregnant or nursing.
FAQs
Q: What causes food intolerance?
A: Histamine is an important messenger (mediator) for many allergic and pseudo-allergic reactions. It's produced by the body itself and is contained in various foods like cheese, yogurt, tomatoes, sparkling wine or red wine at different concentrations. Millions of people have digestive issues. Food Intolerance appears when the organism is not able to regulate histamine that is absorbed via food or comes from the body's own cells fast enough.
Q: What's the difference between food allergy and food intolerance?
A: A food allergy is an abnormal response to a food triggered by the body's immune system.
Allergic reactions to food can cause serious illness and, in some cases, death. Therefore, if you have a food allergy, it is extremely important for you to work with your health care provider to find out what food(s) causes your allergic reaction.
Sometimes, a reaction to food is not an allergy at all but another type of reaction called food intolerance, which will often manifest itself as digestive problems, including diarrhea and flatulence.
Food sensitivity or intolerance is more common than food allergy. The immune system does not cause the symptoms of a food intolerance, though these symptoms can look and feel like those of a food allergy.
Q: What can help food intolerance?
A: Diamine Oxidase (DAO) is the body's own absorbing enzyme for histamine. If histamine, due to a deficit of enzymes or repression, is not regulated in a sufficient quantity, the symptoms of histamine intolerance can be released. DAO appears in the whole body, the most important spot is the gut. The activity of DAO determines the speed with which histamine is abolished. In the case of a DAO-deficit or a DAO-repression, histamine gets accumulated, which again causes the symptoms of HIT.
In case of a reduced DAO-activity, histamine-related food needs to be avoided, which due to the various compositions of foods is getting more and more difficult and means a strict and permanent diet.
Q: How do Histame capsules work?
A: Histame is the first product worldwide that regulates histamine levels that can cause food intolerance by replenishing the body's digestive enzyme DAO. The food related deficit of enzymes is thus balanced in a natural way.*
Q: How should Histame capsules be used?
A: For optimal results, take 1 to 2 Histame capsules within 15 minutes of consuming histamine-rich foods/substances known to cause food intolerance. Since the main ingredients have been developed to be stomach acid-resistant, you can open the capsules and swallow the ingredients (if preferred to swallowing capsules).
Q: Who should take Histame?
A: This product is for children (5 years and older), teenagers and adults consuming foods rich in histamine. Histame is not intended for those who have immune system-related food allergies.
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