MHP: DREN

Dren uses an advanced approach to trigger the process of lipolysis for optimal fat burning.* Dren (patent pending compound name Drenbuterol) belongs to a powerful new class of compounds called mesolimbic Beta Agonist Fat Burning Agents.*

Beta-Methoxy Phenylethlyamine (also called Beta-Methoxy PEA) is an exciting new ingredient used exclusively in Dren. Beta-Methox-PEA works in part by promoting noradrenaline (NA) release from sympathetic nerve terminals.* As a sympathomimetic, Beta-Methoxy PEA acts to stimulate the sympathetic nervous system.* It does this by causing pre-synaptic nerve terminals to release norepinephrine, or what is commonly called noradrenaline (NA), into the synaptic space.* It also has the effect of increasing circulating adrenaline, the body's chief beta-2 agonist. Noradrenaline, once released into the synaptic space, interacts with adrenergic receptors on the surface of adipocytes (fat). This initiates a sequence of events within the adipocyte that increases lipolysis (the breaking down of fatty acids) by the enzyme hormone sensitive lipase (HSL). This fat burning effect is dependent on long and steady activation of the receptor by the agonist and is what makes the discovery of Beta-Methoxy PEA so critical and why it may be much more effective than other Beta-PEA Formulas.*

Beta-Methoxy PEA is an effective B-PEA beta-agonist by virtue of its long half-life (stays in the body longer) as well as its affinity to be absorbed in fat tissue and better permeate the blood/brain barrier. In contrast, the half-life of many other Beta-PEA forms is only minutes as the enzyme MAO-B quickly metabolizes them and are less lipophilic which prevents significant concentrations from reaching the brain--- therefore no psychoactive and weight loss effect is achieved. As mentioned earlier, while the inclusion of MAO-inhibitors would seem to work the evidence shows otherwise. Beta-Methoxy PEA does not have to worry about being broken down by MAO-B due to its unique configuration. The beta "Methoxy" moiety on this compound protects it and allows for increased absorption across the blood brain barrier and deep penetration into the fatty tissues of the brain where it interacts with the aDrenergic receptors. This increase in noradrenaline and adrenergic receptors activation increases cAMP levels in fat cells (increasing its breakdown) and muscle cells (increasing protein synthesis). Beta-Methoxy-PEA's unique configuration or moiety is what gives it its long duration of action, its exceptional ability to permeate fat tissue and promote powerful fat burning effects.*

In addition, Beta-Methoxy Phenethylamine's enhanced moiety and ability to better penetrate the blood brain barrier elicits extreme euphoric "feel good" neuro-sensory.* Beta-Methoxy-PEA, is an alkaloid and monoamine, therefore, it is believed to function as a neuromodulator or neurotransmitter and supports psychoactive effects on the body while burning body fat at an unforseen rate.*

While Beta-Methoxy-PEA by itself is a remarkably effective thermogenic, the scientists at MHP wanted to take fat burning to a new level.

In response to Beta-Methoxy-PEA's beta-adrenergic stimulation, negative feedback mechanisms are activated as well. This negative feedback can shutdown lipolysis (fat burning). The alpha 2 receptor, phosphodiesterases and adenosine try to slow down or halt the fat burning process. In the case of Dren, Beta-Methoxy-PEA undergoes these negative feedback mechanisms. Therefore, measures had to be taken to maximize Beta-Methoxy-PEA's actions in the body and minimize these negative feedback mechanisms.

All forms of Beta-PEA are considered non-selective adrenergics through the release of noradrenaline because they don't just activate one type of receptor. Unfortunately, noradrenaline functions as its own negative feedback signal by activating both the beta and alpha adrenergic receptors. As you recall, the stimulation of beta receptors is good as it initiates the fat burning process, but the Alpha 2 receptors actually shut down lipolysis (fat burning). MHP scientists added Yohimbine HCL to the Dren formula to bypass Alpha 2 receptor binding and increases the effectiveness of Dren. Yohimbine HCL is a selective alpha 2 antagonist and can thus short circuit this feedback loop, maximizing noradrenaline levels and the overall fat loss actions of Beta-Methoxy PEA. What we have created is a mechanism of action which is long acting activation on the beta receptor with little to no activity at the alpha receptor.

Most people like caffeine because of its stimulatory and energizing effects. But, caffeine has a much more important role than that in Dren. Stimulation of Beta-adrenergic receptor also means an increase in phosphodiesterase and adenosine activity. Phosphodiesterase (PDE) acts to hydrolyze cAMP into inactive fragments while adenosine inhibits cAMP accumulation halting the stimulation of HSL and the fat burning process. Caffeine possesses the ability to inhibit phosphodiesterases within the cell and has even been surmised to have the ability to prevent some re-uptake of norepinephrine while also acting as an adenosine receptor blocker.* As you can see, caffeine provides important powerful synergies to maximize Dren's fat burning effects.*

The mind is a powerful thing! There is no denying it Beta-Methoxy-PEA is very psycho-active and triggers a euphoric "feel good response". To further enhance Dren neuromodulator activity L-5-Hydroxytryptophan has also been added to the formula. L-5-Hydroxytryptophan is a naturally-occurring amino acid, a precursor to the neurotransmitter serotonin which is a monoamine neurotransmitter with feel good and appetite suppression properties. L-5-Hydroxtryptophan like Beta-Methoxy-PEA also passes through the blood brain barrier into the brain. It's psychoactive action are thought to be derived from its effect on serotonin synthesis in central nervous system tissue. It is believed that a high supply of L-5-Hydroxytryptophan causes the brain's serotonin-producing neurons to increase production leading to increased serotonin release. The serotoninergic system is known to help modulate mood, emotion, sleep and appetite and thus is implicated in the control of numerous behavioral and physiological functions. L-5-Hydroxytryptophan helps to keep serotonin and norepinephrine levels in balance therefore increasing metabolism and fat loss through synergistic actions with other ingredients in Dren. The end result is the promotion of a"feel good" state of euphoria.*

The fact is, Dren belongs to a powerful new class of compounds called mesolimbic beta agonist, which have extremely powerful fat burning and euphoric activity and should be taken with caution.* Dren promotes both metabolic and mesolimbic pathways for thermogenic fat burning and neurotropic "feel good" sensory.* Each Dren capsule provides the maximum 470mg dose of Drenbuterol and should only be taken once daily and should not be used with other stimulants. When take as directed, Dren may help potentiate thermogenic fat burning, increase energy levels, suppress appetite and illicit a state of heightened mental euphoria.*