Jarrow Formulas: SAM-e 400

Jarrow Formulas®stabilized SAM-e 400 provides a full 400 mg elemental SAM-e from 800 mg of SAM-e tosylate disulfate. SAM-e 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.

Contains More of the Active S,S Form

SAM-e (S-Adenosylmethionine) is a chiral molecule and therefore consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive.

Jarrow Formulas® SAM-e is made naturally by microbiological fermentation and then specially processed without solvents to preserve 68-80% (S,S) SAM-e, the highest active level available. SAM-e is an amino acid derivative that has been clinically surmised to benefit brain, joint and liver function.* Found in all living cells, SAM-e is often referred to as “activated” methionine (an essential amino acid) since it is formed by the combining of ATP with methionine. SAM-e has undergone dozens of trials involving thousands of patients. Researchers studying the beneficial effects of SAM-e have identified the following benefits of SAM-e:

Joint Strength* - SAM-e supports the production of healthy connective tissue through transulfuration.* In this process, critical components of connective tissue, including glucosamine and the chondroitin sulfates, are sulfated by SAM-e metabolites.

Brain Metabolism* - SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-dopa, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin).*

Longevity* - Methylation of DNA appears to be important in the suppression of errors in DNA replication. Demethylation of DNA is considered a contributor to the aging process. Proper methylation through substances such as SAM-e positively influences longevity.*

Liver* - SAM-e metabolism supports the synthesis of glutathione (GSH) and glutathionedependent enzymes (glutathione peroxidase and glutathione-S-transferase), which are substances important for liver function.*