Doctor's Best Double Strength SAMe 400

S-Adenosyl Methionine (SAM-e) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. Methylation occurs billions of times daily in the many organs of the body. SAM-e is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAM-e is also required for the biosynthesis of critical neurotransmitters and hormones. SAM-e is the methyl donor that catalyzes the production of epinephrine, melatonin, glutathione and the amino acids cysteine and taurine. SAM-e is also known to upregulate the production of critical membrane phospholipids including phosphatidylcholine. SAM-e is also a sulfur donor and, for this reason, is critical for the formation of sulfur-containing proteoglycans in joint connective tissue.

During the manufacture of SAM-e, two forms are produced known as the S,S and the R,S isomers. The S,S isomer is the biologically active form in the human body, whereas the R,S form is considered to be inactive. Best SAM-e 400 utilizes Italian SAM-e to yield the highest available percentage of the active pure S,S form on the market. Best SAM-e 400 contains an average of nearly 74% of the active S,S form. Other SAM-e products contain as little as only 50% of the active form. A higher content of the active form yields a more potent product.

The molecule SAM-e itself is highly unstable. It will degrade quickly in conditions of heat, light and moisture. To increase its stability, it must be formed into a salt. It is important to note that SAM-e used for dietary supplements exists in a number of salt forms. Best SAM-e utilizes the SAM-e tosylate disulfate salt form. This salt has been the most extensively utilized form in clinical trials of SAM-e.

Because of the unstable nature of pure SAM-e it is also highly susceptible to degradation in an acidic environment like the stomach. To be utilized effectively, it must pass through the stomach for absorption in the small intestine. For this reason, only enteric-coated formulas should be used. Best SAM-e tablets are enteric-coated to maximize the utilization and benefit of the SAM-e by the body.

SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters. SAMe may also upregulate the production of phosphatidlycholine, supporting cognitive function.

As a sulfur donor to connective tissue, SAM-e plays a major role in protecting the integrity of cartilage tissue. An in vitro trial assessed the actions of SAM-e in cultured human articular chondrocytes. At a concentration of 10 micrograms/ml, proteoglycan synthesis and sulfate residue incorporation in chondrocytes was shown to be 60% higher than control levels. Based on these results, it was shown that SAM-e has a positive influence on the growth and health of cartilaginous connective tissue.

In a double-blind trial with 734 individuals with compromised joint health. SAM-e given orally at a dose of 1200 mg daily for 30 days was shown to significantly promote joint comfort compared to placebo, with a high level of tolerability and low incidence of side effects. The researchers concluded that SAM-e is a highly effective supplement for enhancing joint comfort.

SAM-e supplementation can have profound benefits on liver function. These benefits center around its function as the major methyl donor in the liver, as well as its lipotropic activity. SAM-e also enhances the production of the antioxidant glutathione.