BioSynergy Alpha-GPC

1. Increases human Growth Hormone (hGH)
   Increases in endogenous human Growth Hormone (hGH) secretion by the anterior pituitary in conjunction with Growth Hormone Releasing Hormone (GHRH); that is, both Alpha-GPC and GHRH act concertedly to stimulate the release of hGH, naturally;

2. Improved mental focus and stimulation of cognitive function
   Stimulation of the enzymatic synthesis of phosphatidylcholine (PC) in nerves, muscle cells and all cell membranes, counteracting the age-related decrease in phospholipid (PC) biosynthesis; thus, Alpha-GPC contributes directly to improved mental focus and stimulation of cognitive function;

3. More strength from work-outs and training programs
   Acts as a precursor of acetylcholine (ACh); thus, Alpha-GPC activates cholinergic transmission which permits the development of more strength from work-outs and training programs, plus reducing levels of somatostatin in the hypothalamic-pituitary axis;

4. Improved lipotrophic functions in the liver
   Elevations in blood and tissue levels of the essential nutrient, choline, which supports improved lipotrophic functions (methyl group transferases) in the liver. Alpha-GPC also acts synergistically with the body's store (and/or supplementation) of S-adenosyl-L-methionine (SAM or SAMe) and folic acid, vitamin B12 and vitamin B6 to facilitate methyl group transfers in the brain and liver;

5. Improved balanced and coordination
   Produces improved balanced and coordination when combined with 'skill set' practice and training as a result of normalized nerve transmission in the brain, and in cardiac, skeletal and smooth muscles.

L-Alpha Glycerylphosphorylcholine (Alpha-GPC) sometimes called GPC (glycerophosphocholine) is a naturally occurring phospholipid precursor and metabolite derived from soy lecithin.

Alpha-GPC Information:

Alpha-GPC has been shown to potentiate the effects of growth hormone releasing hormone (GHRH) and increase human growth hormone (hGH) secretion in young and elderly individuals.

Alpha-GPC's cognitive and growth hormone (GH) enhancing effects appear to be primarily the result of stimulation of the cholinergic neurotransmitter system; however, other biochemically-related modulations and neurotransmitter systems have been implicated.

Ageing and prolonged stress - including athletic endeavors like marathons or 'ironman/ironwoman' events are associated with decreased hormone production, especially reduced secretion of human Growth Hormone (hGH) from the anterior pituitary. These life events are also associated with lower levels of free choline in the blood and tissues. Concomitantly, both quality of life and lifespan decrease, sexual desire and potency diminish, muscles loose both protein (mass) and tone, and body fat levels increase.

In clinical situations, significantly reduced secretion of hGH is associated with short stature, generalized muscle wasting, undesirable mood and affect changes, abnormal sleep patterns, loss of energy and stamina, and decreased cellular and humoral (antibody) immune functions.

Fate and distribution studies demonstrate that orally administered Alpha-GPC is absorbed quickly from the gastrointestinal tract and is transported in the blood to all cells and tissues, especially the brain. Alpha-GPC crosses the 'blood-brain' barrier and acts as a central nervous system (CNS) cholinergic stimulant while it simultaneously increases the GHRH-stimulated secretion of hGH by the somatotrophe cells in the anterior pituitary. The current understanding of Alpha-GPC's actions in the brain is that it increases hGH secretion in the pituitary by two (2) separate but interacting neuro-endocrine mechanisms; these are:

1. Modulatory - increasing cholinergic tone lending to decreased levels of somatostatin (produced by the hypothalamus), as a result of the administration of Alpha-GPC;

2. Regulatory - stimulation of hGH synthesis resulting from 'up regulation' of Growth Hormone Releasing Hormone/Factor (GHRH/GHRF) in conjunction with receptor-linked stimulation of the adenylate cyclase (cAMP)-Protein kinase C (PKC)-inositol triphosphate (IP3) intracellular control mechanisms regulating hGH synthesis at the genomic level and its subsequent secretion by the anterior pituitary.

Alpha-GPC has been administered to over three thousand (3,000) patients and volunteers in clinical trials and studies that have been published in the peer-reviewed literature. Minor, transient side effects have been reported to occur at a one percent (1%) frequency; these side effects, for orally administered Alpha-GPC, included diarrhea, dizziness, gastralgis, heartburn, insomnia, restlessness and skin rashes, which resolved when the amount of Alpha-GPC administered was either decreased or eliminated.

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