AST: Myo-D

The quality and quantity of muscle that each of us possess is essentially controlled by protein turnover; a remodeling process that involves the continuous synthesis (anabolism) and breakdown (catabolism) of muscle protein. A gain in muscle mass can only occur via a reduction in the rate at which protein is broken down or an increase in the rate of protein synthesis. However, intense exercise causes a dramatic increase in protein turnover; both synthesis and breakdown accelerate at equal rates. The result is a negative protein balance and zero muscle gains from training. Myo-D's unique formulation is suggested in research to reduce muscle breakdown and stimulate an increase in protein synthesis.* Myo-D promotes muscle gains during intense training by enhancing not one, but the two key processes that are essential to gaining muscle mass.*

Reduce muscle breakdown!*

Myo-D contains a unique 5:1 ratio of EPA:DHA which means a potent dose of bioactive EPA. EPA (eicosapentaenoic acid) is the naturally occurring compound suggested in research to block excessive muscle breakdown by reducing the activity of the major biochemical pathway that results in the destruction of muscle protein and loss of muscle mass.* In clinical studies, EPA is surmised to work at the molecular level and block muscle protein catabolism by reducing the activity of the ATP-ubiquitin-proteasome proteolytic pathway, the major pathway of protein catabolism in muscle.*

The capacity of EPA to block excessive muscle protein breakdown is powerful.* If you're dieting to shed body fat, Myo-D could be you're best ally.* Regular use will help you keep your hard earned muscle during dieting and contest preparation.*

Stimulate muscle protein synthesis!*

A high stimulation of muscle protein synthesis is essential to gaining muscle mass, but it also underlines rapid recovery. Myo-D also contains a precision blend of the most potent amino acids suggested in research to activate protein synthesis within muscle.* Therefore, every serving of Myo-D helps to enhance recovery and gains in muscle mass gains via two vital processes.* Firstly, Myo-D's ultra-high concentration of bioactive EPA blocks excessive protein breakdown.* Secondly, Myo-D provides a high dose of the amino acids that directly activate muscle protein synthesis.*

In research, the formulation within Myo-D is suggested to promote a greater anabolic effect than regular EPA alone or EPA combined with protein.*10 Myo-D is scientifically formulated to reduce muscle breakdown and stimulate an increase in protein synthesis.*

Improve insulin metabolism, enhance fat loss!

The cornerstone of building a lean, healthy, physique is efficient insulin metabolism. Insulin is the hormone essential to nutrient transport into cells. Therefore, a dietary compound that can support insulin metabolism offers a huge advantage for anyone attempting to shed fat or build a lean physique. The high dose of EPA in Myo-D is sugested to promote an insulin-sensitizing effect in tissue, even in healthy people.* That means more calories are directed towards lean tissue for recovery and growth while less calories are stores as body fat.*

EPA is also known to enhance fat metabolism during exercise.* Regular supplementation with EPA appears to increase fat utilization during exercise.* Therefore, Myo-D's 5:1 ratio of EPA provides an ultra-high dose that promotes efficient insulin metabolism and greater fat utilization during exercise.* Myo-D promotes a high rate of muscle anabolism by minimizing protein breakdown and stimulating protein synthesis.* Regular use of Myo-D will also help support insulin metabolism and promote better fat loss during exercise training.*

Product Highlights:

• Stimulate Protein Synthesis*
• Reduce Protein Breakdown*
• Reduce Body Fat*
• Increase Lean Muscle Mass*

References:

1. Barber MD; Fearon KC; Tisdale MJ; McMillan DC; Ross JA. Effect of a fish oil-enriched nutritional supplement on metabolic mediators in patients with ... Nutr ... 40; 118-24, 2001.
2. Whitehouse AS, Tisdale MJ. Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation. Biochem Biophys Res Commun 285; 598-602, 2001.
3. Barber MD. ... cachexia and its treatment with fish-oil-enriched nutritional supplementation. Nutrition 2001;17:751-755.
4. Whitehouse AS, Smith HJ, Drake JL, Tisdale MJ. Mechanism of attenuation of skeletal muscle protein catabolism in ... cachexia by eicosapentaenoic acid. ... Res 2001;61:3604-3609.
5. Stephens CB. Fish Oil and ... Nutrition Reviews 62 (12);486-489, 2004.
6. Bradshaw RA, Brickley WN, Walker KW. N-terminal processing: the methionine aminopeptidase and N-alpha-acetyl transferase families. Trends Biochem Sci 23; 263,1998.
7. Tesseraud S, Bigot K, Toovis M Amino acid availability regulates S6K1 and protein synthesis in avian insulin-insensitive QMT myoblasts. FEBS Lett 540; 176-181, 2003.
8. Vissers YLJ, von Meyenfeldt MF, Deutz MEP. Arginine production in intestine, liver, muscle and kidney is reduced in tumour-bearing mice undergoing surgery. Eur J Gastroenterol Hepatol 14;A59-A64., 2002.
9. Smith HJ, NA Greenberg and MJ Tisdale. Effect of eicosapentaenoic acid, protein and amino acids on protein synthesis and degradation in skeletal muscle of cachectic mice. British Journal of ... 91; 408-412, 2004.
10. Delarue J, Chang-Hong L, Richard C, Charlotte C, Brigitte S. Interaction of fish oil and a glucocorticoid on metabolic responses to an oral glucose load in healthy human subjects. Br J Nutr. 2006 Feb;95(2):267-72.
11. Hufman DM, Michaelson JL, Thomas TR. Chronic supplementation with fish oil increases fat oxidation during exercise in young men. JEPonline. 7(1):48-56, 2004.
12. Kimura Y, Sumiyoshi M. ... and antimetastatic actions of eicosapentaenoic acid ethylester and its by-products formed during accelerated stability testing. ... Sci. 96(7):441-50, 2005.
13. A Nordoy, L Barstad, WE Connor, and L Hatcher. Absorption of the n-3 eicosapentaenoic and docosahexaenoic acids as ethyl esters and triglycerides by humans. Am. J. Clinical Nutrition, 53: 1185, 1190, 1991.
14. Tremoli E, P Maderna, F Marangoni, S Colli, S Eligini, I Catalano, MT Angeli, F Pazzucconi, G Gianfranceschi, and G Davi. Prolonged inhibition of platelet aggregation after n-3 fatty acid ethyl ester ingestion by healthy volunteers. Am. J. Clinical Nutrition, 61: 607 613, 1995.
15. Grimsgaard, KH Bonaa, JB Hansen, and A Nordoy. Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids. Am. J. Clinical Nutrition, 66: 649 659, 1997.