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Applied Nutriceuticals RPM

Applied Nutriceuticals: RPM

Intense Pre-Workout Capsule For Increased Pump*

Explosive Energy, Drive, And Focus And Increased Muscle Strength And Hardness*






What is RPM and What Does it Do?

RPM® is a trend-setter, an innovative product that has been imitated but never duplicated. RPM® is "THE ORIGINAL" anabolic pre-workout in a capsule, and the first formulation to use a high-dose of Icariin to support strength increase along with mind-blowing pumps.* When you want to take your training to the next level but conventional powdered pre-workouts are just not doing it, RPM® delivers rapid results, yielding intense energy and focus within 45 minutes, along with alpha-male aggression to help you power through your workouts.* The synergistic formulation provides both instant and cumulative effects, so whether you are in the gym, on the track or doing what you do to perfect your body RPM® delivers!*

The Basics of RPM

  • Supports N.O. related vasodilation*
  • Promotes a healthy testosterone/cortisol ratio*
  • Promotes blood flow to skeletal muscle*
  • Stimulates ion transport*
  • Improves vascularity*
  • Enhances dopamine/serotonin ratio*
  • Supports energy with no jitters*
  • Promotes mental focus*
  • Measureable strength increases*
  • Unparalleled pumps*
  • Thermogenic fat metabolism*
  • Muscle strength and hardness*

What Makes RPM the Most Effective
PRE-WORKOUT we’ve ever made?

A combination of carefully selected ingredients which when combined produce amazing results like no other pre-workout before it.

L-Arginine Base

L-Arginine is an amino acid that is necessary for cell division, ammonia displacement, hormone release, and immune function.* Most importantly, L-Arginine is necessary for the production of nitric oxide. Nitric oxide is derived from arginine and oxygen through a process called nitric oxide synthase, and exerts its effects on tissue through cGMP. The inclusion of Arginine in the P-SARM Synthase AI complex allows for a steady, continuous supply of L-Arginine for conversion to nitric oxide, allowing for a more effective product. Numerous research studies suggest the positive effects of L-Arginine and nitric oxide on increasing lean body mass, and possibly even mediating greater growth hormone response.* (4-7,14)

A combination of carefully selected ingredients which when combined produce amazing results like no other pre-workout before it.*

Grape Seed

OPCs (Oligomeric proanthocyanidins) are suggested by numerous studies to have the support a healthy rate of converting androgens to estrogens (a process known as aromatizing).* Compounds exhibiting aromatase inhibiting characteristics have been suggested to reduce SHBG (steroid hormone binding globulin) as well. This is important because this supports for an increase in free testosterone, which promotes longer, harder more intense workouts, rapid strength increases, greater protein synthesis, quicker recovery, and increased lipolysis (fat burning). This, coupled with the androgen-mimicking qualities of Icariin, gives the product a unique "hardness" enhancing quality unlike anything else available.* (15-21)

A combination of carefully selected ingredients which when combined produce amazing results like no other pre-workout before it.


Icariin is a potent phytochemical that has been suggested to have profound effects on anabolism.* Icariin exerts its efficacy through several different mechanisms of action: Via competition with glucocorticoids and increasing cAMP levels, by modulating estrogen receptor antagonism and by decreasing prolactin levels.* Several studies suggest that Icariin competes with glucocorticoids for various receptor sites, and thus may support a healthy Testosterone/Cortisol (T:C) ratio.* Icariin also blocks glucocorticoids from binding to cortisol receptors, hence antagonizing the actions of cortisol.* This alone creates an anabolic effect by positively skewing the Testosterone/Cortisol T:C ratio which is a trigger for greater anabolism, protein synthesis, increased aggression, and intensified muscle contractions.* (1-2,9,13-17)


Naringin, and its novel component Naringenin, also contribute profound effects within the P-SARM Synthase AI complex. Naringin (and Naringenin) exhibit remarkable anti-aromatase and estrogen-inhibiting properties by decreasing the cytochrome P450arom isoform.* This may support a healthy testosterone / estrogen ratio, and the combination of OPCs and naringenin act synergistically in reducing estrogen; allowing for more circulating free testosterone and all of its associated benefits.* Naringin and naringenin have also been suggested to enhance the metabolism of caffeine and PDE5 inhibitors such as icariin, allowing for these compounds to be much more effective on a per dose basis.* (22-29)

Cocoa Extract

Cocoa Extract is comprised of several different important constituents that support mood, cognitive awareness, and muscle contraction.* PEA, tyramine, and L-tyrosine are the most prevalent constituents of cacao, and have the biggest impact on the positive effects of the compound. The amino acid tyrosine has psycho-stimulant effects that support cognitive function, because tyrosine is a precursor to the neurotransmitter dopamine. Tyrosine supplementation has been suggested to increase dopamine and norepinephrine levels, which can be helpful for increasing athletic ability and cognitive function.* Tyrosine also has the ability to ward off exercise-related fatigue by creating a favorable dopamine / serotonin ratio, which can positively alter the subject’s state of mind and reduce mental fatigue.* (37-40)


Caffeine is a metabolic stimulant that heightens mental alertness and focus and supports muscle contraction and coordination. MXAC also exerts very strong effects on vasodilation in a process that begins with the activation of norepinephrine and the deactivation of cAMP-PDE (the enzyme that breaks down cAMP). When cAMP levels are increased, the blood vessels in skeletal muscle tend to relax and dilate. The result is more voluminous blood flow into the muscle, resulting in bulging vascularity and massive pumps.* Caffeine also contains significant amounts of theobromine; another vasodilator that ups the amount of nutrients and oxygen into the brain and skeletal muscle.* By blocking adenitric oxidesine uptake without activating adenitric oxidesine receptors, Caffeine triggers increased dopamine and serotonin levels which exerts a positive influence on mood and helps the subject maintain an improved state of mind and focus.* (30-36,40)

For Maximum Results, What Does
RPM® Stack Best With?



Lean Body Mass and Endurance

Drive® + RPM®

Stronger Pre-Workout

Fat Loss

Fat Free™ + RPM®

Lean Body Mass and Recovery



1. Tian L, Xin ZC, Yuan YM, Fu J, Liu WJ, Wang LL. Zhonghua Yi Xue Za Zhi. 2004 Jun 2;84(11):954-7. Effects of icariin on the expression of nitrogen oxide synthase isoforms in corpus cavernitric oxidesum of arterigenic

2. Xin ZC, Kim EK, Lin CS, Liu WJ, Tian L, Yuan YM, Fu J. Asian J Androl. 2003 Mar;5(1):15-8. Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities.

3. Tian L, Xin ZC, Yuan YM, Fu J, Liu WJ, Wang LL. Zhonghua Yi Xue Za Zhi. 2004 Jan 17;84(2):142-5. [Article in Chinese] Effects of icariin on intracavernitric oxidesal pressure and systematic arterial blood pressure of rat.

4. Chen J, Wollman Y, Chernichovsky T, Iaina A, Sofer M, Matzkin H. BJU Int. 1999 Feb;83(3):269-73. Effect of oral administration of high-dose nitric oxide donitric oxider L-arginine in men with organic: results of a double-blind, randomized, placebo-controlled study.

5. Klotz T, Mathers MJ, Braun M, Bloch W, Engelmann U. Effectiveness of oral L-arginine. Urol Int. 1999;63(4):220-3. PMID: 10743698

6. Stanislavov R, Nikolova V. pycnitric oxidegenitric oxidel and L-arginine. J Sex Marital Ther. 2003 May-Jun;29(3):207-13. PMID: 12851125

7. Kim NN, Christianson DW, Traish AM. Role of arginase in the male and female sexual arousal response. J Nutr. 2004 Oct;134(10 Suppl):2873S-2879S; discussion 2895S. Review. PMID: 15465804

8. Ying, Pan, Wei-Yun Zhang, Xing Xia, and Ling-Dong Kong, "Effects of Icariin on Hypothalamic-Pituitary-Adrenal Axis Action and Cytokine Levels in Stressed Sprague-Dawley Rats" Biol. Pharm. Bull., Vol. 29, 2399-2403.

9. Ning, H et al. Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Urology. 2006 Dec;68(6):1350-4.

10. PMID: 17169663 [PubMed - indexed for MEDLINE]

11. Jiang, Z. et al Effects of icariin on hypothalamic-pituitary-adrenal axis action and cytokine levels in stressed Sprague-Dawley rats. Biol Pharm Bull. 2006 Dec;29(12):2399-403. PMID: 17142971 [PubMed - indexed for MEDLINE]

12. Liu, W. Effects of icariin on nitric oxide synthase isoforms in castrated rats. Asian J Androl. 2005 Dec;7(4):381-8. PMID: 16281085 [PubMed - indexed for MEDLINE]

13. Xin, ZC Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Asian J Androl. 2003 Mar;5(1):15-8. PMID: 12646997 [PubMed - indexed for MEDLINE]

14. Bode-Boger SM, Boger RH, Galland A, et al. L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship. Br J Clin Pharmacol. 1998; 46:489-497.

15. Wascher TC, Posch K, Wallner S, et al. Vascular effects of L-arginine: anything beyond a substrate for the nitric oxide-synthase? Biochem Biophys Res Commun. 1997; 234:35-38.

16. Kijuma, I. et al Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res. 2006 Jun 1;66(11):5960-7.

17. Sanitric oxide, T. et al Anti-thrombotic effect of proanthocyanidin, a purified ingredient of grape seed. Thromb Res. 2005;115(1-2):115-21.

18. Eng, ET et al Suppression of estrogen biosynthesis by procyanidin dimers in red wine and grape seeds. Cancer Res. 2003 Dec 1;63(23):8516-22.

19. Fitzpatrick, DF et al Vasodilating procyanidins derived from grape seeds. Ann N Y Acad Sci. 2002 May;957:78-89.

20. Yu, H et al [Study of anti-atherosclerosic effect of grape seed extract and its mechanism] Wei Sheng Yan Jiu. 2002 Aug;31(4):263-5. Chinese.

21. Dell’Agli, H et al n vitro inhibition of human cGMP-specific phosphodiesterase-5 by polyphenols from red grapes.J Agric Food Chem. 2005 Mar 23;53(6):1960-5.

22. LeBail, JC et al Chalcones are potent inhibitors of aromatase and 17beta-hydroxysteroid dehydrogenase activities.Life Sci. 2001 Jan 5;68(7):751-61.

23. LeBail, JC et al Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities. Life Sci. 2000 Feb 25;66(14):1281-91.

24. LeBail, JC et al Aromatase and 17beta-hydroxysteroid dehydrogenase inhibition by flavonitric oxideids. .Cancer Lett. 1998 Nitric oxidev 13;133(1):101-6.

25. LeLain, L et al Inhibitors of human and rat testes microsomal 17beta-hydroxysteroid dehydrogenase (17beta-HSD).

26. Arayne, LS. Et al Grape fruit juice-drug interactions.Pak J Pharm Sci. 2005 Oct;18(4):45-57. Review.

27. Ho, PC et al. Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds. J Pharm Pharm Sci. 2001 Sep-Dec;4(3):217-27.

28. Fuhr, U Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man. Br J Clin Pharmacol. 1993 Apr;35(4):431-6.

29. Jetter, A. et al Effects of grapefruit juice on the pharmacokinetics of. Clin Pharmacol Ther. 2002 Jan;71(1):21-9.

30. Newton, R; Broughton LJ, Lind MJ, Morrison PJ, Rogers HJ, Bradbrook ID (1981). "Plasma and salivary pharmacokinetics of caffeine in man". European Journal of Clinical Pharmacology 21 (1): 45-52.

31. Graham T, Rush J, van Soeren M (1994). "Caffeine and exercise: metabolism and performance.". Can J Appl Physiol 19 (2): 111-38.

32. Fredholm B, Bättig K, Holmén J, Nehlig A, Zvartau E (1999). "Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.". Pharmacol Rev 51 (1): 83-133

33. Verkhratsky A. (2005). "Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons". Physiol. Rev. 85 (1): 201-279. Dews, P.B. (1984). Caffeine: Perspectives from Recent Research. Berlin: Springer-Valerag.

34. Ivy, JL; Costill DL, Fink WJ, Lower RW (1979 Spring). "Influence of caffeine and carbohydrate feedings on endurance performance". Med Sci Sports 11(1): 6-11.

35. Graham, TE; Spriet, LL (1991 Dec). "Performance and metabolic responses to a high caffeine dose during prolonged exercise". J Appl Physiol 71 (6): 2292-8.

36. Trice, I; Haymes, EM (Mar 1995). "Effects of caffeine ingestion on exercise-induced changes during high-intensity, intermittent exercise". Int J Sport Nutr5 (1): 37-44

37. William Gervase Clarence-Smith (2000). Cocoa and Chocolate, 1765-1914. London: Routledge, 10, 31.

38. Usmani O; Belvisi M, Patel H, Crispinitric oxide N, Birrell M, Korbonits M, Korbonits D, Barnes P (2005). "Theobromine inhibits sensory nerve activation and cough.". FASEB J 19 (2): 231-3.

39. MATISSEK R., Evaluation of xanthine derivatives in chocolate: nutritional and chemical aspects.

40. Smit HJ, Gaffan EA, Rogers PJ. (2004) Methylxanthines are the psycho-pharmacologically active constituents of chocolate. PsychopharmacologyNitric oxidev;176(3-4):412-9.

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Applied Nutriceuticals RPM Purchase Information

Order today using our 100% secure server and get it at the lowest prices in the world with our fast, inexpensive 2-3 day shipping! NOBODY beats our overall price!

110 Capsules
$44.95 $29.95 In Stock
240 Capsules
$89.99 $52.78 In Stock

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110 Capsules
$44.95 $29.95 In Stock
240 Capsules
$89.99 $52.78 In Stock
What's in Applied Nutriceuticals RPM?
110 Capsules
Supplement Facts
Serving Size1Capsule
Servings Per Container110
Amount Per Capsule.......................500mg
P-SARM Synthase Al Complex™ (Proprietary Blend)290mg
Grape Seed Extract (95% Oligometric Proanthocyandins)*
Epimedium Extracts (20% Icariin)*
Naringenin (98% Extract)*
Methyl AMP Complex (Proprietary Blend)210mg
Cocao Extract* (Standardized To 20% Theobromine)*
Natural Caffeine Anhydrous*
Theobromine (99%)*
* Daily Value not established
Inactive Ingredients:
Gelatin, USP Talc, Magnesium Carbonate, Silicon Dioxide, NSF Carnuba, Candurin Silver Fine, FD&C Red #40

Directions For RPM: Take on empty stomach, 1 hour pre-workout. Start with the lower recommended dosage and if needed, increase until desired effect is reached.

Suggested Dosage
(Taken 1 hour Pre-workout)
Up to 150 1-2 Capsules
Up to 200 3-4 Capsules
Up to 250 2-4 Capsules
250 lbs and over 3-5 Capsules

Warnings: This product is only intended to be consumed by healthy adults 18 years of age or older. Do not use if you are pregnant or nursing. Before using product, seek advice from a physician if you are unaware of your current health condition or have any pre-existing medical condition including but not limited to kidney disease or if you are taking any prescription or over the counter medication. Do not use if you are pregnant, nursing, prone to dehydration or exposed to excessive heat. Discontinue use and consult your health care professional if you experience any adverse reaction to this product. Before beginning any weight loss program, consult your health care providers. KEEP OUT OF REACH OF CHILDREN.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.