Applied Nutriceuticals: HGH Up
Hormone Boosting Capsule For Muscle Growth*
Stimulates Growth Of New Muscle Cells And Amplifies Muscle Size And Hardness*
Applied Nutriceuticals HGH Up Product Guide
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IN GH LEVELS!*
What is HGH UP and What Does it Do?
HGH UP® is the world’s first “Hybrid Anabolic/Near Hormonal” product.* In other words, it’s able to support physiological benefits while minimizing potential side effects and disruption of endogenous hormone levels post-usage.*
The Basics of HGH UP
- Helps support a healthy level of somatostatin; a hormone that limits Growth Hormone production*
- Promotes serum HGH production in the pituitary*
- Supports the output of growth hormone and local IGF-1 levels*
What Makes HGH UP the Most
Effective GH Booster on the Market?
Over the last 20 years, a variety of products that claim to boost HGH orally have been promoted in the US sports supplement market. The vast majority of these products have been completely ineffective for several reasons:
Growth hormone is a peptide (a long chain amino acid structure), that cannot be taken in an oral form, due to the destruction of the sequence by the acidic environment of the stomach. Any supplement containing “oral growth hormone” is a scam. (47)
Many products use a combination of amino acids such as arginine and lysine in “kitchen sink” formulas, and claim that their combination is “scientifically proven” to work. Many amino acids boost growth hormone levels, but most of the time, it is only when taken in completely unattainable dosages that would make a normal person extremely sick. And the correct dosage is in gram amounts, not in the milligram range offered in many of these products. (41-47)
Even if these products allow for a viable release of GH, there is nothing present to inhibit somatostatin, which has been found to be the biggest factor in controlling GH levels. (9-15)
Many of these products are powdered mixes that contain sugar, sweeteners, or other compounds that may increase blood sugar. As discussed above, this will render the product virtually useless due to the inverse relationship between glucose and growth hormone.
HGH UP♂ differs from these compounds because of the nature of the formulation. Every compound in the product is designed to work in concert with the other components; no filler or ineffective components are found in this product.
HGH UP♂ utilizes the latest research on compounds which have been overlooked by other companies. The secret of the product is in the complexity, effectiveness and synergism of the blend.
HGH UP♂ is the first product to positively manipulate somatostatin; this alone puts it in a class by itself.* (9-15)
HGH UP♂ also utilizes components that boost androgen levels, support the number and function of androgen receptors, and promote an overall anabolic environment in which levels of testosterone and GH are optimized.* (24-27)
MUCUNA PRURIENS, VITAMIN B6 & L-DOPA
Support Growth Hormone Output and Testosterone Production While Concurrently Decreasing Somatostatin and Prolactin.*
HGH UP♂ contains highly concentrated L-Dopa derived from Mucuna Pruriens. Mucuna Pruriens is an Ayurvedic Herb that has L-Dopa-increasing qualities (32). L-Dopa has been suggested to support levels of growth hormone in human subjects when administered orally.* (1-3,33)
Oral viability in HGH UP♂ critical for product effectiveness, as growth hormone cannot be absorbed and is rendered ineffective due to the fragility of the ingredients. Several good examples are synthetic growth hormone and growth hormone releasing hormone. These compounds cannot be administered orally; because of their fragile amino acid sequence is destroyed by stomach acids. This also holds true with the vast majority of the so-called “GH Boosters” and “Peptides” commonly found in sports nutrition products.
L-Dopa and Dopamine have also been suggested to help reduce prolactin, a hormone that suppresses male testosterone production. Prolactin also has a positive correlation with a second hormone called somatostatin, which decreases the amount and effectiveness of circulating growth hormone. Therefore, by lowering prolactin (and consequently somatostatin) levels, HGH UP♂ supports both testosterone and GH production.* (38-39).
Vitamin B6 is also included in the formula for HGH UP♂, as it can also help promote healthy prolactin levels and support the night-time peak of GH release pulse, while at the same time increasing the rise in GH associated with exercise by as much as 23%.* (7)
Increasing AChE Inhibition and
Mean serum GH by Decreasing Somatostatin*
Huperzine-A is a strong acetylcholine esterase (AChE) inhibitor. Acetylcholine esterase inhibitors have been suggested in numerous scientific studies to inhibit somatostatin via a variety of synergistic biomechanisms; all of which contribute to increased levels of growth hormone.* (9-18)
Somatostatin is a hormone that exerts effects on anterior pituitary as well as pancreatic, liver and gastrointestinal function. (40-43)
Somatostatin is of extreme importance because it directly effects growth hormone release and is a major regulating factor in growth hormone output.
By inhibiting somatostatin, overall mean serum GH may increase.* (41-42)
Somatostatin inhibits GH secretion indirectly via antagonizing GHRH secretion (41-43).
Consequently, the Huperzine-A, in HGHUP♂ increases the length, intensity, duration of growth hormone pulses and supports mean serum GH levels.*(8,10,12-17,19-20)
GREEN TEA EXTRACT & EGCG
Supports Dopa Decarboxylase Inhibition and the
AChE-inhibiting Effects of HGH UP♂
Dopamine crosses the blood/brain barrier poorly, and cannot exert optimal effects on target receptors unless enough of the compound reaches the brain. L-Dopa is freely absorbed across this barrier, and when L-dopa crosses the barrier readily, growth hormone levels increase.* (1-6,32-33)
L-Dopa is most effective when conversion of L-Dopa to dopamine is mediated by a decarboxylase inhibitor. A decarboxylase inhibitor is a substrate that inhibits the metabolism of one biological entity into another biological entity. (2-5,19-20,37)
A decarboxylase inhibitor is generally administered at the same time as L-Dopa / Mucuna in order to reduce conversion of the L-dopa into dopamine in the periphery. (−)-epigallocatechin-3-O-gallate (EGCG), which is found in high amounts in the green tea extract used in HGH UP♂, is a possible decarboxylase inhibitor.*The decarboxylase-reducing qualities of EGCG have been suggested by several recent studies, in that EGCG seems to prevent L-dopa from converting into dopamine; allowing more significant levels of L-dopa to reach the brain and support growth hormone levels.* (1-5,37)
EGCG has also been suggested to increase the effects of Huperzine A on acetylcholine esterase inhibition by increasing the transport of Huperzine-A by serum albumin. This allows for greater amounts of acetylcholine to be present, therefore allowing for greater mean serum growth hormone.* (19-20)
L-CARNITINE-L-TARTRATE & MAGNESIUM
Increasing Androgen Receptor Number and Density, and the
Creation of a Better Binding Environment!
L-Carnitine L-Tartrate is an amino acid that has been suggested to increase the number of androgen receptors in skeletal muscle, creating a better binding environment for testosterone and other androgens by allowing for a greater number of intact receptors available for hormonal interactions.*(21-23)
Magnesium has been suggested by more recent studies to inhibit the binding of steroid hormone binding globulin (SHBG) and free testosterone.* SHBG binds free testosterone and allows it to be excreted from the body, without binding the androgen receptor. Magnesium keeps this from happening by altering the binding affinity of testosterone to SHBG; which may allow for increased amounts of free testosterone to remain active in the bloodstream.*(24)
Other human research suggests that supplemental magnesium, when taken along with other ingredients like DHEA and Zinc, can significantly increase free testosterone.*(25-27)
Therefore, HGH UP♂ allows for greater numbers of androgen receptors and a better binding environment for testosterone in skeletal muscle.* This is a new breakthrough in sports supplementation as HGH UP♂ creates a better target for circulating free testosterone, allowing for greater binding of testosterone to the extra receptors which leads to increased protein synthesis, better recovery, and increased muscle mass.*
MUCUNA PRURIENS & CHLOROPHYTUM BORIVILLANUM
Increasing Testosterone Levels!
Mucuna Pruriens has been suggested in several recent human studies to support testosterone levels in animal studies and humans, via prolactin inhibition.* Prolactin, as mentioned earlier, is a hormone that suppresses male testosterone production. (30-31,34-36, 38-39).
The ethanolic and sapogenic extracts of Chlorophytum Borivaillanum have also been suggested in animal studies to support testosterone, and anecdotal data from products containing this compound also point to supporting testosterone and lean body mass for users of this phyto-androgenic compound.* However, the mechanism of action of Chlorophytum is poorly understood. (28- 29)
Don’t Believe Us? We have the science to back it up!
For Maximum Results, What Does
HGH UP Stack Best With?
Gain Lean Muscle While
Losing Body Fat
Fat Free™ + DRIVE® + HGH-UP®
Put on Mass While Keeping
Away Body Fat
Fat Free™ + Neovar® + DRIVE® + HGH-UP®
Build Muscle While
DRIVE® + Neovar®
Fat Free™ + LIPO-PM®
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2. Schönberger W, Grimm W, Ziegler R. The effect of nacom (L-dopa and L-carbidopa) on growth hormone secretion in 75 patients with short stature. Eur J Pediatr. 1977 Dec 30;127(1):15-9.
3. Schönberger W, Ziegler R, Brodt B, Grimm W. HGH secretion after oral application of L-dopa and L-carbidopa. Eur J Pediatr. 1976 Jun 8;122(3):195-200.
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7. Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise. 1982 Aug 12;307(7):444-5.
8. Barletta C, Sellini M, Bartoli A, Bigi C, Buzzetti R, Giovannini CInfluence of administration of pyridoxine on circadian rhythm of plasma ACTH, prolactin and somatotropin in normal subjects.Boll Soc Ital Biol Sper. 1984 Feb 28;60(2):273-8
9. Gordon RK, Haigh JR, Garcia GE, Feaster SR, Riel MA, Lenz DE,Aisen PS, Doctor BP. Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman. Chem Biol Interact. 2005 Dec 15;157-158:239-46. Epub 2005 Oct 26.
10. Wang R, Yan H, Tang XC. Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. Acta Pharmacol Sin. 2006 Jan;27(1):1-26
11. Kelijman M, Frohman LA. The role of the cholinergic pathway in growth hormone feedback. J Clin Endocrinol Metab. 1991 May;72(5):1081-7
12. Liang YQ, Tang XC. Comparative studies of huperzine A, donepezil, and rivastigmine on brain acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels in freely-moving rats. Acta Pharmacol Sin. 2006 Sep;27(9):1127-36
13. Giustina A, Bossoni S, Bodini C, Doga M, Girelli A, Buffoli MG,Schettino M, Wehrenberg WB. The role of cholinergic tone in modulating the growth hormone response to growth hormone-releasing hormone in normal man. Metabolism. 1991 May;40(5):519-23
14. Friend K, Iranmanesh A, Login IS, Veldhuis JD Pyridostigmine treatment selectively amplifies the mass of GH secreted per burst without altering GH burst frequency, half-life, basal GH secretion or the orderliness of GH release. Eur J Endocrinol. 1997 Oct;137(4):377-86
15. Dinan TG, O'Keane V, Thakore J. Pyridostigmine induced growth hormone release in mania: focus on the cholinergic/somatostatin system. Clin Endocrinol (Oxf). 1994 Jan;40(1):93-6
16. Thakore JH, Coffey I, Dinan TG. Time dependency of pyridostigmine-induced growth hormone response. J Basic Clin Physiol Pharmacol. 1994 Apr-Jun;5(2):117-2
17. Li YX, Zhang RQ, Li CR, Jiang XH. Pharmacokinetics of huperzine A following oral administration to human volunteers. Eur J Drug Metab Pharmacokinet. 2007 Oct-Dec;32(4):183-7.
18. Haigh JR, Johnston SR, Peppernay A, Mattern PJ, Garcia GE, Doctor BP, Gordon RK, Aisen PS. Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase. Chem Biol Interact.2008 Sep 25;175(1-3):380-6.
19. Xiao J, Chen X, Zhang L, Talbot SG, Li GC, Xu M. Investigation of the mechanism of enhanced effect of EGCG on huperzine A's inhibition of acetylcholinesterase activity in rats by a multispectroscopic method. J Agric Food Chem. 2008 Feb. 13:56(3) 910-915.
20. Zhang L, Cao H, Wen J, Xu M. Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin.
21. DI MARZIO L. (1) ; MORETTI S. (2) ; D'ALO S. (1) ; ZAZZERONI F. (1) ; MARCELLINI S. (2) ; SMACCHIA C. (3) ; ALESSE E. (1) ; CIFONE M. G. (1) ; DE SIMONE C. (1) ; Acetyl-l-carnitine administration increases insulin-like growth factor 1: Correlation with its suppressive effect on lymphocyte apoptosis and ceramide generation.
22. Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ,Rubin MR, French DN, Silvestre R, Hatfield DL, Van Heest JL, Vingren JL, Judelson DA, Deschenes MR, Maresh CM. Androgenic responses to resistance exercise: effects of feeding and L-carnitine. Med Sci Sports Exer., 2006 Jul: 38(7): 1288-96.
23. Kraemer WJ, Volek JS, French DN, Rubin MR, Sharman MJ, Gómez AL, Ratamess NA, Newton RU, Jemiolo B, Craig BW, Häkkinen K.The effects of L-carnitine L-tartrate supplementation on hormonal responses to resistance exercise and recovery. J Strength Cond. Res. 2003 Aug: 17(3): 455-462,
24. André C, Berthelot A, Robert JF, Thomassin M, Guillaume YC.Testimony of the correlation between DHEA and bioavailable testosterone using a biochromatographic concept: effect of two salts. J Pharm Biomed An., 2003 Dec 4: 33(5): 911-21.
25. Excoffon L, Guillaume YC, Woronoff-Lemsi MC, André C. Magnesium effect on testosterone-SHBG association studied by a novel molecular chromatography approach. J Pharm Biomed An. 2009 Feb. 20: 49(2). 175-180.
26. Age-Related Eye Disease Study Research Group (2001). “A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc. Arch Opthalmology. 119(10): 1417.
27. Berdanier, Carolyn D.; Dwyer, Johanna T.; Feldman, Elaine B. (2007). Handbook of Nutrition and Food. Boca Raton, Florida: CRC Press.
28. Thakur M. and Dixit V.K.* EFFECT OF CHLOROPHYTUM BORIVILIANUM ON ANDROGENIC & SEXUAL BEHAVIOR OF MALE RATS Indian Drugs 2006 April 43(4): 300-306
29. Kothari S.K., Safed Musli (Chlorophytum borivilianum) revisited,Journal of Medicinal and Aromatic Plants. 2004, 26, 60-63.
30. Saxena S and Dixit V.K: Role of total alkaloids of Mucuna pruriens Baker in male rats, Indian Journal of Natural Products. 1987, 3(2), 3-7.
31. Unnithan A.R. and Tandon V.L: Role of growth hormone . Indian Journal of Experimental Biology.1982,20,734-737.
32. Modi KP, Patel NM, Goyal RK. Estimation of L-dopa from Mucuna pruriens LINN and formulations containing M. pruriens by HPTLC method Chem Pharm Bull (Tokyo). 2008 Mar: 56(3): 357-359.
33. Tharakan B, Dhanasekaran M, Mize-Berge J, Manyam BV. Mucuna pruriens. Phytother Res. 2007 Dec;21(12):1124-6.
34. Ahmad MK, Mahdi AA, Shukla KK, Islam N, Jaiswar SP, Ahmad S. Effect of Mucuna pruriens on profile and biochemical parameters.. 2008 Sep;90(3):627-35. Epub 2007 Nov 14.
35. Shukla KK, Mahdi AA, Ahmad MK, Shankhwar SN, Rajender S, Jaiswar SP. Mucuna pruriens its action on the hypothalamus-pituitary-gonadal axis. Fertil Steril. 2008 Oct 28. [Epub ahead of print]
36. Shukla KK, Mahdi AA, Ahmad MK, Jaiswar SP, Shankwar SN, Tiwari SC .Mucuna pruriens.Evid Based Complement Alternat Med. 2007 Dec 18. [Epub ahead of print]
37. Bertoldi M, Gonsalvi M, Voltattorni CB. Green Tea polyphenols: Novel irreversible inhibitors of dopa decarboxylase Biochem Biophys Res Commun. 2001 Jun 1;284(1):90-3.
38. Vaidya RA, Aloorkar SD, Sheth AR, Pandya SK. Activity of bromoergocryptine, Mucuna pruriens and L-dopa in the control of hyperprolactinaemia. Neurol India. 1978 Dec;26(4):179-82.
39. Vaidya RA, Sheth AR, Aloorkar SD, Rege NR, Bagadia VN, Devi PK, Shah LP. The inhibitory effect of the cowhage plant- mucuna pruriens-and L-dopa on chloropromazine-induced hyperprolactinemia. Neurol India. 1978 Dec;26(4):177-8.
40. Epelbaum J, Guillou JL, Gastambide F, Hoyer D, Duron E, ViolletSomatostatin, An old story coming of age? C. Prog Neurobiol. 2009 Jul 10.
41. Nikolaeva AA, Koroleva SV, Ashmarin IP. [Research of interactions in the dopamine-serotonin-somatostatin system promises new outlook in fundamental and practical respects] Nikolaeva AA, Koroleva SV, Ashmarin IP. Eksp Klin Farmakol. 2009 Mar-Apr;72(2):60-4. Review
42. Cordido F, Isidro ML, Nemiña R, Sangiao-Alvarellos S.Ghrelin and growth hormone secretagogues, physiological and pharmacological aspect. Curr Drug Discov Technol. 2009 Mar;6(1):34-42.
43. Strowski MZ, Blake AD. Function and expression of somatostatin receptors of the endocrine pancreas. Mol Cell Endocrinol. 2008 May 14;286(1-2):169-79.
44. Haff, G. Lecture Notes for Graduate Study: Hormonal Parameters Relevant to Training. Appalachian State University, 2000.
45. Khoo, B. and Grossman, A. Normal Physiology of the Hypothalamus and Anterior Pituitary. St. Bartholomew’s Hospital, West Smithfield, London. Neuroendocrinology, Hypothalamus, and Pituitary. 2007 Ch. 1 Lecture.
46. Various sources. Anecdotal Information concerning the usage of AChE inhibitors with synthetic GH.
47. Applied Nutriceuticals Research. Unpublished alpha testing for new somatotropin-enhancing sports supplement. Charlotte, NC. 2009
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Directions For HGH Up: Take 5 capsules before bed on an empty stomach.
Warnings: This product is only intended to be consumed by healthy adults 18 years of age or older. Do not use if you are pregnant or nursing. Before using product, seek advice from a physician if you are unaware of your current health condition or have any pre-existing medical contrition including by not limited to kidney disease or if you are taking any prescription or over the counter medication. Do not use if you are pregnant, nursing, prone to dehydration of exposed to excessive heat. Discontinue use and consult your health care professional if you experience any adverse reaction to this product. Before beginning any weight loss program, consult your health care providers. Store at room temperature and avoid excessive heat. Do not use if inner safety seal is broken or missing. KEEP OUT OF REACH OF CHILDREN.