| By BigVinceMOD (24.95.120.194) on Tuesday, July 24, 2001 - 11:07 pm: Edit |
Pharmaceutical Name: Clomiphene Citrate
Brand Names: CLOMID
Description: Clomid is a brand name for the drug clomiphene citrate. It is typically prescribed for women to aid in ovulation. In men, the application of Clomid causes an elevation of follicle stimulating hormone and luteinizing hormone. As a result, natural testosterone production is also increased. This effect is obviously beneficial to the athlete, especially at the conclusion of a cycle when endogenous testosterone levels are subnormal. When an athlete discontinues the use of steroids, his testosterone levels will most likely be suppressed. If endogenous testosterone levels are not brought to normal, a dramatic loss in size and strength may occur. Clomid plays a crucial role in preventing this crash in athletic performance. Bodybuilders find that a daily intake of 50-100 mg of clomiphene citrate over a two week period will bring endogenous testosterone production back to an acceptable level. Clomid will gradually raise testosterone levels over its period of intake. Since an immediate boost in testosterone is often desirable, athlete will commonly use HCG (human chorionic gonadotropin) for a couple of weeks, and the continue treatment with Clomid. Clomid is also effective as an anti-estrogen. Most athletes will suffer from an elevated estrogen level at the conclusion of a cycle. A high estrogen level combined with a low testosterone level puts an athlete in serious risk of developing gynocomastia. With the intake of Clomid, the athlete gets the dual effect of blocking out some of the effects of estrogen, while also increasing endogenous testosterone production.
Testosterone production begins at the hypothalamus,which scans blood levels of estrogens,androgens and other pertinent hormones.In a presence of low androgens and estrogens the hypothalamus will produce leutenizing-hormone-releasing-hormone(LHRH)which in turn stimulates the pituitary to produce leutenizing hormone(LH).LH then signals the leydig cells in the testicles to begin producing testosterone.Hence the Hypothalamic Pituitary Testicular Axis(more commonly referred to as H-P-T-A),as production is ran in that particular order. Now on to the clomid...
Clomid is a selective estrogen receptor modulator (much like nolvadex, only their binding capacities are more aggressive in seperate areas). Clomid stimulates L-H-R-H/LH production by binding to ESTROGEN receptors on the hypothalamus and pituitary, thus giving the illusion of a low presence of circulating estrogen.Note the key word here-ESTROGEN.CLOMID DOES NOT BIND ANDROGEN. Therefore, on a cycle of moderate to high amounts of ANDROGENS, clomid will have no effect whatsoever on endogenous testosterone production,as we are in a state of ANDROGENIC inhibition. It's post cycle,when blood levels of androgens begin to normalize and the typical estrogenic rebound/lag occurs,that clomid is able to re-initialize this process of testosterone production.Hope this clears up how clomid works and why to save it for post cycle,unless you're using it as an anti-estrogen...
How do we know when to administer clomid therapy,and how much should we use to get the desired effects?First you have to figure out the activity life/clearance time of your particular ester.They don't have to be completely cleared from your system,just enough that androgen levels are within normal to high normal ranges.For instance sust's longest acting and most potent ester,the undecanoate ester clears your system in roughly 3-4 weeks.So beginning clomid therapy 3 weeks after your last injection would be ideal.This is the pattern I would run my clomid in...
Day 1)300mgs...2 tabs every 4 hours or so.This will drive up blood levels of the drug for an immediate "therapeutic" response(one that would normally take many consecutive days of usage to be reached)and get the drug working aggressively towards re-initializing endogenous hormonal production.
Days 2-11)100mgs/day(bothtabs can be taken together now,as it's half life is so long it will make no difference...
Days 12-21)50mgs/day...
Day 22)DONE!
Effective Dose: 50MG every other day throught a cycle.
Pharmaceutical Price: $2-10 per pill.
Average Street Price: Current prices are between $2-$4 per 50 mg tab. Generics such as Clomiphene citrate by Anfarm in Greece are frequently seen on the black market and can be purchased for about $1 a tablet.
Side Effects: In relation to toxicity and side effects, Clomid is considered a fairly safe drug. Bodybuilders seldom experience any problems, but possible side effects include hot flashes and temporary blurred vision.
Counterfeits: Legitimate clomiphene citrate is widely available on the black market. Until recently, it was relatively easy to get through foreign mail order. However, since the DEA is playing an active role in pursuing mail-order operations catering to athletes, Clomid is becoming harder to obtain and counterfeits are becoming more common.
Effectiveness Rating: 9
| By BigVinceMOD (24.95.120.194) on Saturday, July 28, 2001 - 08:26 pm: Edit |
Clomid is not an anabolic/androgenic steroid. Since it is a synthetic estrogen it belongs, however, to the group of sex hormones. In school medicine Clomid is normally used to trigger ovulation. Clomid, by setting in motion the process of releasing hormones, stimulates the release of gonadotropin and triggers ovulation in women with anovulatory cycles and who are sterile because of this. Although this is actually a drug destined for women its effect on men is undisputed. The manufacturer of Dyneric,the Merrell Dow Pharma GmbH, writes in its package insert for the German version of Clomid: "Dyneric causes an improved activity between mid-brain, pituitary gland, and ovaries." What however is not mentioned is that Dyneric also improves the activity between mid-brain (hypothalamus), pituitary gland thypophysis), and testes in men. Clomid has a strong influence on the hypothalamohypophysial testicular axis. It stimulates the hypophysis to release more gonadotropin so that a faster and higher release of FSH (follicle stimulating hormone) aud LH (luteinizing hormone) occurs. This results in an elevated endogenous (body's own testosterone level. Clomid is especially effective when the body's own testosterone production, due to the intake of anabolic/androgenic steroids, is suppressed. In most cases Clomid can normalize the testosterone level and the spermatogenesis (sperm development)within 10-14 days. For this reason Clomid is primarily taken after steroids are discontinued. At this time it is extremely important to bring the testosterone production to a normal level as quickly as possible so that the loss of strength and muscle mass is minimized. Even better results can be achieved if Clomid is combined with HCG or when Clomid is used after the intake of HCG. The difference between Clomid and HCG lies in the fact that Clomid has a direct influence on the hypothalamus and the hypophysis, thus regenerating the entire regulating cycle while HCG imitates the effect of the luteinizing hormone (LH) which stimulates the Ledig's cells fo produce more testosterone. Since HCG, unlike Clomid, leads to a distinctly elevated plasmatestosterone level within a few hours, many athlets first take HCG and then Clomid (see also HCG).
Paradoxically, although Clomid is a synthetic estrogen it also works as an antiestrogen. The reason is that Clomid has only a very low estrogenic effect and thus the stronger estrogens which, for example form during the aromatization of steroids, are blocked at the receptors. These would include those that develop during the aromatizing of steroids. This does not prevent the steroids from aromatizing but the increased estrogen is mostly deactivated since it cannot attach to the receptors. The inereased water retention and the possible signs of feminization can thus be reduced or even completely avoided. Since the antiestrogenic effect of Clomid is lower than those found in Proviron, Nolvadex, and Teslac it is mainly taken as a testosterone stimulant. From the German book Doping By Brigitte Berendonk the reader can learn that Clomid is not only used in bodybuilding: "During the 1980's Clomiphene (table 2) has been used, a medication that promotes the production of the body's own stimulating hormone, gonadotropin, which in turn increases the testosterone level. - It is, for example, administered to women as a so-called antiestrogen to trigger ovulation ("ovulation stimulator").Clomiphene (usually the Hungarian compound Clostilbegyt) was used by rowers (resp. Prof. Dr. Herbert Gurtler) and weightlifers (Dr Lathan; p. 187) since the late 1970's. Increasingly, it was used in other sports disciplines as well, including track and field athletics. Riedel, at the time, happily made the handwritten entry in his notebook: "Substance that is not an anabolic: generally traceable but is not a doping substance." The dosages were horrendous. I found entries of up to l5 times 100mg daily and the report that the positive effect lasts up to 20 days after the last tablet is taken. And it was already assured since 1982 that the increased testosterone production after doping with Clomiphene did not reveal traits of the T/E quotient (testosterone/epitestosterone quotient, the author)during doping tests.
Side effects of Clomid are very rare if reasonable dosages are taken. Possible side effects are climacteric hot flashes and occasional visual disturbances which can manifest themselves in blurred vision, giving flickering or flashing. Should visual distuibances occur, the manufacturer recommends discontinuing Clomid treatment. Inadequate liver functions cannot be excluded;however,they are very unlikely in women enlargement of the ovaries and abdominal pain can occur since Clomid stimulates the ovaries. When taking Clomid multiple pregnancies are possible as well. As for the dosage, 50-100 mg/per day(1-2 tablets) seems to be sufficient. The tablets are usually taken with fluids after meals. If several tablets are taken it is recomended that they be administered in equal doses distributed throughout the day. The duration of intake should not exceed 10 to 14 days. Most athlets begin with 100 mg/day taking one 50mg tablet every morning and evening after meals. After the fifth day the dosage is often reduced to only one 50mg tablet per day. It is normally not necessary to take the compound for more than 10 days in order to increase the endogenus testosterone production. Since Clomid should not be taken for a prolonged time its application as an antiestrogen must be excluded because, for that purpose, it would have to be taken for several weeks. Clomid is relatively expensive. A package with 10 tablets costs approx. $35 - 45 on the black market. Fortunately, since the intake is only for a brief time, the financial burden usually becomes acceptable. The foreign compounds such as the Spanish Omifin are considerably cheaper and cost less than $2 per tablet.
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