Whey Protein Isolate In Resistance Training!

Whey is a type of protein found in milk. It is digested and absorbed into the body very fast which has led to people suggesting its use in acute states of muscle catabolism, e.g. after a workout... Learn more.

Article Summary:
  • Whey is a type of protein found in milk.
  • Whey protein would be best to acutely increase protein synthesis.
  • Whey protein is a more efficient protein source than egg protein.
  • This article will introduce the subject of whey protein in the context of resistance training. This article will not evaluate branded supplements.

    It will discuss the scientific evidence surrounding an active ingredient. I am not affiliated with any supplement company and thus these articles are non-bias. If it works it works, if it doesn't it doesn't.

    This Article Will Introduce The Subject Of Whey Protein In The Context Of Resistance Training.
    Enlarge Click Image To Enlarge.
    This Article Will Introduce The Subject Of
    Whey Protein In The Context Of Resistance Training.

      arrow View Whey Protein Products Sorted By Top Seller Here.
      arrow View Whey Protein Isolate Products Sorted By Top Seller Here.

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    What Is Whey protein?
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    Whey is a type of protein found in milk. It is digested and absorbed into the body very fast which has led to people suggesting its use in acute states of muscle catabolism, e.g. after a workout or upon waking in the morning.

    Essentially whey protein with fat and carbohydrate (lactose) removed so that less than 90% of the product is composed of protein (i.e. less than 90g out of every 100g). Hydrolysed whey protein is where peptides are further broken down to make absorption faster.

    Whey Is A Type Of Protein Found In Milk.
    Enlarge Click Image To Enlarge.
    Whey Is A Type Of Protein Found In Milk.

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    What Does It Do?
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    There are a variety of benefits of consuming whey protein, these include:

    • Fighting cancer (more precisely oxidant stress, as cysteine can be used to make glutathione to counter free radicals).
    • Diabetes sugar control: the proteins may delay glucose absorption, and satiate the individual so they may have lower portion sizes.
    • Helping infants grow and preventing disease (these are based on the fact breast-milk contains whey, the same effects are not seen with formula milk containing whey).
    • Changes in body composition and muscular strength.

    We are only going to discuss the last point in this article.

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    Why Is It Supposed To Be Useful?
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    Resistance training results in increases in lean body mass (LBM) through a variety of mechanisms. One such mechanism is by causing micro-tears in the muscle fibers.

    Once we eat and insulin levels rise, the body shuttles more protein into the muscles to make the cells bigger (hypertrophy) and consequently stronger so next time it will not tear as easily. (Note that although muscle size is not the only factor affecting strength, it is a very important factor).

    Resistance Training Results In Increases In Lean Body Mass (LBM) Through A Variety Of Mechanisms.
    Enlarge Click Image To Enlarge.
    Resistance Training Results In Increases In Lean
    Body Mass (LBM) Through A Variety Of Mechanisms.

    Because weight training is a catabolic activity (it breaks down the body tissues such as muscle), it is logical that upon completion of the workout, one would want to reverse this to an anabolic state as fast as possible.

    This is where whey protein comes in. Whey protein is said to have:

    1. A faster rate of absorption (absorption kinetics) even compared to the same dose of essential amino acids (EAAs).
    2. A greater biological value (BV) than any other protein source.

    As such whey protein is associated with a short, sharp rise in plasma amino acids and greater protein synthesis than slower digesting proteins such as casein. However due to whey's rapid absorption and short-lived effects, casein may be more efficacious for longer-term prevention of protein breakdown.

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    Essentially whey protein would be best to acutely increase protein synthesis and at all other times, slower digesting proteins like casein would be useful to prevent muscle breakdown.

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    What Is Biological Value (BV)?
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    Biological value simply refers to how much of the protein ingested is broken down and used to synthesize proteins the body needs. It is expressed either as an absolute number (called the 'true percentage utilization') or percentage relative to another protein (this is called percentage utilization relative to another already established and utilizable protein source, most commonly egg).

    Egg protein is the 'gold standard' and is thus given a value of 100%. Whey protein isolates have been found to reach BVs greater than 100%.

    Whey Protein Isolates Have Been Found To Reach BV's Greater Than 100%.
    Enlarge Click Image To Enlarge.
    Whey Protein Isolates Have Been
    Found To Reach BV's Greater Than 100%.

    Theoretically, this should mean whey protein is a more efficient protein source than the gold standard of egg. BV can be seen as an indicator of the quality of protein.

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    Why Does WPI Have A High BV?
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    BV depends on several factors; its preparation (e.g. cooking may denature proteins), concomitant vitamins and minerals (which may compete or enhance absorption) and most importantly amino acid profile.

    There are 9 essential amino acids (EAAs) meaning your body can't make them and they must be obtained from the diet. The amino acid that usually limits the biological availability of protein is lysine.

    Lysine:
    L-Lysine is a necessary building block for all protein in the body. L-Lysine plays a major role in calcium absorption; building muscle protein; recovering from surgery or sports injuries; and the body's production of hormones, enzymes, and antibodies.

    This also explains why sources of protein such as pulses, starches, fruits, etc. have low biological value - as they lack at least one of the essential amino acids. This is what is meant when people refer to a protein-containing food as 'incomplete'.

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    Does It Deliver?
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    dot Cribb Et Al 2006 (Casein Protein Vs. Hydrolysed WPI): dot

      Methods: In a double-blind study, 11 recreational male bodybuilders were supplemented with 1.5g/kg/bodyweight of hydrolyzed whey protein isolate (hWPI) or casein for 11 weeks of a supervised strength-training program.

      Outcomes assessed included body composition (by dual energy x-ray absorptiometry, DEXA), muscular strength (1 repetition maximum, 1RM) and plasma glutamine levels (as a marker of protein synthesis)

      Results: The hWPI group gained more LBM, loss more fat and added more to their 1RM than the casein group. No differences were seen between groups regarding plasma glutamine levels.

      Conclusions And Criticisms: This study suggests that hWPI may confer greater benefits from resistance training programs than the same amount of protein (isonitrogenous) in a different form (casein). However the sample size was very small and thus underpowered to rigorously assess the outcomes discussed above.

      Furthermore the duration of the study was short and thus no comment can be made on long-term benefits of hWPI. Lastly this study did not investigate whether there was an optimal time to consume protein.

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    dot Cribb Et Al 2006 (Timing Of Protein Ingestion: Pre/Post-Workout Or Morning/Evening): dot

      Methods: In this single-blind study, 23 recreational male bodybuilders were matched for strength and then randomly allocated to one of two supplement groups. These two groups consumed 1g/kg/bodyweight of the supplement (40% WPI, 43% glucose, 7% creatine monohydrate and less than 1% fat) either: pre- and post-workout (PRE-POST) or before breakfast and before bed (MOR-EVE).

      Outcomes assessed included body composition, muscular strength and muscle hypertrophy properties (cross-sectional area-CSA, muscle fiber type and contractile protein content).

      Results: The PRE-POST group showed greater improvements in 1RM, LBM, body fat % and markers of muscle hypertrophy (CSA, contractile protein content, type II muscle fiber hypertrophy) than the MOR-EVE group.

      Conclusions And Analysis: Similar criticisms as discussed above apply to this study, i.e. it has a small sample size, was of short duration, etc. How much we can attribute the results of this study purely to WPI is difficult considering other ergogenic supplements such as creatine were given.

      Nevertheless this study clearly demonstrates that despite the individuals consuming their normal diet, there was still a clear difference between groups and a clear effect of supplement timing. Therefore the best time to consume WPI is just before and just after a workout.

    The Best Time To Consume WPI Is Just Before And Just After A Workout.
    Enlarge Click Image To Enlarge.
    The Best Time To Consume WPI Is
    Just Before And Just After A Workout.

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    How Does It Do It?
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    The mechanisms behind whey protein supplementation and protein synthesis are beyond the scope of this article. However, they occur on a variety of cellular and molecular levels. Proposed molecular targets include the mTOR (mammalian target of rapamycin), p70-S6k and pax7 gene.

    There is also evidence that it affects overall balance of protein turnover by manipulating cysteine levels and thus reducing the urea cycle and muscle catabolism.

    Cysteine:
    Cysteine is a non-essential amino acid, which means that it is biosynthesized in humans. Its codons are UGU and UGC. The side chain on cysteine is thiol, which is nonpolar and thus cysteine is usually classified as a hydrophobic amino acid.

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    Factors To Consider
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    A variety of factors may affect the results achieved by taking WPI. These include adjuncts such as creatine monohydrate, carbohydrates (to provide insulin spikes) and blends of different proteins (e.g. WPI with casein).

    Although blunted responses to protein have been associated with increasing age, there is evidence that even elderly individuals may derive benefit from high protein meals/supplements.

    Whey protein may be suitable for all ages and levels of performance status (i.e. recreational, sports athlete, etc). The optimum quantity is about 2 grams per pound of bodyweight.

    dot Health Implications Of Whey Protein Isolate: dot

      Pertaining to those of a high protein dietary intake and will be discussed in a future article. Medical conditions such as kidney problems may preclude the use of protein supplements. It is important to consult your doctor before taking any supplements.

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    Conclusion
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    Protein supplements comprise a large proportion of products in the bodybuilding market. This article has looked at some of the evidence to support its use for recreational bodybuilding purposes.

    However the benefits may not be limited to this group only, and may be of use in a variety of other contexts such as in medical diseases (e.g. wasting states). Nevertheless WPI may offer an efficient and convenient method of improving body composition and performance in resistance training.

      arrow View Whey Protein Products Sorted By Top Seller Here.
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    References:

    1. Boirie Y, Dangin M, Gachon P, Vasson MP, Maubois JL, Beaufrere B. Slow and fast dietary protein differently modulate post-prandial protein accretion. Proc Natl Acad Sci USA (1997); 94(26): 14930-5
    2. Bos C, Gaudichon C, Tome D. Nutritional and physiological criteria in the assessment of milk protein quality for humans. J Am Coll Nutr (2000); 19(2): 191S-205S
    3. Cribb PJ, Williams AD, Hayes A, Carey MF. The effect of whey isolate on strength, body composition and plasma glutamine. Int J Sports Nutr Exerc Metab (2006); 16: 494-509
    4. Cribb PJ, Hayes A. Effect of supplement-timing and resistance training on skeletal muscle hypertrophy. Med Sci Sports Exerc (2006); 38: 1918-1925
    5. Hayes A, Cribbs PJ. Effect of whey protein isolate on strength, body composition and muscle hypertrophy during resistance training. Curr Opin Clin Nutr Metab Care (2008); 11: 40-44
    6. Symons TB, Schutzler SE, Cocke TL, et al. Aging does not impair the anabolic response to a protein-rich meal. Am J Clin Nutr (2007); 86: 451-456