Uncovering Agmatine - What Is It & What Does It Do?

This is the first part of a 3 part series uncovering the novel nutrient Agmatine which will no doubt make some waves in 2007 and beyond. I want to take you inside the benefits of this exciting and essential polyamine. Learn more...
var num=1 var photoslink=new Array() img1 = new Image () img1.src = "images/2007/cns1.jpg" desc1 = " The human central nervous system consists of the brain and spinal cord. These lie in the midline of the body and are protected by the skull and vertebrae respectively.

This collection of billions of neurons is arguably the most complex object known.

The central nervous system along with the peripheral nervous system comprise a primary division of controls that command all physical activities of a human.

Neurons of the central nervous system affect consciousness and mental activity while spinal extensions of central nervous system neuron pathways affect skeletal muscles and organs in the body.


" name1 = " 1 of 3: The Central Nervous System (CNS):" img2 = new Image () img2.src = "images/2007/cns2.jpg" desc2 = " The portion of the central nervous system that is enclosed within the cranium, continuous with the spinal cord, and composed of gray matter and white matter.

It is the primary center for the regulation and control of bodily activities, receiving and interpreting sensory impulses, and transmitting information to the muscles and body organs.

It is also the seat of consciousness, thought, memory, and emotion.

The brain consists of the medulla, the pons, the cerebellum, and the cerebrum, the outer layer of which, the cerebral cortex, is the location of memory, sight, speech, and other higher functions..


" name2 = " 2 of 3: The Central Nervous System : The Brain" img3 = new Image () img3.src = "images/2007/cns3.jpg" desc3 = " The thick column of nerve tissue that extends from the base of the brain about two thirds of the way down the backbone.

As part of the central nervous system, the spinal cord carries impulses back and forth between the brain and other parts of the body through a network of nerves that extend out from it like branches.

Connecting with the cord are 31 pairs of spinal nerves, which feed sensory impulses into the spinal cord, which in turn relays them to the brain.

Conversely, motor impulses generated in the brain are relayed by the spinal cord to the spinal nerves, which pass to muscles. The spinal cord mediates some reflex responses directly.


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1 of 3: The Central Nervous System (CNS):

CNS
The human central nervous system consists of the brain and spinal cord. These lie in the midline of the body and are protected by the skull and vertebrae respectively.

This collection of billions of neurons is arguably the most complex object known.

The central nervous system along with the peripheral nervous system comprise a primary division of controls that command all physical activities of a human.

Neurons of the central nervous system affect consciousness and mental activity while spinal extensions of central nervous system neuron pathways affect skeletal muscles and organs in the body.


Learn More... Back Next

Therefore, maximum tissue delivery of agmatine and its subsequent effects should occur shortly after this 15 minute window. If delivered as a dietary supplement this data set should give manufactures some clue as to the time of consumption for exercise enhancement (again more in-depth info on this to follow in part 3).


Distribution In The Body

So what about the distribution throughout the body?

In a selection of studies the distribution seems to be generally defined in animal species.10-14 The highest concentration of cellular agmatine can be found in the stomach,15 with the aorta and small intestine next followed by smaller levels in the spleen, adrenals, skeletal muscle16 and the brain. 17

Although, you would generally think that the higher the concentration in a metabolite in a specific tissue would indicate the site of greatest effect however it's never as simple as this in reality.

As an example following agmatine administration around 70% is stored in the liver (we will discuss this latter) which may suggest this is a major site of action. Following supplementation it may not be the stomach (highest concentration) but in the liver where the greatest uptake is occurring. Again another interesting indicator we will dig into further as this series of articles progress.


Affects On The Body

How does agmatine affect the body?

As previously discussed agmatine is widely distributed throughout the body and as such it is not surprising that agmatine has been assigned with multiple roles. Which include the following:

  • Insulin enhancer 18
  • Vasodilator 19
  • Memory enhancer 20
  • Inhibits ischemia 21
  • Decreased pain sensation 22
  • Anti-depressant 23
  • Increased epinephrine release 24
  • Modulates NO 25
  • Acts as a neurotransmitter 26
  • Influences GH and IGF-1 27

These are just a selection of actions which may have direct implications to the enhancement of exercise performance and also the adaptive and recovery processes associated with intense exercise. The exciting news is that there is direct evidence for a performance enhancement of exercise performance 28 following agmatine administration which we will cover in the coming parts of this series on agmatine and its supplementation.


Preview

In part II we review the dietary sources of agmatine and ask the question: Are we getting enough? We will also get up close and personal with the actions of agmatine and ask: Are all the listed actions really that proven?

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