Clayton's Health Facts: Hesperidin.

Clayton South, SPN (ISSA), is a recognized expert in the bodybuilding / fitness industry with over 150 bodybuilding, fitness and nutrition publications to his credit.

What Is It?
And Where Does It Come From?

Hesperidin - C28H34O15 - is a water-soluble citrus bioflavonoid found in oranges and lemons. It is highly concentrated in pulp-rich fruit juices.

What Does It Do?
And What Scientific Studies Give Evidence To Support This?

Hesperidin has many health benefits.

Hesperidin exerts vasoprotective effects. In animal trials, hesperidin improved cholesterol profile by elevating HDL (high-density lipoprotein) cholesterol while simultaneously lowering LDL (low-density lipoprotein) cholesterol levels. While human research is required, anecdotal reports suggest a similar benefit on human cholesterol profile.

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In human trials, hesperidin reduced blood pressure values and protected the heart from damage by increasing folate levels and reducing homeocysteine concentrations. In Europe, hesperidin is used to treat vascular disorders like hypertension, and to support capillary health and combat varicose veins.

In addition to protecting the heart and exerting vasoprotective effects, hesperidin has proven anti-cancer abilities. Hesperidin acts as a strong antioxidant and supports cell integrity and immune system health, possibly protecting against many cancers, including colon, skin, urinary and esophageal cancer.1

Hesperidin supports healthy joints and healthy skin. Hesperidin supports healthy joints by working with vitamin C to support collagen formation and collagen structure function. As a result, Hesperidin may improve joint, spine and connective tissue health. Because collagen is the major component of human skin, hesperidin improves skin appearance, tone and elasticity.

Finally, hesperidin speeds exercise recovery by interfering with arachidonic acid metabolism, reducing exercise induced inflammation.2,3

Hesperidin may also mediate the allergic response4 and act as a diuretic.5

Who Needs It?
And What Are Some Symptoms Of Deficiency?

Healthy adults can benefit from hesperidin supplementation (see above).

Hesperidin is not an essential nutrient and no symptoms of deficiency exist. Recommended Daily Allowances (RDA) is not established.

How Much Should Be Taken?
And Are There Any Side Effects?

Use as directed.

Consult a physician before using any dietary supplement.

Hesperidin is safe for human consumption. No side effects are known.

Research suggests that hesperidin may inhibit cellular vitamin C uptake, though more research is needed.

Scientific References:

  1. Berkarda B, Koyuncu H, Soybir GT, Baykut F. Inhibitory effect of hesperidin on tumor initiation and promotion in mouse skin. Res Exp Med. (Berl). 1998; 198:93-99.
  2. Emin JA, Oliveira AB, Lapa AJ. Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids duartin and claussequinone in rats and mice. J Pharm Pharmacol. 1994; 46:118-122.
  3. Galati EM, Monforte MT, Kirjavainen S, et al. Biological effects of hesperidin, a citrus flavonoid (Note I): anti-inflammatory and analgesic activity. Farmaco. 1994; 40:709-712.
  4. Matsuda H, Yano M, Kubo M, et al. Pharmacological study on citrus fruits. II. Anti-allergic effect of fruit of Citrus unshiu MARKOVICH (2). On flavonoid components. Yakugaku Zasshi. 1991; 111:193-198.
  5. Galati EM, Trovato A, Kirjavainen S, et al. Biological effects of hesperidin, a citrus flavonoid. (Note III): antihypertensive and diuretic activity in rat. Farmaco. 1996; 51:219-221.