Applied Bodybuilding Research - 1-02-04

Find out how to increase protein synthesis, all about canabolic steroids, myostatin inhibitors, Ginko Biloba, Colostrum and much more...
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Good news for the aging! Bodybuilding has the answer!

Bodybuilders exercise for a number of reasons. One of these reasons is to increase protein synthesis - ie. gain muscle. Previous research has demonstrated that exercise can improve quality and quantity of life.

Although it is known widely that physical exercise helps to prevent a host of age-related conditions, does it offer any improvement to those who already suffer from such conditions?


A recent study has demonstrated that exercise helps to reverse age-related conditions, by stimulating protein synthesis.

This goes to show that it is never too late to exercise and to lead a healthy lifestyle!

SOURCE: Yarasheski KE. Exercise, aging, and muscle protein metabolism. J Gerontol A Biol Sci Med Sci. 2003 Oct;58(10):M918-22..

Anabolic Steroids: Just a matter of the heart?

Steroids. The one subject always guaranteed to create controversy and dissenting opinions.

It seems that almost anyone you ask will give different viewpoints: steroids are evil, steroids are great, steroids will harm you, steroids are safe. With all of the opinions out there, it is understandable how people can be confused.

A new study, however, has demonstrated that steroids have an impact on heart function. This is not new news by any means, but it confirms previous data. While steroids are not evil, neither are the totally safe.

Use them at your own risk.

SOURCE: Karila TA, Karjalainen JE, Mantysaari MJ, Viitasalo MT, Seppala TA. Anabolic androgenic steroids produce dose-dependant increase in left ventricular mass in power atheletes, and this effect is potentiated by concomitant use of growth hormone. Int J Sports Med. 2003 Jul;24(5):337-43.

Myostatin inhibitors: Does GH make them junk?

It seems that no matter where you look today, myostatin inhibitors are the current bodybuilding buzz.

Myostatin is a compound responsible for limiting muscular hypertrophy, and the idea is that if myostatin can be disabled, muscular growth should proceed without limitations.

The only problem is that myostatin needs to be "turned off" at the genetic level. Naturally, supplement companies have been quick to jump on the sensational hype associated with the idea of unlimited muscle growth. As a result, many ineffective products have been created, and not surprisingly at offensively inflated prices.

One question of interest has been: If bodybuilders can not get myostatin inhibiting drugs because of safety and regulatory concerns, how can they effectively turn off or at least turn down myostatin?

GH may be the answer.

Somatropin, or growth hormone, has been shown in research to inhibit the catabolic effects of myostatin for up to 12 to 18 months after treatment.

Bodybuilders can not get real GH, again because of regulatory concerns, but a wide variety of GH pre-cursors do exist to help in the battle against catabolism. Glutamine, among others, does wonders for GH stimulation.

It seems that the myostatin boom might go bust as soon as real science shines a light upon the matter.

SOURCE: Liu W, Thomas SG, Asa SL, Gonzalez-Cadavid N, Bhasin S, Ezzat S.Myostatin is a skeletal muscle target of growth hormone anabolic action.J Clin Endocrinol Metab. 2003 Nov;88(11):5490-6.

Ginko Biloba: Information you should know!

Ginko Biloba. The name most associated with improved memory and intelligence scores. But ginko biloba also has a number of other health benefits. Among them: it is a powerful antioxidant, it increases blood flow to vital areas of the body, and improves blood-oxygen profile.

New research has demonstrated that Ginko Biloba also has neuroprotective effects.

So aside from making you smarter, Ginko can save your brain from wear and tear.

SOURCE: Ahlemeyer B, Krieglstein J.Neuroprotective effects of Ginkgo biloba extract.Cell Mol Life Sci. 2003 Sep;60(9):1779-92.

Colostrum: Does it work?

For a long time, colostrum has been touted as a "must have" supplement. Some have even gone as far as to call it the "ultimate" supplement. Among its beneficial effects are its ability to destroy infectious bacteria1, to protect the immune system from harmfull viruses2,3,4, and to target certain cancers.5

Certainly colostrum is an impressive supplement with a wide-range of benefits. bodybuilders are always concerned with their hormone profile in general, and hormones like insulin, IGF-1 and GH in particular.

So a question of interest has been: In what way does colostrum impact the hormone profile of a training athlete?

Science has the answer.

A new study done by researchers at the University of South Australia has demonstrated that colostrum supplementation increase anaerobic power, but had no effect on IGF-1 levels.

Source: Buckley JD, Brinkworth GD, Abbott MJ.Effect of bovine colostrum on anaerobic exercise performance and plasma insulin-like growth factor I.J Sports Sci. 2003 Jul;21(7):577-88.

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Copyright © Clayton South, 2003 All rights reserved.

Without limiting the rights under copyright reserved above, no part of this publication may be reproduced, stored in or introduced into a retrieval system, or transmitted in any form, or by any means (electronic mechanical, photocopying, recording, or otherwise), without the prior written permission of the copyright holder and author of this publication.

Additional References

1. Sarker SA, Casswall TH, Mahalanabis D, et al. Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum. Pediatr Infect Dis J 1998;17:1149-54.

2.Majumdar, A. S., et al., Protective properties of anti-cholera antibodies in human colostrum. Infect. Immun. 1982. 36:p. 962965.

3. McClead, R., et al., Resistance of bovine anti-cholera toxin IgG to in vitro and in vivo proteolysis. Pedia. Res. 1982.6: p. 227-231.

4. Lawton, J. W. M., et al., Interferon synthesis by human colostral leukocytes. Arch. Dis. Childhood. 1979. 54: p.127-130.

5. Hakansson et al., Proceedings, Nat. Acad. of Sciences, Vol. 92, pp. 8064-8068, Aug. 1995.