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 By: Joey Rodrigues For the past 11 months, J-Rod and the MANTM Sports R & D team have been enthusiastically at work around the clock on one very special project. While other companies have been busy recycling old ideas and passing them off as new products, The MAN Sports team has hit the supplement Jack-Pot... Big-Time... and in a big way, with its latest addition to its result-drivenTM performance line - CLOUTTM. The mission was simple... to create the mother of all creatine based performance enhancers. But not just any creatine enhancer, this product had to get at the core of increasing explosive muscular fire power and at the same time enhancing recovery and stamina as a way of welcoming athletes to the next level in performance enhancement and body augmenting effects. And so project CLOUT was born. As you will soon learn, CLOUT is the end result of real scientific data with proven efficacy in the lab and the gym! The precise balance of vision, passion, science and innovation is the driving force behind its creation. With its use, ANYTHING IS POSSIBLE. Let us explain! The wait for a proven multi-component performance enhancer is over! What you are about to witness is one of the only supplements available anywhere, where every single ingredient is proven to extend your performance and recovery from intense exercise.
To put this in perspective, CLOUT is comprised of 7 powerful, never-before combined bioactives to create a new and exciting direction in supplementation, maximizing human performance, body composition and optimizing athleticism. This very one product supports 5 very powerful biochemical and physiological effects, distinguishing it from existing run-of-the-mill creatine matrixes and effectively taking the science and effectiveness of performance and body augmenting supplementation to the FRONTIER. I know it must be hard for many of you reading this to believe these words, and frankly I don't blame you. You have heard it all before. But do yourself a favor and keep reading; we are going to prove that our smack is more than the typical supplement company hype.
CLOUT introduces 2 exclusive new break-throughs in the enhancement of muscle performance. First a NEW ingredient for carnosine enhancement and secondly acetyl group donation, a process directly linked to ATP resynthesis and energy generation (we will go into detail on this soon). You have read correctly, that is 2 NEW breakthroughs in performance.
To understand how stratospheric these breakthroughs are, you need to understand the influence of carnosine. Its many positive effects are beyond the scope of this one article; however know that carnosine is the ultimate buffering agent. And what that means to you is a effective weapon to fight off that nasty burning sensation during intense exercise. Carnosine also helps your muscles contract harder and longer. In fact, no other nutrient is as powerful as carnosine when it comes to these specific functions. So what exactly is inside scoop on the 7 never before combined bioactives? What do the geeky guys and gals in the white lab coats say? And just what's the best way to use CLOUT as part of your daily dietary routine in your quest to be the best? How do the specific uses of 3 nutrients enhance your muscles phosphocreatine stores and ATP generating capacity above and beyond anything you have ever tried before? To answer all the questions, we need to get down to the 5 specific mechanisms that drive CLOUT's positive properties. So, before we get to the core of the ingredients that make CLOUT, let's look at some of the major influences behind fatigue in order to understand the premise behind each nutrient in CLOUT.
During periods of high intensity exercise, very much like sprinting or banging the iron around in the gym with major intensity, your working muscle tissues increase the production and utilization of high-energy substrates (Such as ATP). This results in major hydrogen ion (H+) production. The increased energy demand during exercise and ensuing increases in H+ ion generation can lower pH, see (Metzger and Fitz 1987)[1]. So what does this mean to you, the athlete or the weekend warrior? Low pH values inhibit the ability of muscle to contract efficiently; (again for you science guys) see (Metzger and Fitz 1987) [1] and thus the ability to produce force (Cooke and Pate 1985) [2].
If you're involved in resistance training or sprint type exercise it goes without saying how damaging this can be on performance. If only we could fight the negative decline in exercise performance, better training sessions and athletic performance could be the reality! Well, the primary mechanism controlling acidity levels in human skeletal muscle has been shown to be reliant upon several independent buffering mechanisms, mechanisms which operate synergistically to maintain H+ ion status and thus pH (Parkhouse and McKenzie 1984) [3]. A simple way to think of this is to imagine H+ as fire and buffers as the extinguishers. Total Intra-cellular (Within Muscle) H+ Ion Buffering Can Be Subdivided Into Three Major Components:
Therefore, elevating the capacity of any of these systems should significantly delay the onset of declining pH related fatigue. CLOUT does that!
In order for best possible muscle contractile responses to be maintained, ATP resynthesis from ADP (a lower energy producing compound than ATP) must be met by oxygen-dependent and oxygen-independent pathways. Interesting, but what does it mean? And where is the biochemical defect in this system that can be manipulated to enhance your performance capacity? Here is what science says. Oxygen-dependent ATP re-synthesis (Aerobic glycolysis) does not increase instantaneously at the onset of exercise. And because of this, a greater reliance is placed on the oxygen-independent (phosphocreatine and anaerobic glycolysis) pathways of energy production.
 Click To Enlarge.Knowing how energy metabolism works, a series of investigative studies has shown that this LAG-PHASE in oxygen-dependent ATP production is due to an "Acetyl Group Deficit" (fatty acid). These acetyl groups are formed originally from an enzyme system in our muscles (see figure 1) called the 'pyruvate dehydrogenase complex' (PDC). Therefore, any way to provide an increase of acetyl groups at rest or more beneficially pre-exercise should decrease initial falls in muscle phosphocreatine contents and under some circumstances improvement in contractile function [4]. And that is exactly what CLOUT does... take a look!
Phosphocreatine (PCr) is a system that maintains ATP levels during short duration and high intensity exercise by donating a phosphate group (ATP -> ADP + PCr = ATP + Cr).
 Research has shown depletion of phosphate and phosphocreatine decreases exercise performance and leads to fatigue. Based on work by Febbraio and Dancey (1999) [5] which many of you will be familiar with clearly showed elevating muscle creatine stores enhances muscle performance.
Increased oxygen (O2) consumption which occurs during moderate and intense exercise releases potential harmful oxygen byproducts known as free radicals. This oxidative stress can cause damage to cell membranes and important enzyme systems.
A selection of nutrients stored in our bodies known as Antioxidants have been shown to fight these detrimental influences of free-radicals. The most abundant and powerful antioxidants in skeletal muscle is glutathione and by maintaining and/or elevating this antioxidant enhancement of sprint capacity and other intense exercises.
Muscle strength and protein synthesis have been correlated to the status of the mineral magnesium [6]. Other functions include membrane stability, energy transfer and a direct effect on muscle calcium levels [7, 8]. As you can see, magnesium is a vital nutrient, so it may come to you as a major surprise to learn that this important mineral is deficient in 75% of the population [9], with 39% taking in less than 70% of the RDA [9].
You Read Correctly! In the athletic world several studies have shown that higher levels of sweat and urine loss from intense exercise greatly increase magnesium deficiencies. In order for you to be your best and prevent a decrease in performance adequate intakes of magnesium are VITAL! OK, so now you have somewhat of a fundamental knowledge of the 5 primary mechanisms in which CLOUT delivers the goods! You understand now what causes fatigue and holds back your ability to be stronger and, have more energy to keep going. It is now time to get to the nuts & bolts of CLOUT - its CORE - the 7 never before combined bioactives. Let's reveal how we have hit the performance enhancing JACK-POT, in a BIG-WAY!
What Is It?
Orotic Acid (OA) is bond to creatine and also supplied to exactly match orotic acid doses in human studies shown to enhance performance [10]. So why do creatine and OA work so well together? And how do they work in synergy?
How Does It Work?
Think FIRE-EXTINGUISHER. Two central components of these systems are phosphocreatine and carnosine. True to form CLOUT yet again delivers the exact dose of creatine shown to elevate muscle phosphocreatine levels. CLOUT Also Provides The Exact Level Of OA Shown To Work Effectively On Two Levels: That is impressive... but don't get it twisted were not done!
What Evidence For Performance Effect?
Performance was enhanced with supplementation but backing up the influence of orotate rather than magnesium was the measured lower hydrogen ion levels. This is suggestive of enhanced buffering capacity via orotate by elevated muscle carnosine contents. Therefore, these two ingredients may set off each others functions in many ways. Orotic Acid and creatine both enhance your muscles buffering capacity, literally putting out the fire. As an added bonus orotic acid may help preserve creatine levels during intense hypoxic (lacking oxygen) exercise [12]. Additionally both compounds support growth and recovery. So the combination of Orotic Acid and Creatine, as found in OROTINETM truly makes them a powerful 1 - 2 punch for those seeking to build mass.
What Is It?
As previously mentioned, CLOUT has placed in the exact amounts of each ingredient proven by research to enhance performance and the content of Beta-alanine is no different.
How Does It Work?
What Evidance For Performance Effect?
The dose of beta-alanine delivered in CLOUT enhanced maximal workout puts over a 4 minute maximal exercise test. Again authors suggested these beneficial performance effects down to increased muscle buffering capacity which aids the maintenance of muscle pH.
What Is It?
How Does It Work?
Secondly, it can also provide acetyl groups which could be used for entry into the Krebs cycle and energy generation overcoming deficiencies in the PDH complex.
 Click To Enlarge.
What Evidence For Performance Effect?
CLOUT delivers probably the highest amounts of NAC in any sports supplement many times above the cysteine and acetyl groups delivered in these studies! OK back to the outcome of the Sen Study, NAC resulted in a higher net post exercise antioxidant capacity [16]. But can elevating oxidative capacity through cysteine donation influence performance? The answer is simply YES! A study presented at the ACSM on whey protein delivering similar cysteine levels to those in CLOUT improved muscle fatigue during fatiguing leg extension exercise [17].
What Is It?
Changes in cellular phosphate levels have been linked to enhanced exercise capacity time and time again. Supplementation is a proven method to achieve this guaranteed performance effect.
How Does It Work?
Therefore, it is easy to see how phosphate addition can further extend the influence of CLOUT as the ultimate creatine and performance enhancer.
What Evidence For Performance Effect?
The results backed many other studies and showed that phosphate loading could enhance maximal exercise performance (40km time trial). The slightly lower dose of phosphate in CLOUT compared to the study above were chosen because of not only the gastrointestinal stress caused by high dose phosphate but also because the creatine and phosphate combination included in CLOUT should enhance muscle phosphate to equal and possibly greater levels than phosphates alone. (Check out our how to use guide here).
What Is It?
How Does It Work?
What Evidence For Performance Effect?
In a study by Tohgi et al. subjects were given 15mg of Vinpocetine per day (a dose lower than that contained in CLOUT) for 3 weeks [24]. By the end of the supplementation period there were huge increases in cellular ATP as well as an increase in 2, 3 DPG [24].
What Is It?
As such the importance of magnesium as a performance enhance cannot be denied. Magnesium-Malate supplies extra malic acid, which has been shown to recycle pyruvate and lactate and help to fuel the Kreb cycle (our natural energy producing cycle) [29].
How Does It Work?
What Evidence For Performance Effect?
Smack it up, flit-it and rub-it down! The take home message on Clout!
At MAN Sports we believe anything is possible. Within this state of mind, unbelievable innovations are dreamt and brought to reality. CLOUT has shattered old world beliefs, defying existing barriers and obstacles effortlessly, bringing to the market state of the art strength, stamina and recovery supplementation. This work, this Holy Grail, is the result of the perfected balance of vision, passion, science, innovation and technology. Not only is its make-up completely supported by genuine clinical studies, but it has also been in the trenches, tested, and tested again by real world athletes. Simply put, CLOUT delivers BIG-TIME! CLOUT is one of the first of a new generation of supplements that can be effective for both resistance and endurance exercise. The ability to enhance sprint and muscular endurance capacity simultaneously helps you work longer for harder leading to greater gains from your exercise performance. Because, we have enhanced your ability to work we have also enhanced you muscles capacity to recover by inhibiting the accumulation of excess free radicals. That means greater performance, more muscle, better health and real power you can feel and harness!
Refences
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