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As anyone who has ever dieted for an extended period of time can tell you, the hardest part about dieting is controlling your appetite. There are products on the market today that aim to decrease appetite, such as hoodia, but, for most, these simply do not work well enough. Losing weight is governed by calories in vs. calories out. If you eat more calories than you burn, you are not going to lose weight. In addition to controlling one's appetite, bodybuilders and fitness enthusiasts must worry about preserving muscle tissue and losing only fat. Nobody wants to work hard to gain muscle only to lose it when dieting to lose weight.
After extensive research, SciVation has created LipidFX™ a supplement that activates PPARalpha, causing an increase in fat oxidation, along with decreasing appetite and improving insulin sensitivity. LipidFX™ is comprised of three fatty acids:
SciVation LipidFX™ is a precise, scientifically advanced blend of Lipolytic Lipids™. Lipolytic Lipids™ are fatty acids that can increase metabolic rate, significantly support appetite control and immune health, help support healthy lipid profiles and insulin levels and promote optimal cardiovascular health. LipidFX™ can also help the body burn fat instead of muscle while in a calorie-deficient state. Here is why LipidFX™ is perhaps the biggest breakthrough in healthy fat loss to date!
The Peroxisome Proliferator-Activated Receptors (PPAR) receptor family is divided into three subgroups: alpha, delta/beta, and gamma. PPARalpha is highly expressed in muscle, the liver, kidneys, and heart and is involved in the regulation of lipid metabolism, specifically the transcription of the genes involved in the beta-oxidation (burning) of fatty acids and lipogenesis (storage of fatty acids). Fat can be oxidized in the mitochondria and the peroxisomes of cells, the majority of this oxidation occurring in skeletal muscle cells and the liver. PPARalpha activation increases fat oxidation in mitochondria and peroxisomes by increasing the expression of enzymes involved in beta-oxidation of fatty acids.6
In addition to this, PPARalpha activation increases the number of both peroxisomes and mitochondria. The combination of the increased number of peroxisomes and mitochondria plus the elevation in beta-oxidation of fatty acids increases the rate and capacity at which fat can be burned. The end result is more fat loss. Activation of PPARalpha would be very beneficial for any bodybuilder or fitness enthusiast looking to lose fat or watch their weight.
Oleoylethanolamide (OEA) is synthesized in the intestines. Its synthesis is increased with food intake and decreased with fasting. OEA has been shown to have anorexic properties, meaning it decreases food intake. 
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OEA is also an activator of the Peroxisome Proliferator-Activator Receptor Alpha (PPARalpha).2 Activation of PPARalpha by OEA will cause an increase in fat oxidation along with a decrease in fat storage, creating an ideal environment for fat loss.
OEA's ability to decrease appetite and regulate body weight is accomplished by the activation of PPARalpha.5 Standard OEA has very poor bioavailability so SciVation uses Phospholean, a form of OEA that is protected from destruction in the stomach. Green tea extract (EGCG) has been a popular supplement for a while, but more and more research is confirming not only its many health benefits, but its ability to promote fat loss. In addition to multiple animal studies showing green tea to lead to fat loss published just this year, a three month double-blind, placebo controlled study on thirty men was published in the January 2005 issue of the American Journal of Clinical Nutrition. Compared to the placebo group, those who ingested catechins (the beneficial compounds in green tea that extracts are standardized for) daily lost more weight and more fat. While the earlier research was more preliminary, this study confirms the ability of green tea to lead to fat loss in humans.
Recent research has also given us a better picture of how green tea leads to fat loss. The more well-known mechanisms are catechol-O-methyl-transferase (COMT) inhibition, decreased dietary fat absorption, and increased levels of some hormones that suppress the appetite. A study published last year suggested yet another mechanism: when given to rats, green tea decreased the activity of glucose transporter 4 (GLUT4) in fat tissue, while increasing GLUT4 activity in muscle tissue. What this means is that fuel was being shunted away from fat and towards muscle. Not only does green tea facilitate weight loss, it can also lead to the preferential loss of fat over muscle. This is a great asset, since maintaining muscle mass is one of the hardest things to do on a diet. A new study has discovered the phytochemicals in green tea are better used by the body in supplemental form rather than from actual green tea. The main catechin responsible for the thermogenic effect of green tea extract is epigallocatechin gallate (EGCG). Studies show it can increase metabolism by about 4%. That equates to more than 100 extra calories burned per day for most males. EGCG inhibits the enzyme responsible for the degradation of NE (NorEpinephrine). By preventing NE breakdown, its fat burning effect is stronger and lasts longer.
Stearoylethanolamide (SEA) has been shown to decrease food intake independent of PPAR and without changing hematochemical parameters such as glucose and triglyceride levels or leptin (a hormone involved with satiety) expression.3 The appetite decreasing effect of SEA was associated with a reduction in liver stearoyl-CoA desaturase-1 (SCD-1) mRNA expression. SCD-1 is the rate-limiting enzyme in the biosynthesis of monounsaturated fats and its reduction is believed to lead to increased fatty acid oxidation and decreased lipogenesis in skeletal muscle and the liver.4
TetradecylThioacetic Acid (TTA) is another PPARalpha activator.7 TTA works in conjunction with OEA in increasing the oxidation of fatty acids and decreasing the storage of fatty acids. TTA has been shown to increase insulin sensitivity by increasing hepatic fat oxidation and ketogenesis while draining fatty acids from the blood and extrahepatic tissues. Increased insulin sensitivity means less insulin needs to be secreted to accomplish a given task. This is beneficial while dieting because insulin is anti-lipolytic.
If you're interested in not only optimizing your health but also decreasing appetite and enhancing fat loss all while preserving precious lean muscle, LipidFX™ is the perfect supplement for you! References:
Objective = Fat Loss 
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SamoanGirl: Before And After. Thoughts: The side effects I have found would be that at first after you take it you do get a little lightheaded, and sleepy, but I have found out that you must eat several small meals in order to keep energy levels balanced. And I mean healthy foods not junk. Oh yeah, and you do get a bit irritable - but you just have to control that."
Starting Weight = 196 lbs 
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Scheizekopf: Before And After. Thoughts: The major side effect of LipidFX for me was the appetite suppression, which I loved by the way. It was noticeably quicker than everybody expected. I didn't have any of the sides like headaches or being irritable like the other testers reported. I did experience some water retention like the others and my lower stomach stuck out an extra inch or two at different times of the day (mostly at night). Overall I definitely liked this product and would recommend it to people cutting or bulking and I will also purchase it sometime in the future for another go at it.
Objective = Clean Bulk Thoughts:
Objective = Clean Bulk Thoughts: The TTA burns your body's glucose at a rapid rate. The most amazing aspect I found from LipidFx was the ability for me to consistently eat 1,100 calories over my maintenance with almost no cardio for over 30 days now, and I have not gained any weight. It seems I actually winded up losing a couple of pounds. Just unbelievable. I also got stronger in the gym and better muscle endurance with the increase in calories in all my exercises. Amazing!!! The appetite suppression did not affect me, however it may for others."
Objective = Fat Loss Positives: Negatives: "All in all I think this was a great product, and I've never tried sesamin before so I think I shall try that along with this product. I think next time I try LipidFX I'm gonna up the dose to 5 or 6 and see how that plays out."
Objective = Bulking Thoughts: In terms of fat loss, that is where I would like to state that I was on cycle, bulking (~4000-4500 calories), not doing much/intense cardio and supplementing with other products. I was not concerned in losing fat or overall losing a few points in bodyfat, but rather interested in not gaining unwanted fat gains. And to my expectations, LipidFX met that goal.
There was one side effect that existed and was a pain in the *ss, or should I say, a pain in the belly. It was a very strong and disturbing bloat on my belly/abdomen area. I felt "big" all the time, and not the big/swole feeling kind. At first, the bloat initiated in my face and abdomen, then it ceased from my face, but continued on my mid and lower belly. It was quite a bother, but very tolerable. About 24 hours after my last dose, it seems to be decreasing.
Objective = Fat Loss Thoughts:
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I decided to do the LipidFX™ all by itself in order to give it a fair trial without interference from other factors/supplements. My diet and cardio stayed along the same routines for the most part for the same reasons. I had not heard any hype or build-up for this product before starting it, and actually had to read up on what it actually was. I knew I believed in and liked SciVation's products and was excited to try another one. The Results: This product is what it is, and gave the results to back it up: An effective appetite-suppressant that aids fat loss and will work excellently as part of a stack. All alone, even for someone who had already been cutting, I lost ~2.5 pounds per week, which most consider ideal. The product was most effective in my opinion as an appetite suppressant. I noticed that effect within the first 3-4 days of using the product, as I logged. This effect strengthened a bit and remained consistent throughout the log. In my experience, this product works from the very beginning to the very end of the bottle, which is something many products cannot say. It did not take weeks to "kick in", but was almost immediately noticeable. As I said, this product is effective on it's own, however in my opinion would work most effectively if used along with some other supplements such as thermogenics, etc."
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Two major organelles of the human cell.
A study done on rats showed that OEA's ability to decrease appetite did not change plasma levels of various intestinal hormones involved in satiety, such as ghrelin and CCK, showing OEA works independently of these hormones.1
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