Weight Loss Using 7-Keto DHEA
It isn't often that a product ingredient can grab headlines in a 24-hour news cycle jammed with a presidential campaign and Lin-sanity, but 7-Keto has gained major media attention in recent days. No wonder: Dr. Oz mentioned it on his show on February 20th, and the Wizard of Oz seems to have a magic touch when it comes to generating interest in health products and topics.
Want to learn more about this ingredient? The following Q&A may answer at least some of your questions:
If overweight, you're more likely to develop heart disease, high blood pressure, diabetes, certain types of cancer, gout, and gallbladder disease than people of normal weight. Being overweight also can cause problems such as sleep apnea (interrupted breathing during sleep), infertility in women, and osteoarthritis.9-11
The more overweight you are, the more likely you are to have health problems. Of the 61% overweight Americans, half are termed obese. Obesity is a serious and disabling chronic disease.2
Simply stated, obesity is excessive fatness. One of the most accurate methods of determining obesity is to calculate body mass index (BMI). BMI takes into account a person's weight and height to gauge total body fat in adults. A BMI of 25 to 29.9 is considered overweight, a condition that carries moderate health risks. A BMI of 30 or higher is considered obese.9 (Click here for a BMI chart.)
The list of excess weight implications on human health is long and the impact is sobering. The risk of Type II diabetes increases dramatically in overweight and obese individuals. 12 Diabetes is the leading risk factor in heart disease and stroke, the leading cause of blindness and kidney disease, and a major contributor to leg amputations.13
Obesity also has serious effects on the heart and blood vessels. It causes the heart to work harder and, over time, can lead to enlargement and heart failure.14
Cancer also has been linked to weight gain. Overweight and obese individuals have a higher incidence of rectal, colon, kidney, prostate, breast, ovarian and uterine cancers. Researchers have determined excess fat changes metabolism in a way that increases abnormal cell growth in these organs.15
Being overweight also causes mechanical problems. Osteoarthritis is present in many overweight and nearly all obese individuals.16 Obese individuals also are at increased risk of developing gouty arthritis, a distressingly painful disorder.17
Some medications are attracted to fat tissue and administration of these drugs in obese persons may present complications. Anesthetic agents given during surgery can be dangerous for overweight and obese individuals. Wound healing is much slower and more difficult when it involves fatty tissue.10
Obesity also is the second leading preventable cause of death in the U. S. after cigarette smoking.2 The greater the degree an individual is overweight, the higher his/ her mortality ratio or excess death rate. In a recent study published in the Journal of the American Medical Association, death rates for individuals ages 18-to-29 years with a BMI of 40 or higher was 422% higher for men and 379% higher for women than individuals with normal BMIs.18
In many European countries, there are fewer overweight and few obese individuals. Europeans have access to and tend to eat a variety of healthful foods. In the Mediterranean, people eat an abundance of fruits, vegetables, fresh fish, lean meats and olive oil. Studies have shown this diet can result in a long, healthy life.19 For example, while the traditional French diet includes high-calorie, high-fat foods, the average French citizen is of normal body weight.
Smaller-size portions are the norm for French dining.20 Americans, on the other hand, love to "super-size" meals. We also are extremely busy; eating on the run from fast food restaurants is a way of life for many families. Once we are home, we often watch TV and snack on high-calorie, highly processed foods. This sedentary activity adds to our weight woes. American obesity seems to be a grim consequence of western affluence and overconsumption.21
The causes of being overweight and obese are not easily explained. Excessive food intake is not the only factor to blame. As we age, we also experience changes in energy expenditure and metabolism; both of these contribute to fat storage and obesity.
We now know the body has a complex, highly-sophisticated system for fat store regulation. When overweight individuals change their eating habits and lose weight, their bodies want to maintain fat stores and try to minimize the discrepancy. This is commonly referred to as the "set point" for body fat.22
The set point theory states an individual's metabolism will adjust itself to maintain a weight at which it's comfortable. If calories are restricted, our metabolic rate falls in an attempt to preserve our fat stores. This is nature's way of preventing starvation. Once weight is lost and calories are no longer restricted, the metabolic rate rises once more. Many studies have sought to evaluate if the set point can be altered, and some have gone as far as clinically monitoring the caloric intake and exercise of candidates to find that most overweight individuals can't lose weight permanently.23,24
Scientists who study obesity recognize losing excess weight is difficult. Indeed, as many as 95% of dieters gain back unwanted weight, getting caught in endless cycles of yo-yo dieting.1
Researchers have concluded the human body has a genetically determined set-point weight that's controlled by metabolic hormones and fat cell enzymes.3
Yes. In recent studies 7-keto increased the activity of enzymes associated with metabolism.5,6 About 60% to 75% of our total energy needs are met through our basal or resting metabolic rate. 25 Even a minor shift in this rate may have a dramatic impact on calories burned.
7-keto is a safe DHEA metabolite and has been the subject of research and clinical study. Researchers believe 7-keto, like DHEA, plays a role in many body functions, including immune response, memory, skin integrity, and weight management.4-8
Interest in the possible role of DHEA and its derivatives (e. g., 7-keto) in body weight regulation dates back more than 30 years. In some experiments, DHEA caused laboratory animals to eat more, yet suppressed their weight gain.26 In one study without DHEA, a 50% reduction in food intake was necessary to achieve the same degree of body weight changes seen in the rats that were given DHEA but didn't change their food intake.27
Unfortunately, DHEA's conversion to the sex hormones has been a cause for concern. Elevated DHEA levels can cause a build-up of testosterone and estrogen in men and women, increasing their risk for reproductive cancers, such breast and prostate cancers.5
Yes. Based on the work of Dr. Henry Lardy of the University of Wisconsin Department of Biochemistry, we know 7-keto offers many of DHEA's benefits without conversion into the sex hormones estrogen and testosterone. As for weight loss, Dr. Lardy's research shows 7-keto is even more potent than DHEA for stimu-lating enzymes in the liver responsible for thermogenesis (burning calories).5-8 Dr. Lardy was awarded a U.S. patent on 7-keto as a method for promoting weight control by treating a subject without affecting appetite or inducing the synthesis of sex hormones.28
In recent studies, 7-keto increased the activity of enzymes associated with metabolism. Even a minor shift in this rate may have a dramatic impact on calories burned.
7-keto jump starts weight loss, making the hard work of dieting and exercise a little easier by boosting metabolism and lowering the body weight set point.2
A clinical trial, designed to evaluate 7-keto's effect on weight loss in healthy human subjects, was conducted by an independent clinical research group.4 Two groups of 15 subjects, average age of 44.5 years, were given either 7-keto or a placebo. Participants exercised three times a week for 45 minutes per session. Each subject was assigned an 1,800-calorie diet. Each subject in the treatment group received 100 mg of 7-keto twice daily.
Study results at four and eight weeks indicated a statistically significant decrease in body weight and body fat in the 7-keto group and no similar effect in the placebo group. By the eighth week, the group receiving 7-keto lost an average of 6.34 pounds and experienced a 1.8% drop in body fat percentage.
Not only was this significantly greater than the placebo group, but these results were equal to or greater than those obtained from many other so-called natural and medical weight loss remedies. Equally important, 7-keto was well tolerated. While the participants who used 7-keto experienced a statistically significant increase in T3 thyroid hormone activity, there was no effect on T3 thyroid hormone in the placebo group. Additionally, T3 was not increased outside of acceptable normal ranges.
The T3 thyroid hormone is a potent metabolic stimulator. This degree of elevation probably increased the metabolic rate of these subjects. It should be noted this significant yet safe increase in T3 activity is one of the reasons people using 7-keto lost weight. Their metabolism and set point had been reset at a higher rate.
There are no magic bullets in weight loss. 7-keto cannot produce weight loss without a healthful diet and regular exercise. However, 7-keto jump starts weight loss, making the hard work of dieting and exercise a little easier by boosting metabolism and lowering the body weight set point.
Participants in the weight-loss study took 100 mg of 7-keto twice daily. Both experimental and clinical trials indicate 7-keto is safe for long-term use. Toxicology studies using 7-keto found no adverse effects even in doses that would equal 140,000 mg in an average-sized adult. Blood chemistry and liver function remained normal.7,8
What's more, 7-keto's impact on T3 thyroid hormone facilitates a shift in one's weight set point, helping to keep pounds off now and in the future.4-6 After individuals lose weight, they can reduce the amount of 7-keto used, or rely upon regular exercise to support increased metabolism. If body weight begins to increase, 7-keto can be used again as needed to support metabolic rate.
Americans like immediate results. Instant weight loss, for now, is an impossibility. But what is possible, however, is a steady and successful weight loss program. Even weight losses of 10-or-20 pounds can be extremely beneficial for our health.29 To accomplish this, however, we need to make some changes. We need to choose from the abundant supply of nutritious foods to make our daily meals; walk, bike, jog, or participate in another aerobic activity at least five times a week; drink at least 64 ounces of water every day; and commit to a more healthful lifestyle. Using 7-keto as a dietary supplement to boost our metabolism and lower our set point is such an affirmation.
This Body Mass Index (BMI) chart allows men and women to determine their BMI based on their height and weight. For example, a woman who is 5-foot-5 and weighs 126 pounds has a BMI of 21. The chart also indicates which BMIs indicate a minimal, low, moderate or high risk of excessive fatness and the associated health risks.
About The Doctor
Dr. Marcus Laux is a licensed naturopathic physician. He received his doctorate from the National College of Naturopathic Medicine (NCNM) in Portland, where he currently serves on staff as a clinical professor. Dr. Laux is the co-author of "Natural Woman, Natural Menopause" (Harper Collins, 1997), a complete plan for staying naturally well through menopause and beyond. He has been seen by millions on his network television series "The Natural Health Show" in Europe, "Wellness Watch," a daily news segment in Canada, and currently on Fox News' "MD TV" in the United States.
- National Institutes of Health. Weight Control Information Network. Available at: www. niddk. nih. gov/ health/ nutrit/ pubs/ health. htm. Accessed on May 30, 2001.
- National Center for Health Statistics. Prevalence of overweight and obesity among adults: United States, 1999. Available at: www. cdc. gov/ nchs/ products/ pubs/ pubd/ hestats/ obese/ obse99. htm. Accessed June 5, 2001.
- Pi-Sunyer FX. The fattening of America. JAMA. 1994; 272: 238-239.
- Colker CM, Torina GC, Swain MA, et al. Double-blind study evaluating the effects of exercise plus 3-acetyl-7-oxo-dehydroepiandrosterone on body composition and the endocrine system in overweight adults. J Exerc Physiol (online). 1999; 2: 1-2. Available at: www. css. edu/ users/ tboone2/ asep/ abstractROB. html.
- Lardy H, Kneer N, Wei Y, Partridge B, Marwah P. Ergosteroids. II: Biologically active metabolites and synthetic derivatives of dehydroepiandrosterone. Steroids. 1998; 63: 158-165.
- Lardy H, Partridge B, Kneer N et al. Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone. Proc Natl Acad Sci USA. 1995; 92: 6617-6619.
- Lardy H, Kneer N, Bellei M, Bobyleva V. Induction of thermogenic enzymes by DHEA and its metabolites. Ann N Y Acad Sci. 1995; 774: 171-179.
- Davidson M, Marwah A, Sawchuk RJ, et al. Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers. Clin Invest Med. 2000; 23: 300-310.
- Obesity and physical health. In: Grodner M, Anderson SL, DeYoung S. Foundations and Clinical Applications of Nutrition: A Nursing Approach. St. Louis, Mo: Mosby; 2000: 284-287.
- Pleuss J. Overnutrition and obesity. In: Porth CM. Pathophysiology: Concepts of Altered Health States. 5th ed. Philadelphia, Pa: Lippincott; 1998: 1254-1258.
- Obesity. In: Guyton AC, Hall JE. Textbook of Medical Physiology. Philadelphia, Pa: W. B. Saunders Company; 1998: 893-894.
- American Diabetes Association. What is type II diabetes? Available at: navigation. helper. realnames. com/ framer/ 1/ 112/ default. asp? realname= American+ Diabetes +Association. Accessed: June 6, 2001.
- Guven S, Kuenzi J. Diabetes mellitus. In: Porth CM. Pathophysiology: Concepts of Altered Health States. 5th ed. Philadelphia, Pa: Lippincott; 1998: 805.
- American Heart Association. Questions and answers about obesity. Available at: women. americanheart. org/ self_ care/ fs_ reduce_ risk2. html. Accessed June 6, 2001.
- American Cancer Society. The importance of nutrition in cancer prevention. Available at: www2. cancer. org/ prevention/ NutritionandPrevention. cfm. Accessed June 6, 2001.
- Sturmer T, Gunther KP, Brenner H. Obesity, overweight and patterns of osteoarthritis: the Ulm Osteoarthritis Study. J Clin Epidemiol. 2000; 53: 307-313.
- Takahashi S, Moriwaki Y, Tsutsumi Z, Yamakita J, Yamamoto T, Hada T. Increased visceral fat accumulation further aggravates the risks of insulin resistance in gout. Metabolism. 2001; 50: 393-398.
- Bender R, J?l KH, Trautner C, Spraul M, Berger M. Effect of age on excess mortality in obesity. JAMA. 1999; 281: 1498-1504.
- Weisburger JH. Eat to live, not live to eat. Nutrition. 2000; 16: 767-773.
- Volatier JL, Verger P. Recent national French food and nutrient intake data. Br J Nutr 1999; 81( Suppl) 2: S57-S59
- Krauss RM, Eckel RH, Howard B, et al.. Revision 2000: a statement for healthcare professionals from the Nutrition Committee of the American Heart Association. J Nutr. 2001; 131: 132-146.
- Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med. 1995; 332: 621-628.
- Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 1997; 387: 903-908.
- Heymsfeld SB, Greenburg AS, Fujioka K, et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA. 1999; 282: 1568-1575.
- Components of total energy expenditure. In: Grodner M, Anderson SL, DeYoung S. Foundations and Clinical Applications of Nutrition: A Nursing Approach. St. Louis, Mo: Mosby; 2000: 254-255.
- Schwartz AG, Pashko LL. Cancer chemoprevention with the adrenocortical steroid dehydroepiandrosterone and structural analogs. J Cell Biochem Suppl. 1993; 17: 73-79.
- Cleary MP, Zisk JF. Anti-obesity effect of two different levels of dehydroepiandro-sterone in lean and obese middle-aged female Zucker rats. Int J Obes. 1986; 10: 193-204.
- United States patents for 7-Keto DHEA. Patent number 5,296,481, May 22, 1994; 5,424,463, June 13, 1995.
- Williamson DF, Thompson TJ, Thun M, Flanders D, Pamuk E, Byers T. Intentional weight loss and mortality among overweight individuals with diabetes. Diabetes Care. 2000; 23: 1499-1504.
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How can you claim that results in treatment group were significantly larger than placebo group, without releasing the results in the placebo group? Please post the numbers and let the readers make an informed decision on a product rather than posting an advertisement.
lol @ BMI graph. The BMI scale may apply to someone who never exercises but if you have any muscle mass its gonna put you in the moderate to high risk range unless your super lean. C'Mon BB
That is a known, industry-recognized limitation of the Body Mass Index:
But BMI is still useful for most people, and is still widely used in the health care industry.
also even if you are in shape with a lot of muscle, there are still risks associated with a high bmi due to muscle mass instead of fat as the muscle takes up space in the body obviously and excessive muscle cramps the heart and lungs which may cause troubles just like fat would but to a lesser extent.
@awlareau so what source do you base this information on? muscles cramping lungs and heart? the amount of skeletal muscle needed to put pressure on the heart or lungs would be astrological at best...and bmi has no basis to scale a resistance trained person.
Honestly most americans are overweight or obese beause they're lazy and simply want an easy way out and aren't willing to really take action.I understand that there are people that have conditions that hinder or make it close to impossible to lose weight, but with moderate exercise (i.e. Walking, running,cycling) and eating moderatly healthy i'm guessing that the obesity number would be incredibly lower
7 keto may or may not help but at the end of the day hard work and committment is the only real way to achieve goals. I use to be overweight but i made a committment and have changed my lifestyle. That's the best way to lose weight.
I don't believe in the set point or any other theory that says fat is inherited, I believe we learn habits good or bad from our familys. I was adopted, all of my biological family would fall in the obese catagory, none of my adopted family would. I would also like to see more studies done before a conclusion to a drug is reached.
This is why it will be in the new CLK product by Cellucor. People need a non-stimulant weightloss aid sometimes, and between CLA and 7-keto to start....its a great way to cycle off stims, and keep weightloss going.