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4 Ways Beta-Alanine Supplementation Can Buffer Muscle Fatigue!

Do you wonder what makes your muscles fatigue during your workout? Beta-alanine may help you buffer muscle fatigue! Find out more below...

By: Marie Spano

Article Summary:
  • Studies suggest that beta-alanine may affect intramuscular carnosine levels.
  • Beta-alanine has been tested in women.
  • Endurance athletes may want to include Beta-alanine in their supplement arsenal.

For decades, lactic acid was blamed for everything from muscle soreness to fatigue. If an athlete "hit the wall" during a marathon, barely making it to the finish line, lactic acid buildup was to blame.

However, this theory, still spread like gospel among uneducated weekend warriors, was put to rest years ago by Dr. George Brooks. It really isn't the lactate or lactic acid that causes the problem but instead the build up of hydrogen ions and subsequent drop in pH that occurs during intense exercise, leading to fatigue. This is where beta-alanine comes into play.

What Is Beta-Alanine?

Beta-alanine is the rate-limiting enzyme in the synthesis of carnosine. In other words, the amount of carnosine your body produces is directly dependent on the amount of beta-alanine available. Without sufficient beta-alanine, carnosine synthesis is limited. So why is carnosine important?

Carnosine, which is composed of histidine + beta-alanine, helps buffer the acidity produced by hydrogen ion accumulation. Delaying acid production helps delay muscular fatigue allowing you to train at a higher intensity while also improving recovery between high-intensity exercise sets or intervals.

Carnosine is naturally found in the brain, heart, kidney, stomach and skeletal muscle (type II, fast twitch muscle, the kind that is engaged in sprinting and other explosive movements).

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Beta-Alanine is a non-essential amino acid that is used by muscle cells to synthesize Carnosine. Carnosine is the dipeptide (Beta-Alanine plus Histidine) that functions as a buffer for the hydrogen...
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In theory it would make more sense to go straight for the good stuff and ingest carnosine without fooling with beta-alanine. However, when carnosine enters the digestive system, it's broken down then reformed.

Therefore, carnosine can't be taken up into the muscle intact. In addition, studies suggest that taking beta-alanine produces more carnosine in the muscle than if you tried to supplement with carnosine itself.

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By promoting high levels of intramuscular carnosine, ?-Alanine promotes high energy levels and supports maximum muscular endurance and improved performance.

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How The Bodybuilding Supplement Beta-Alanine Can Buffer Muscle Fatigue

1. Beta-Alanine May Increase Carnosine Levels In The Body.

When conducting a supplement study, it's critical to make sure that it is the supplement and not some co-founding variable (the food they are eating for instance).

However, studies suggest that beta-alanine supplementation may increase intramuscular carnosine levels. In one study, 28 days of beta-alanine supplementation at a dose of 4-6 grams per day resulted in an increase in intramuscular carnosine levels by approximately 60%.

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When we eat a food containing carnosine it gets hydrolysed (broken down) to its constituent amino acids by the enzyme carnosinase, which is highly active in blood. These amino acids are then taken up into the muscle where they are reassembled or resynthesized to carnosine by carnosine synthetase.

[ Carnosine Sorted By Top Sellers ]

2. Beta-Alanine Supplementation Works In Women.

Most supplement studies are conducted in men for a variety of reasons (no need to control for time in the menstrual cycle, men typically want to bulk up etc.) but beta-alanine is one supplement that has been tested in women.

In one study examining the effects of this supplement on neuromuscular fatigue in women, twenty-two females were randomly assigned to receive either beta-alanine or a placebo for 28 days.

Before and after the supplementation period, participants performed a stationary bike test to exhaustion. Dr. Jeff Stout and his lab at the University of Oklahoma suggested that beta-alanine may delay the onset of neuromuscular fatigue during sub-maximal cycling and may increase time to exhaustion in women.

Beta-Alanine May Delay The Onset Of Neuromuscular Fatigue During Sub-Maximal Cycling And May Increase Time To Exhaustion In Women
+ Click To Enlarge.
Beta-Alanine May Delay The Onset Of Neuromuscular Fatigue During
Sub-Maximal Cycling And May Increase Time To Exhaustion
In Women.

3. Beta-Alanine May Delay Fatigue In Endurance Athletes.

In one of the initial studies examining the ergogenic potential of beta-alanine, 13 males with an average age of twenty-five, were supplemented with 4-6 mg of beta-alanine or a placebo everyday for 10 weeks. An exhaustive cycling test at 110% maximum power was completed before supplementation, at 4 weeks and after 10 weeks.

After 4 weeks and 10 weeks respectively, the supplemented group was able to cycle for a longer period of time in comparison to the group taking a placebo.

Ater a Beta-Alanine Regimen, The Supplemented Group Was Able To Cycle For A Longer Period Of Time In Comparison To The Group Taking A Placebo
+ Click To Enlarge.
Ater a Beta-Alanine Regimen, The Supplemented Group Was Able
To Cycle For A Longer Period Of Time In Comparison To The
Group Taking A Placebo.

4. Beta-Alanine May Work Synergistically With Creatine.

A few studies have highlighted potential synergistic benefits from the combination of beta-alanine + creatine in comparison to consuming either one alone.

In one double blind, placebo controlled study the combination of 1.6 grams/day beta-alanine + 5.25 g/day creatine suggested significant improvement in five of the eight indices of cardio-respiratory endurance measured.

The creatine-only group and beta-alanine only group both showed improvements in just two of the eight indices measured. There were, however, no significant differences between the beta-alanine + creatine group and the creatine-only and beta-alanine only groups.

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Additional Tips To Buffer Muscle Fatigue

  • Try Creatine. After all, just gaining strength and power can help you train harder which will build endurance.
  • Train Hard. Hardcore training boosts your body's production of carnosine.
  • Rest. Though it's important to train hard when you are training, junk miles are just that - junk.
  • Don't put in extra time going through the motions in an effort to get stronger, boost performance or lose weight. You'll end up over trained, tired and your performance may suffer.
  • Eat Enough Protein. Athletes need 1.2 - 2.0 grams of protein per kilogram body weight to build and repair muscle tissue.

If you are looking to go that extra mile and fight fatigue, beta-alanine may help you push through that barrier. If you supplement, choose a time released formula or opt for 800 mg doses eight times per day for at least one month.

Beta-alanine may work to delay the muscular fatigue that results from exercise. Though intense training increases muscle levels of carnosine, supplementation, over time, may raise the levels even higher.

Athletes Need 1.2 - 2.0 Grams Of Protein Per Kilogram Body Weight To Build And Repair Muscle Tissue
+ Click To Enlarge.
Athletes Need 1.2 - 2.0 Grams Of Protein Per Kilogram Body Weight
To Build And Repair Muscle Tissue.

About the Author:

Marie Spano is one of the country's top sports nutritionists and a nutrition communications expert. She combines science with practical experience to help Olympic, professional and recreational athletes implement a nutrition game plan that will maximize their athletic performance. She is a regular contributor to Bodybuilding.com.

For more information see: www.mariespano.com


  1. Int J Sport Nutr Exerc Metab 2006;16(4):430-46.
  2. Amino Acids 2007;32(2): 225-33.
  3. Amino Acids 2007;33(3):505-10.
  4. Int J Sport Nutr Exerc Metab. 2006 Aug;16(4):430-46.
  5. Amino Acids. 2006 May;30(3):279-89. Epub 2006 Mar 24.
  6. Amino Acids. 2009 Dec 20. [Epub ahead of print]

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